Abstract:
:The 20-kD homologous restriction factor (HRF20), which is identical to CD59, is a membrane-associated protein which inhibits the reaction of C9 to form membrane attack complex (MAC) of homologous complements. In various human glomerular diseases deposition of complement components is frequently seen and MAC is reported to associate with immune deposits. Using a specific monoclonal antibody, 1F5, against HRF20, we attempted to study the localization of HRF20 in human glomerulonephritides and to compare the localization of HRF20 with those of immune deposits and MAC. The frozen sections of kidney specimens were fixed in acetone at room temperature before staining. In normal kidneys and kidney specimens from the patients with minimal change nephrotic syndrome, membranous nephropathy, and IgA nephropathy, HRF20 was strongly localized in the peritubular capillaries and along Bowman's capsules. A weaker but well-defined staining was obtained in the mesangial area and faint staining was seen along the glomerular capillary walls. In contrast, glomerular capillary walls were rather strongly stained in the cases with diffuse lupus nephritis which had subendothelial dense deposits. These data suggest that HRF20 (CD59) is present in the human glomeruli and its expression is enhanced under certain conditions such as lupus nephritis.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Tamai H,Matsuo S,Fukatsu A,Nishikawa K,Sakamoto N,Yoshioka K,Okada N,Okada Hdoi
10.1111/j.1365-2249.1991.tb08158.xsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
256-62issue
2eissn
0009-9104issn
1365-2249journal_volume
84pub_type
杂志文章abstract::Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...
journal_title:Clinical and experimental immunology
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abstract::The aim of the study was to test whether normal rat epiphyseal chondrocytes react with monoclonal antibodies (MoAbs) detecting different markers of lymphoid cells. For this purpose, isolated chondrocyte and, for comparison, splenocyte cytosmears were exposed to a battery of different MoAbs followed by indirect immunop...
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1982-05-01 00:00:00
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doi:
更新日期:1980-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2249.1997.tb08315.x
更新日期:1997-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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