The use of C1q, conglutinin and low affinity rabbit IgM antibody to human Fc in a ligand coctail radioassay for detecting and characterizing immune complexes in pathological sera.

abstract：:Monocyte and macrophage dysfunction may be important for both immunopathogenesis and clinical manifestations in subgroups of patients with primary hypogammaglobulinaemia. In the present study we examined the ability to generate reactive oxygen species (ROS) in isolated monocytes from these patients by two different me...

journal_title：Clinical and experimental immunology

authors： Aukrust P,Müller F,Frøland SS

更新日期：1994-08-01 00:00:00

abstract：:The adenine nucleotide translocator protein (ANT) is the first well-characterized mitochondrial polypeptide to be identified as an antigen for antimitochondrial autoantibodies (AMA) in PBC sera. Because of the potential use for a highly purified antigen as a tool in studying the aetiology of PBC, we have undertaken an...

journal_title：Clinical and experimental immunology

authors： Mendel-Hartvig I,Frostell A,Nelson BD

更新日期：1986-11-01 00:00:00

abstract：:Cellular immune responses against the oncoantigen anaplastic lymphoma kinase (ALK) in patients with ALK-positive anaplastic large cell lymphoma (ALCL) have been detected using peptide-based approaches in individuals preselected for human leucocyte antigen (HLA)-A*02:01. In this study, we aimed to evaluate nucleophosmi...

journal_title：Clinical and experimental immunology

authors： K Singh V,Werner S,Hackstein H,Lennerz V,Reiter A,Wölfel T,Damm-Welk C,Woessmann W

更新日期：2016-10-01 00:00:00

abstract：:The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied ov...

journal_title：Clinical and experimental immunology

authors： Pocidalo MA,Gibert C,Verroust P,Geniteau M,Adam C,Madec Y,Gaudebout C,Morel-Maroger L

更新日期：1982-03-01 00:00:00

abstract：:Using an autoimmune hepatitis model of A/J mice which was prepared with immunization by syngeneic crude liver proteins, various influences of neonatal thymectomy were studied by observations of histological liver changes, autoantibody to liver-specific membrane lipoprotein (LSP), delayed-type hypersensitivity (DTH) to...

journal_title：Clinical and experimental immunology

authors： Watanabe Y,Kawakami H,Kawamoto H,Ikemoto Y,Masuda K,Takezaki E,Nakanishi T,Kajiyama G,Takeno H

更新日期：1987-01-01 00:00:00

abstract：:In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of te...

journal_title：Clinical and experimental immunology

authors： Demmert M,Faust K,Bohlmann MK,Tröger B,Göpel W,Herting E,Härtel C

更新日期：2012-02-01 00:00:00

abstract：:Two amyloidogenic Bence Jones proteins (Am37 VkappaIV and NIG1 VkappaI) and one non-amyloidogenic protein (NIG26 VkappaIII) were characterized. The protein Am37 had four deletions when compared with the translated germ-line gene sequence: two Ser residues following position 27 (27e, 27f) in CDR1 and two amino acids Pr...

journal_title：Clinical and experimental immunology

authors： Alim MA,Yamaki S,Hossain MS,Takeda K,Kozima M,Izumi T,Takashi I,Shinoda T

更新日期：1999-12-01 00:00:00

abstract：:Ten sera from 48 patients with systemic sclerosis were found to be capable of producing cytotoxicity of human umbilical venous and arterial endothelium when co-cultured with peripheral blood mononuclear cells. Fractionation of sera on Ultrogel and the preparation of monomeric IgG by ion exchange and affinity chromatog...

journal_title：Clinical and experimental immunology

authors： Holt CM,Lindsey N,Moult J,Malia RG,Greaves M,Hume A,Rowell NR,Hughes P

更新日期：1989-12-01 00:00:00

abstract：:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

journal_title：Clinical and experimental immunology

authors： Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

更新日期：2001-03-01 00:00:00

abstract：:Immunotherapy of murine autoimmune and allergic diseases by administration of peptides corresponding to the dominant T cell epitope is a reality. However, problems remain in applying this therapy to reduce antibody responses in humans. To overcome these difficulties, a preclinical system was developed to test the effe...

journal_title：Clinical and experimental immunology

authors： Jackson DJ,Elson CJ,Kumpel BM

更新日期：2004-08-01 00:00:00

abstract：:Secretion of IgM and IgG in vitro by B cells from patients with common variable immunodeficiency (CVI) has been used to classify the disease into three groups. On stimulation with anti-IgM and IL-2, group A patients' cells fail to secrete IgM or IgG, group B patients' cells secrete no IgG and significantly lower level...

journal_title：Clinical and experimental immunology

authors： Franz A,Bryant A,Webster AD,Farrant J

更新日期：1992-03-01 00:00:00

abstract：:Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

journal_title：Clinical and experimental immunology

authors： Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

更新日期：2002-03-01 00:00:00

abstract：:Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism in BALB/c mice. In contrast, mice of the same strain vaccinated with TSHR-DNA have low or absent TSHR antibodies and their T cells recognize restricted epitopes on t...

journal_title：Clinical and experimental immunology

authors： Pichurin PN,Chen CR,Nagayama Y,Pichurina O,Rapoport B,McLachlan SM

更新日期：2004-03-01 00:00:00

abstract：:In both murine and human experimental systems, acute, low dose exposure of skin to ultraviolet B light (UVB) impairs the induction of allergic contact dermatitis (ACD) by haptens such as dinitrochlorobenzene (DNCB) in a significant proportion of individuals. By light microscopy, epidermal Langerhans cells (LC) have be...

journal_title：Clinical and experimental immunology

authors： Mommaas AM,Mulder AA,Vermeer M,Boom BW,Tseng C,Taylor JR,Streilein JW

更新日期：1993-06-01 00:00:00

abstract：:A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Alvaro S,Triolo G,Giacomelli R

更新日期：2015-10-01 00:00:00

abstract：:A phenotypic analysis of bronchoalveolar lavage fluid (BALF) and peripheral blood (PB) cells in maedi visna virus (MVV)-infected sheep has been performed. The differential cell count in BALF from MVV-infected animals was characterized by a significant increase (P < 0.05) in lymphocytes and neutrophils. Lymphocyte phen...

journal_title：Clinical and experimental immunology

authors： Luján L,Begara I,Collie DD,Watt NJ

更新日期：1993-02-01 00:00:00

abstract：:Perturbation of epithelial structure is a prominent but poorly understood feature of the immunopathological response to bacterial antigens which characterizes the destructive lesion of periodontitis. Western analysis of sera from 22 patients with periodontitis detected multiple antigens in extracts of epithelial cells...

journal_title：Clinical and experimental immunology

authors： Ye P,Harty DW,Chapple CC,Nadkarni MA,Carlo AA,Hunter N

更新日期：2003-03-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen respo...

journal_title：Clinical and experimental immunology

authors： Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

更新日期：1984-04-01 00:00:00

abstract：:B cells in normal human Peyer's patches and in primary B cell lymphomas of the stomach have been characterized in terms of their cellular morphology and their reactivity with a panel of monoclonal antibodies. A population of B cells is present in normal and malignant gut-associated lymphoid tissue which is composed of...

journal_title：Clinical and experimental immunology

authors： Spencer J,Finn T,Pulford KA,Mason DY,Isaacson PG

更新日期：1985-12-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

journal_title：Clinical and experimental immunology

authors： Bortolotti F,Realdi G,Diodati G,Fattovich G

更新日期：1978-08-01 00:00:00

abstract：:Lewis rats were immunized with bee venom allergen in Freund's complete adjuvant (FCA) or with FCA only. Animals immunized with bee venom developed specific IgG antibodies but no specific IgE antibodies were detected. Lymphocytes from lymph nodes when cultured with antigen in vitro showed an increased stimulation index...

journal_title：Clinical and experimental immunology

authors： Schneider H,Urbanek R

更新日期：1984-08-01 00:00:00

abstract：:To define glucocorticoid (GC)-regulated genes contributing to the anti-inflammatory and immunosuppressive effects of GC, previous work from our laboratory revealed up-regulation of transcripts from endogenous type B mouse mammary tumour virus (Mtv) and type C murine leukaemia virus (Emv) loci by high dose GC treatment...

journal_title：Clinical and experimental immunology

authors： Fiegl M,Strasser-Wozak E,Geley S,Gsur A,Drach J,Kofler R

更新日期：1995-08-01 00:00:00

abstract：:Nerve growth factor (NGF) regulates B cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes. We have reported recently that the number of memory B cells is reduced during HIV-1 infection. In this study we evaluated whether alteration in the NGF supply was involved in memory B...

journal_title：Clinical and experimental immunology

authors： Titanji K,Nilsson A,Mörch C,Samuelsson A,Sönnerborg A,Grutzmeier S,Zazzi M,De Milito A

更新日期：2003-05-01 00:00:00

abstract：:The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) using formalin-fixe...

journal_title：Clinical and experimental immunology

authors： Zhou Y,Wei YR,Zhang Y,Du SS,Baughman RP,Li HP

更新日期：2015-09-01 00:00:00

abstract：:It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co...

journal_title：Clinical and experimental immunology

authors： Katoh N,Hirano S,Suehiro M,Ikenaga K,Yamashita T,Sugawara N,Yasuno H

更新日期：2000-08-01 00:00:00

abstract：:Histone can mediate the binding of both free DNA and DNA complexed to anti-DNA antibody to the glomerular capillary wall. We tested whether performed histone-DNA-anti-DNA immune complexes (IC) could bind to the glomerular capillary wall. The immune complex, generated with anti-DNA antibody derived from an SLE patient ...

journal_title：Clinical and experimental immunology

authors： Morioka T,Fujigaki Y,Batsford SR,Woitas R,Oite T,Shimizu F,Vogt A

更新日期：1996-04-01 00:00:00

abstract：:Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. Under both situations, the lipid profile is characterized by accumulation of triglyceride-rich lipoproteins (TGRLs). This lipid profile is recognized as a risk factor for...

journal_title：Clinical and experimental immunology

authors： Saja MF,Cook HT,Ruseva MM,Szajna M,Pickering MC,Woollard KJ,Botto M

更新日期：2018-06-01 00:00:00

abstract：:Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacte...

journal_title：Clinical and experimental immunology

authors： Whiteson K,Agrawal S,Agrawal A

更新日期：2017-06-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a role in the fibrotic process of systemic sclerosis (SSc). Because hypoxia is associated with fibrosis in several profibrogenic conditions, we investigated whether CTGF expression in SSc fibroblasts is regulated by hypoxia. Dermal fibroblasts from patients with SSc and hea...

journal_title：Clinical and experimental immunology

authors： Hong KH,Yoo SA,Kang SS,Choi JJ,Kim WU,Cho CS

更新日期：2006-11-01 00:00:00