Abstract:
:CD5 is an antigen normally found on T cells and on a minority subpopulation of B cells in fetal spleen and tonsil and on the majority of cells in B-chronic lymphocytic leukaemia. Recent reports described the occurrence of large numbers of CD5-positive B cells in the peripheral blood after bone marrow transplantation (BMT). We examined the peripheral blood for CD5-positive B cells in 21 patients who underwent allogeneic BMT for leukaemia with marrow first depleted of T cells using anti-T monoclonal antibodies and complement mediated lysis. Twenty-six samples were obtained from patients 24-644 days after BMT and examined for the existence of blood-borne CD5-positive B cells by immunofluorescence analysis microscopically and by flow cytometry. The number of CD5-positive B cells was consistently lower than 2%. The absence of CD5-positive B cells in this series may be due to the method of T cell depletion of the marrow or to methodological differences in the analysis of the cells.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Drexler HG,Brenner MK,Wimperis JZ,Gignac SM,Janossy G,Prentice HG,Hoffbrand AVsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
662-8issue
3eissn
0009-9104issn
1365-2249journal_volume
68pub_type
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