Neurotrophins modulate monocyte chemotaxis without affecting macrophage function.


:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervous system. Increasing evidence suggests that they also have physiological and pathological roles outside the nervous system. In this study we examined the expression of neurotrophins and their receptors in human activated macrophages and to what extent neurotrophins themselves modulate macrophage activation, in a model of primary adult monocyte-derived macrophage. Our data indicate that macrophages express neurotrophin and neurotrophin receptor genes differentially, and respond to cell stimulation by specific inductions. Neurotrophins did not modify the antigen-presenting capacities of macrophages or their production of proinflammatory cytokines, but somehow skewed their activation phenotype. In contrast, NGF clearly increased CXCR-4 expression in macrophage and their chemotactic response to low CXCL-12 concentration. The differential effect of specific macrophage stimuli on neurotrophin expression, in particular NGF and NT-3, and the specific enhancement of CXCR-4 expression suggest that neurotrophins might participate in tissue-healing mechanisms that should be investigated further in vivo.


Clin Exp Immunol


Samah B,Porcheray F,Gras G




Has Abstract


2008-03-01 00:00:00














  • Modulation of M(2) muscarinic receptor-receptor interaction by immunoglobulin G antibodies from Chagas' disease patients.

    abstract::Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

    更新日期:2011-05-01 00:00:00

  • Up-regulation of ICAM-1, CD11a/CD18 and CD11c/CD18 on human THP-1 monocytes stimulated by Streptococcus suis serotype 2.

    abstract::Streptococcus suis serotype 2 is known to be a major pathogen of swine, causing mainly meningitis. It is also a zoonotic agent leading predominantly to meningitis in humans working in close contact with pigs. In this study, we investigated the ability of S. suis to up-regulate the expression of adhesion molecules invo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Al-Numani D,Segura M,Doré M,Gottschalk M

    更新日期:2003-07-01 00:00:00

  • Relationship of granulocyte colony stimulating factor with other acute phase reactants in man.

    abstract::The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimul...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Noursadeghi M,Pepys MB,Gallimore R,Cohen J

    更新日期:2005-04-01 00:00:00

  • Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.

    abstract::Kawasaki disease (KD) is the leading cause of acquired heart disease of children in North America. It is characterized by a massive immune activation and multi-system vasculitis, which evolves into a site-specific inflammatory response focused at the coronary arteries. Coronary artery (CA) inflammation leads to elasti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lau AC,Duong TT,Ito S,Wilson GJ,Yeung RS

    更新日期:2009-08-01 00:00:00

  • Microbial interactions in the atopic march.

    abstract::The human body is populated by a large number of microorganisms and exist in symbiosis with these immensely diverse communities, which are suggested to influence health and disease. The microbiota plays an essential role in the maturation and function of the immune system. The prevalence of atopic diseases has increas...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审


    authors: Nibbering B,Ubags NDJ

    更新日期:2020-01-01 00:00:00

  • Ethyl pyruvate significantly inhibits tumour necrosis factor-α, interleukin-1β and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury.

    abstract::In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Luan ZG,Zhang J,Yin XH,Ma XC,Guo RX

    更新日期:2013-06-01 00:00:00

  • A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study.

    abstract::Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the prevalence of autoantibodies to tissue transglutaminase (TGA), thyroid peroxidase (TPOA) and gastric H+...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Kozhakhmetova A,Wyatt RC,Caygill C,Williams C,Long AE,Chandler K,Aitken RJ,Wenzlau JM,Davidson HW,Gillespie KM,Williams AJK

    更新日期:2018-06-01 00:00:00

  • Production of interleukin (IL)-5 and IL-10 accompanies T helper cell type 1 (Th1) cytokine responses to a major thyroid self-antigen, thyroglobulin, in health and autoimmune thyroid disease.

    abstract::Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

    更新日期:2007-02-01 00:00:00

  • Endogenous glucocorticoids attenuate Shiga toxin-2-induced toxicity in a mouse model of haemolytic uraemic syndrome.

    abstract::The concept that during an immune challenge the release of glucocorticoids (GC) provides feedback inhibition on evolving immune responses has been drawn primarily from studies of autoimmune and/or inflammatory processes in animal models. The epidemic form of haemolytic uraemic syndrome (HUS) occurs secondary to infect...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Gómez SA,Fernández GC,Vanzulli S,Dran G,Rubel C,Berki T,Isturiz MA,Palermo MS

    更新日期:2003-02-01 00:00:00

  • Analysis of gamma delta V region usage in normal and diseased human intestinal biopsies and peripheral blood by polymerase chain reaction (PCR) and flow cytometry.

    abstract::The intestinal population of gamma delta T cell receptor (TCR)-bearing cells was characterized with regard to V delta and V gamma subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V delta 1 subtype was demonstrated in the smal...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Bucht A,Söderström K,Esin S,Grunewald J,Hagelberg S,Magnusson I,Wigzell H,Grönberg A,Kiessling R

    更新日期:1995-01-01 00:00:00

  • Epigenetic alterations on C1-inhibitor expression may influence hereditary angioedema attack frequency and C4 levels: Comment on: Karagianni P, Goules AV, Tzioufas AG. Epigenetic alterations in Sjogren's syndrome patient saliva.

    abstract::Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control ...

    journal_title:Clinical and experimental immunology

    pub_type: 评论,杂志文章


    authors: Khan S,Longhurst H

    更新日期:2020-11-01 00:00:00

  • Accessory cell activity of monocytes in anti-DNA antibody production in systemic lupus erythematosus.

    abstract::Depletion of monocytes from peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE) resulted in a decreased anti-DNA antibody synthesis in vitro. The addition of monocytes restored the response by lymphocytes and the maximum response in the presence of 2.5-8% of monocytes, whereas greate...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Sasaki T,Shibata S,Hirabayashi Y,Sekiguchi Y,Yoshinaga K

    更新日期:1989-07-01 00:00:00

  • Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers.

    abstract::Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Löfdahl JM,Wahlström J,Sköld CM

    更新日期:2006-09-01 00:00:00

  • Correlation between mixed lymphocyte culture and phytohaemagglutinin stimulation responses of human lymphocytes.

    abstract::In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Nanra SK,Boettcher B

    更新日期:1980-07-01 00:00:00

  • H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome.

    abstract::Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be different in tissues, depending...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Guggino G,Triolo G,Giacomelli R

    更新日期:2018-02-01 00:00:00

  • Anti-DNA antibody derived from a systemic lupus erythematosus (SLE) patient forms histone-DNA-anti-DNA complexes that bind to rat glomeruli in vivo.

    abstract::Histone can mediate the binding of both free DNA and DNA complexed to anti-DNA antibody to the glomerular capillary wall. We tested whether performed histone-DNA-anti-DNA immune complexes (IC) could bind to the glomerular capillary wall. The immune complex, generated with anti-DNA antibody derived from an SLE patient ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Morioka T,Fujigaki Y,Batsford SR,Woitas R,Oite T,Shimizu F,Vogt A

    更新日期:1996-04-01 00:00:00

  • Autoantibodies against the inner aspect of erythrocyte membranes in NZB mice.

    abstract::Erythrocyte autoantibodies in NZB mice react by hemagglutination methods with exposed and hidden red cell antigens. The hidden antigens can be exposed by treatment with proteolytic enzymes. By indirect immunofluorescence one antibody population can be shown to react with modified red cells. In the present study the lo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Linder E

    更新日期:1977-03-01 00:00:00

  • Interaction of endothelial cells and neutrophils in vitro: kinetics of thrombomodulin, intercellular adhesion molecule-1 (ICAM-1), E-selectin, and vascular cell adhesion molecule-1 (VCAM-1): implications for the relevance as serological disease activity m

    abstract::Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin, ICAM-1, VCAM-1 and E-selectin are of particular interest. However, only thrombomodulin showed the expected close correlation. ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Boehme MW,Raeth U,Scherbaum WA,Galle PR,Stremmel W

    更新日期:2000-01-01 00:00:00

  • Immunoglobulin (Ig)M antibodies against oxidized cardiolipin but not native cardiolipin are novel biomarkers in haemodialysis patients, associated negatively with mortality.

    abstract::The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patien...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Frostegård AG,Hua X,Su J,Carrero JJ,Heimbürger O,Bárány P,Stenvinkel P,Frostegård J

    更新日期:2013-12-01 00:00:00

  • Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.

    abstract::Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially those with specificity for proteinase 3 (PR-3) and myeloperoxidase, are valuable markers for differential diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG) and other vasculitides. Till now, several concep...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Mayet WJ,Schwarting A,Meyer zum Büschenfelde KH

    更新日期:1994-09-01 00:00:00

  • Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs.

    abstract::Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifur...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lelchuk R,Cardoni RL,Levis S

    更新日期:1977-12-01 00:00:00

  • Interactions of Mycobacterium lepraemurium with resident peritoneal macrophages; phagocytosis and stimulation of the oxidative burst.

    abstract::Live Mycobacterium lepraemurium or 60Co-gamma-irradiated organisms stimulated a very weak oxidative burst compared with similar numbers of heat-killed organisms or with live M. microti. This was found to reflect the poor uptake of the living organisms rather than an absolute failure to stimulate an oxidative burst. It...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Brett SJ,Butler R

    更新日期:1988-01-01 00:00:00

  • Plasma cytokine response to surgical stress in schizophrenic patients.

    abstract::Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Kudoh A,Sakai T,Ishihara H,Matsuki A

    更新日期:2001-07-01 00:00:00

  • Studies on HLA antigens and cellular and humoral autoimmune phenomena in patients with myasthenia gravis.

    abstract::The HLA phenotype of fifty-four patients with myasthenia gravis (MG) was compared to that of 600 controls. When male and female patients were compared separately with the control group, HLA-B12 was increased in MG males (P less than 0-023) and HLA-A1, B8 in MG females (P less than 0-023). In addition, HLA-A1, B8 was c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Gross WL,Krüger J,Gröschel-Stewart U,Friedrich H,Kunze K

    更新日期:1977-01-01 00:00:00

  • Electrophoresis of lymphoid cells. Differences in the cell membrane structure of murine thymocytes, T and B cells revealed by enzyme and formalin treatment.

    abstract::Low concentrations of protease and trypsin reduced the electrophoretic mobility (EPM) of thymocytes; with higher concentrations it was normal or above. Differences in membrane structure of thymocytes, T and B cells was found as B cells showed no reduction while T cells gave intermediate values. Further the reduction w...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Wiig JN

    更新日期:1975-10-01 00:00:00

  • Serum and salivary responses to oral tetravalent reassortant rotavirus vaccine in newborns.

    abstract::Serum and salivary responses of 95 infants to either a standard (4 x 10(4) plaque-forming units (PFU), 47 neonates) or a high dose (4 x 10(5) PFU, 48 neonates) of tetravalent reassortant rhesus rotavirus vaccine (administered at 2 days and at 6 weeks of age) were evaluated in a double-blind clinical trial. Serum and s...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章


    authors: Friedman MG,Segal B,Zedaka R,Sarov B,Margalith M,Bishop R,Dagan R

    更新日期:1993-05-01 00:00:00

  • Purification of normal human eosinophils using the different binding capacities of blood leucocytes for complexed rabbit IgG.

    abstract::A method has been developed for separating eosinophils from other types of leucocyte in normal individuals. Erythrocytes are sedimented with dextran, and mononuclear cells are removed on an isotonic density gradient of ficoll and sodium diatrizoate. The eosinophils and neutrophils are then washed and sedimented onto p...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Tai PC,Spry CJ

    更新日期:1977-05-01 00:00:00

  • Busulfan and chloramphenicol induced T cell lymphoma: cell surface characteristics and functional properties.

    abstract::We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol. The lymphoma cells displayed Thy-1.2, brain associated antigen, and H-2d alloantigen. They were negative for surface IgM and Ia antigens. Expression of T cell differ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Bhoopalam N,Price K,Norgello H,Barone-Varelas J,Fried W

    更新日期:1986-06-01 00:00:00

  • Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia.

    abstract::Vitamin D has been shown to modulate innate immune responses in vitro and ex vivo; however, human in-vivo data are lacking. At high latitudes, seasonal vitamin D deficiency is common due to alternating ultraviolet (UV)-B radiation exposure. In the present study, we investigated whether levels of 25 hydroxyvitamin D(3)...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Kox M,van den Berg MJ,van der Hoeven JG,Wielders JP,van der Ven AJ,Pickkers P

    更新日期:2013-02-01 00:00:00

  • Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS.

    abstract::Reconstitution of Semliki forest virus infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG, and development of normally absent brain pathology. The brain pathological changes, including demyelinat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Fazakerley JK,Amor S,Webb HE

    更新日期:1983-04-01 00:00:00