Detection of a circulating form of vascular cell adhesion molecule-1: raised levels in rheumatoid arthritis and systemic lupus erythematosus.

abstract：:The recommended control option against onchocerciasis is repeated ivermectin treatment, which will need to be implemented for decades, and it remains unknown how repeated ivermectin therapy might affect immunity against Onchocerca volvulus in the long term. O. volvulus-specific antibody reactivity and cellular cytokin...

journal_title：Clinical and experimental immunology

authors： Mai CS,Hamm DM,Banla M,Agossou A,Schulz-Key H,Heuschkel C,Soboslay PT

更新日期：2007-03-01 00:00:00

abstract：:Blood monocytes of patients with thyroid autoimmune disease (TAID) display defects in rearranging their cortical actomyosin cytoskeleton ('polarize') in response to chemoattractants. Such rearrangements also take place after the adherence of monocytes to the extracellular matrix (ECM). It is therefore not surprising t...

journal_title：Clinical and experimental immunology

authors： Canning MO,Grotenhuis K,De Haan-Meulman M,De Wit HJ,Berghout A,Drexhage HA

更新日期：2001-07-01 00:00:00

abstract：:Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays ...

journal_title：Clinical and experimental immunology

authors： Mallone R,Mannering SI,Brooks-Worrell BM,Durinovic-Belló I,Cilio CM,Wong FS,Schloot NC,T-Cell Workshop Committee, Immunology of Diabetes Society.

更新日期：2011-01-01 00:00:00

abstract：:To identify and measure the spontaneous cell-mediated cytotoxicity of natural killer cells, we used the lysis of an established lymphoblastoid cell line as target in a 4-hr 51Cr-release assay. Mononuclear cell suspensions of the peripheral blood of thirty-four patients with Crohn's disease (group CD), eleven patients ...

journal_title：Clinical and experimental immunology

authors： Auer IO,Ziemer E,Sommer H

更新日期：1980-10-01 00:00:00

abstract：:To investigate the role of seminal plasma in human B cell functions, its effect on the proliferation and antibody secretion of tonsillar B cells and an Epstein-Barr virus (EBV) transformed human B cell line, A4, was examined. Seminal plasma inhibited both the proliferation and differentiation of normal B cells only wh...

journal_title：Clinical and experimental immunology

authors： Lee HK,Lee HH,Park YM,Lee JH,Ha TY

更新日期：1991-07-01 00:00:00

abstract：:A phenotypic analysis of bronchoalveolar lavage fluid (BALF) and peripheral blood (PB) cells in maedi visna virus (MVV)-infected sheep has been performed. The differential cell count in BALF from MVV-infected animals was characterized by a significant increase (P < 0.05) in lymphocytes and neutrophils. Lymphocyte phen...

journal_title：Clinical and experimental immunology

authors： Luján L,Begara I,Collie DD,Watt NJ

更新日期：1993-02-01 00:00:00

abstract：:Circulating immune complexes (CIC) have been postulated to contribute to the development of secondary complications in diabetes mellitus. In this study, CIC were measured in control rats and both insulin deficient and insulin treated streptozotocin-induced diabetic rats. CIC were more prevalent in both groups of diabe...

journal_title：Clinical and experimental immunology

authors： Abrass CK

更新日期：1984-07-01 00:00:00

abstract：:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individu...

journal_title：Clinical and experimental immunology

authors： Roberts PP,Dockrell HM,McAdam KP

更新日期：1988-06-01 00:00:00

abstract：:The effect of a standard laparatomy on antibody synthesis was studied in Wistar R/A rats recieving an intravenous injection of 10(9) sheep red blood cells (SRBC) during the surgical procedure. Anti-SRBC antibody titres were significantly higher in operated animals than in controls. When SRBC were given 2 hr after the ...

journal_title：Clinical and experimental immunology

authors： Kinnaert P,Mahieu A,Van Geertruyden N

更新日期：1978-05-01 00:00:00

abstract：:Supernatants of concanavalin A (Con A)-activated human spleen cells have been previously shown to inhibit polyclonal immunoglobulin (Ig) biosynthesis by pokeweed mitogen (PWM)-stimulated human spleen and peripheral blood mononuclear cells. In the present study, hydrocortisone was added at the beginning of in vitro cul...

journal_title：Clinical and experimental immunology

authors： Ilfeld D,Krakauer RS

更新日期：1982-04-01 00:00:00

abstract：:Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement, are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either...

journal_title：Clinical and experimental immunology

authors： Kerbel RS,Birbeck MS,Robertson D,Cartwright P

更新日期：1975-04-01 00:00:00

abstract：:The success of pregnancy depends upon regulatory mechanisms that allow the fetus to survive and develop to term in the uterus, despite maternal immune cells' awareness of paternal alloantigens. At least some of these specific mechanisms are mediated by the effect of fetal trophoblast cells. In the present study we exa...

journal_title：Clinical and experimental immunology

authors： Talayev VY,Matveichev AV,Lomunova MA,Talayeva MV,Tsaturov ME,Zaichenko IY,Babaykina ON

更新日期：2010-10-01 00:00:00

abstract：:The membrane attack complex (MAC) of complement is activated by immune and non-immune mechanisms in the kidney. MAC has been found associated with glomerular immune deposits, but also to cell remnants, particularly along tubules and in vessel walls. Clusterin and S-protein (vitronectin) bind to MAC, rendering it cytol...

journal_title：Clinical and experimental immunology

authors： French LE,Tschopp J,Schifferli JA

更新日期：1992-06-01 00:00:00

abstract：:The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect...

journal_title：Clinical and experimental immunology

authors： Tecklenborg J,Clayton D,Siebert S,Coley SM

更新日期：2018-05-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

journal_title：Clinical and experimental immunology

authors： Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

更新日期：1997-02-01 00:00:00

abstract：:Both the complement system and tissue factor (TF), a key initiating component of coagulation, are activated in sepsis, and cross-talk occurs between the complement and coagulation systems. C1-inhibitor (C1-INH) can act as a regulator in both systems. Our aim in this study was to examine this cross-talk by investigatin...

journal_title：Clinical and experimental immunology

authors： Landsem A,Nielsen EW,Fure H,Christiansen D,Ludviksen JK,Lambris JD,Østerud B,Mollnes TE,Brekke OL

更新日期：2013-08-01 00:00:00

abstract：:IgM-rheumatoid factor (RF) interference in the determination of total serum IgE and IgE-containing circulating immune complexes (IgE-CIC) was studied by inhibition experiments in vitro comparing a new ELISA technique free of IgM-RF interference with more widely used RIA methods. It was shown that a considerable overes...

journal_title：Clinical and experimental immunology

authors： De Clerck LS,Gigase PL,Bridts CH,Stevens WJ

更新日期：1988-04-01 00:00:00

abstract：:Kawasaki disease (KD) is a systemic vasculitis with cardiac and noncardiac complications. Anti--endothelial cell antibodies (AECA) are found among many patients with KD. The aim of this study was to investigate the pathogenic role of AECA in KD using in vitro and in vivo experimental models. F(ab)2 fragments of IgG-AE...

journal_title：Clinical and experimental immunology

authors： Grunebaum E,Blank M,Cohen S,Afek A,Kopolovic J,Meroni PL,Youinou P,Shoenfeld Y

更新日期：2002-11-01 00:00:00

abstract：:Antigen-antibody complexes, composed of 125I-BSA and guinea-pig or rabbit antibody, were incubated at 37 degrees C with human blood cells suspended in autologous serum and kinetics of binding analysed. When purified polymorphonuclear (PMN) or mononuclear cells (MNC) were studied, maximum binding was observed within 8 ...

journal_title：Clinical and experimental immunology

authors： Medof ME,Prince GM,Oger JJ

更新日期：1982-06-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is characterized by defective cellular transport of the dibasic amino acids, secondary dysfunction of the urea cycle, aversion to dietary protein, failure to thrive, hepatosplenomegaly and osteoporosis. Because several patients have suffered from recurrent respiratory infections and...

journal_title：Clinical and experimental immunology

authors： Lukkarinen M,Parto K,Ruuskanen O,Vainio O,Käyhty H,Olander RM,Simell O

更新日期：1999-06-01 00:00:00

abstract：:Anti-CD2 MoAbs have previously been shown to induce tolerance and to block B cell differentiation, T cell and monocyte activation. Since these immune functions are important in joint inflammation, we asked whether administration of the anti-CD2 MoAb OX34 has a beneficial effect on established rat adjuvant arthritis, a...

journal_title：Clinical and experimental immunology

authors： Hoffmann JC,Herklotz C,Zeidler H,Bayer B,Westermann J

更新日期：1997-10-01 00:00:00

abstract：:Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

journal_title：Clinical and experimental immunology

authors： Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

更新日期：1984-01-01 00:00:00

abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

journal_title：Clinical and experimental immunology

authors： Vervliet G,Carton H,Meulepas E,Billiau A

更新日期：1984-10-01 00:00:00

abstract：:Haemorrhage produces alterations in macrophage, T and B cell function. In order to better define the mechanism for the effects of blood loss on immune response, we examined function of and cytokine production by purified T cells, CD4+ and CD8+ subpopulations after blood loss. Whereas T and CD4+ cells from control, unh...

journal_title：Clinical and experimental immunology

authors： Abraham E,Chang YH

更新日期：1992-12-01 00:00:00

abstract：:We have examined the cell-mediated immunity (CMI) to Staphylococcus aureus (S. aureus) and Staphylococcal enterotoxin B (SEB) in peripheral blood mononuclear cells (PBMC) from children with atopic dermatitis (AD) and from non-atopic child controls by measurement of proliferative responses and production of the cytokin...

journal_title：Clinical and experimental immunology

authors： Campbell DE,Kemp AS

更新日期：1997-02-01 00:00:00

abstract：:The most likely source of autoantigens in systemic lupus erythematosus (SLE) is apoptotic material. Because increased levels of circulating apoptotic cells are found in SLE we wanted to investigate the capacity of serum from patients with SLE or other autoimmune or infectious diseases and normal healthy donors (NHD) t...

journal_title：Clinical and experimental immunology

authors： Bengtsson AA,Sturfelt G,Gullstrand B,Truedsson L

更新日期：2004-03-01 00:00:00

abstract：:Most patients with late-onset bypogammaglobulinaemia have normal numbers of B cells. In addition, some of these patients have been shown to have circulating T cells which suppress immunolobulin production in vitro. From our present studies on a large series of patients it appears that these two findings distinguish tw...

journal_title：Clinical and experimental immunology

authors： Platts-Mills TA,De Gast GC,Webster AD,Asherson GL,Wilkins SR

更新日期：1981-05-01 00:00:00

abstract：:Patients with Hodgkin's disease have increased numbers of spontaneously proliferating circulating lymphocytes. In order to test the relationship between this phenomenon and the in vitro mitogenic response, both spontaneous lymphocyte proliferation and the response to stimulation with phytohaemagglutinin were quantifie...

journal_title：Clinical and experimental immunology

authors： Shiftan TA,Caviles AP Jr,Mendelsohn J

更新日期：1978-04-01 00:00:00

abstract：:This report describes the presence of a T lymphocyte subpopulation in germinal centres of lymph follicles. This subpopulation is defined by reactivity with Leu 7 antibody, in addition to OKT11, OKT1, OKT3 and OKT4 positivity. The functional activity of this T lymphocyte subpopulation is a matter of discussion and has ...

journal_title：Clinical and experimental immunology

authors： Poppema S,Visser L,De Leij L

更新日期：1983-12-01 00:00:00