Eosinophilic gastroenteritis: ultrastructural evidence for a selective release of eosinophil major basic protein.

abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

journal_title：Clinical and experimental immunology

authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

更新日期：1995-12-01 00:00:00

abstract：:Exposure to intratracheal immunization and aerosolization with soluble antigen plus murmayl-dipeptide (MDP) induces the development of plaque-forming cells in the pulmonary draining lymph nodes of two of three inbred mouse strains. Splenectomy before immunization led to a heightened plaque-forming cell response in the...

journal_title：Clinical and experimental immunology

authors： Allen EM,Abramoff P,Fink JN,Calvanico NJ

更新日期：1987-08-01 00:00:00

abstract：:Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated c...

journal_title：Clinical and experimental immunology

authors： Rowe D,Isenberg DA,Beverley PC

更新日期：1983-11-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:In inflammatory bowel disease (IBD), inflammation is sustained by an exaggerated response of lymphocytes. This results from enhanced expression of anti-apoptotic B cell lymphoma (BCL-2) and BCL-XL associated with a diminished turnover. Azathioprine (AZA) directly targets BCL-2 family-mediated apoptosis. We investigate...

journal_title：Clinical and experimental immunology

authors： Weder B,Mozaffari M,Biedermann L,Mamie C,Moncsek A,Wang L,Clarke SH,Rogler G,McRae BL,Graff CL,Ruiz PA,Hausmann M

更新日期：2018-09-01 00:00:00

abstract：:In view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (TGF) beta 1 to down-regulate immune responses in vivo. Preliminary experiments suggested that, at the doses used, systemic injection of soluble TGF beta 1 could not affect bacterial-i...

journal_title：Clinical and experimental immunology

authors： Strassmann G,Bertolini DR,Eidelman O

更新日期：1991-12-01 00:00:00

abstract：:The expression of cytokine mRNA species was determined in liver biopsies from six normal subjects, 18 patients with PBC and 14 patients with hepatitis B e antigen (HBeAg)-positive CHB using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique. cDNA, obtained by reverse transcription using oligo d(T) pr...

journal_title：Clinical and experimental immunology

authors： Shindo M,Mullin GE,Braun-Elwert L,Bergasa NV,Jones EA,James SP

更新日期：1996-08-01 00:00:00

abstract：:The synthesis of some class 1 acute-phase proteins (APP), including C-reactive protein (CRP) and serum amyloid A (SAA) protein is completely blocked by the IL-1 receptor antagonist (IL-1Ra), whereas the production of fibrinogen, a class 2 APP, is increased by IL-1Ra in hepatoma cells, but this has never been tested in...

journal_title：Clinical and experimental immunology

authors： Gabay C,Genin B,Mentha G,Iynedjian PB,Roux-Lombard P,Guerne PA

更新日期：1995-05-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is characterized by defective cellular transport of the dibasic amino acids, secondary dysfunction of the urea cycle, aversion to dietary protein, failure to thrive, hepatosplenomegaly and osteoporosis. Because several patients have suffered from recurrent respiratory infections and...

journal_title：Clinical and experimental immunology

authors： Lukkarinen M,Parto K,Ruuskanen O,Vainio O,Käyhty H,Olander RM,Simell O

更新日期：1999-06-01 00:00:00

abstract：:Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizyg...

journal_title：Clinical and experimental immunology

authors： Fyfe A,Holme ER,McKay IC,Zoma A,Hunter J,Lucie NP,Whaley K

更新日期：1987-10-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by clonal B cell attack of the exocrine glands and dysregulated expression of B cell-activating factor (BAFF). Based upon the current data of increased rates of lymphoid malignancy, as non-Hodgkin's lymphoma (NHL) is associated with SS, we propose the dete...

journal_title：Clinical and experimental immunology

authors： Guzmán LM,Castillo D,Aguilera SO

更新日期：2010-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

journal_title：Clinical and experimental immunology

authors： Yao QY,Rickinson AB,Gaston JS,Epstein MA

更新日期：1986-05-01 00:00:00

abstract：:During blood-stage infection of mice with a lethal variant of Plasmodium yoelii, cells in both spleen and liver became activated to reach a peak at day 5. In mice protected by vaccination, activation was accelerated after infection. The most striking difference observed was in the 10-fold greater yield of infiltrating...

journal_title：Clinical and experimental immunology

authors： Taverne J,Rahman D,Dockrell HM,Alavi A,Leveton C,Playfair JH

更新日期：1987-12-01 00:00:00

abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

journal_title：Clinical and experimental immunology

authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

更新日期：1993-07-01 00:00:00

abstract：:The tryptic FAD-peptide carrying the flavin in 8alpha-(N3)histidyl linkage as natural hapten was isolated by HPLC from the bacterial enzyme 6-hydroxy-d-nicotine oxidase. The same flavin protein linkage is found in the mitochondrial succinate dehydrogenase flavoprotein subunit, the predominant flavoprotein with covalen...

journal_title：Clinical and experimental immunology

authors： Cicek G,Schiltz E,Staiger J,Neumann FJ,Melchers I,Brandsch R

更新日期：2003-05-01 00:00:00

abstract：:Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order to elucidate the role of PDE7 in human T cell function, the effects of two PDE inhibitors on PDE7A activity, cytokine ...

journal_title：Clinical and experimental immunology

authors： Nakata A,Ogawa K,Sasaki T,Koyama N,Wada K,Kotera J,Kikkawa H,Omori K,Kaminuma O

更新日期：2002-06-01 00:00:00

abstract：:Nephrosis is characterized by glomerular epithelial cell injury and a decrease in the glomerular basement membrane (GBM) proteoglycan content. Although CsA is a useful treatment for a group of patients with this disease, its mechanism of action is unclear. We have previously shown that in experimental nephrosis there ...

journal_title：Clinical and experimental immunology

authors： Bustos C,González-Cuadrado S,Ruiz-Ortega M,Gómez-Guerrero C,González E,Plaza JJ,Egido J

更新日期：1995-12-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:Monocyte and macrophage dysfunction may be important for both immunopathogenesis and clinical manifestations in subgroups of patients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different me...

journal_title：Clinical and experimental immunology

authors： Aukrust P,Müller F,Frøland SS

更新日期：1994-08-01 00:00:00

abstract：:Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR) and eight carbohydrate recognition domains (CRD) that bind glycosylated proteins....

journal_title：Clinical and experimental immunology

authors： Chazenbalk GD,Pichurin PN,Guo J,Rapoport B,McLachlan SM

更新日期：2005-02-01 00:00:00

abstract：:Antibodies recognizing infliximab (IFX) may develop in a proportion of treated patients, leading to loss of response or hypersensitivity reactions (HRs). T cell response to IFX has been poorly investigated. This paper was addressed to detect IFX-specific T cells in treated patients with inflammatory diseases developin...

journal_title：Clinical and experimental immunology

authors： Vultaggio A,Petroni G,Pratesi S,Nencini F,Cammelli D,Milla M,Prignano F,Annese V,Romagnani S,Maggi E,Matucci A,ABIRISK Consortium.

更新日期：2016-12-01 00:00:00

abstract：:We investigated the clearance kinetics and tissue distribution of different sized IgA in normal and macrophage-depleted rats. Rats were injected iv with liposomes containing dichloromethylene diphosphonate (DMDP). DMDP treatment resulted in complete depletion of liver macrophages 24-48 h after administration. Normal a...

journal_title：Clinical and experimental immunology

authors： Bogers WM,Stad RK,Janssen DJ,Prins FA,van Rooijen N,van Es LA,Daha MR

更新日期：1991-07-01 00:00:00

abstract：:We have reported previously that the LAD-4 monoclonal antibody (mAb) directed against a fibronectin receptor (FNR) on RL-male-1 T lymphoma cells in BALB/c mice partially inhibited their migration to the liver. In the present study, we examined the mechanism by which another anti-FNR mAb, LAD-1, exerts its antitumourig...

journal_title：Clinical and experimental immunology

authors： Ito M,Omoto S,Kato Y,Hayashi T,Mori N,Fujii YR

更新日期：2005-07-01 00:00:00

abstract：:In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

journal_title：Clinical and experimental immunology

authors： Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

更新日期：1991-11-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:Female Hartley guinea-pigs were immunized with N-phthaloylated ox insulin (96% NA1,NB1,NB29-triphthaloyl ox insulin) using H. pertussis as adjuvant. Haptenic antibody, which was found in antisera taken 20 days after secondary immunization, was assessed for cross-reaction with a series of N-acylated ox insulins. Cross-...

journal_title：Clinical and experimental immunology

authors： Hollins PJ,Nathan MM

更新日期：1978-03-01 00:00:00

abstract：:The anti-EBV T cell response was studied in a severe combined immunodeficiency patient (PS) who received two transplants of fetal liver cells. His peripheral blood mononuclear cells (PBMC) were incubated with EBV and cultured during 15 days. Eleven colonies were derived from the T lymphocytes causing the regression of...

journal_title：Clinical and experimental immunology

authors： Plotnicky H,Touraine JL

更新日期：1993-12-01 00:00:00

abstract：:We set out to examine the effect of gold treatment on the Th2-dependent antibodies IgG4 and IgE in relation to other IgG subclasses in patients with rheumatoid arthritis (RA). Eighty-five gold-treated RA patients and 82 RA controls were studied. Serum IgG subclass concentrations were measured by ELISA, IgE was measure...

journal_title：Clinical and experimental immunology

authors： Kiely PD,Helbert MR,Miles J,Oliveira DB

更新日期：2000-05-01 00:00:00