Subsets of T lymphocytes in relation to T lymphocyte function in multiple sclerosis.

Abstract:

:T lymphocyte control of Epstein-Barr virus (EBV) infection of autologous B lymphocytes was examined in parallel to the enumeration of subpopulations of mononuclear cells in 22 multiple sclerosis (MS) patients and in 22 healthy individuals. All were seropositive for EBV. The incidence of lack of T cell control was significantly higher in patients than in controls, confirming previous published work. In the present study, we have shown in addition a significantly reduced proportion of OKT8+ cells and a significantly increased ratio of OKT4/OKT8 cells in the group of patients with lack of control. The findings point to abnormal immunoregulation in MS.

journal_name

Clin Exp Immunol

authors

Craig JC,Hawkins SA,Swallow MW,Lyttle JA,Patterson VH,Merrett JD,Haire M

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

548-55

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

61

pub_type

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