当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > The effect of human placenta cytotrophoblast cells on the maturation and T cell stimulating ability of dendritic cells in vitro.

The effect of human placenta cytotrophoblast cells on the maturation and T cell stimulating ability of dendritic cells in vitro.

Abstract：

:The success of pregnancy depends upon regulatory mechanisms that allow the fetus to survive and develop to term in the uterus, despite maternal immune cells' awareness of paternal alloantigens. At least some of these specific mechanisms are mediated by the effect of fetal trophoblast cells. In the present study we examine the effect of human placental cytotrophoblast cells (CTCs) on the maturation of dendritic cells (DCs) in vitro. For that purpose, CTCs were isolated from samples of placentae at 5-11 weeks of gestation and co-cultured with peripheral blood monocytes under conditions inducing DC maturation. CTC were shown to alter the morphology, phenotype and functional properties of DCs. As a result, a significant portion of cells acquire fibroblast-like morphology and some of the cells retain the expression of CD14. DCs matured in the presence of CTCs do not differ from usual DCs in terms of CD80, CD83 and CD86 expression, as well as the ability to induce allogenic lymphocytes proliferation. However, CTCs reduce significantly the ability of DCs to stimulate interferon-γ production and the loss of CD62L by T cells. The results obtained indicate that DCs may be involved in pregnancy-associated changes of cytokine production and T cell migration.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Talayev VY,Matveichev AV,Lomunova MA,Talayeva MV,Tsaturov ME,Zaichenko IY,Babaykina ON

doi

10.1111/j.1365-2249.2010.04149.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

91-9

issue

1

eissn

0009-9104

issn

1365-2249

pii

CEI4149

journal_volume

162

pub_type

杂志文章

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