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Hypovitaminosis D and incidence of obesity: a prospective study.

Abstract：

:The aim of this study was to assess the relationship between obesity and vitamin D status cross-sectionally, the relationship between obesity and the incidence of hypovitaminosis D prospectively and inversely the relationship between vitamin D status and incidence of obesity in a population-based cohort study in Spain. At baseline (1996-1998), 1226 subjects were evaluated and follow-up assessments were performed in 2002-2004 and 2005-2007, participants undergoing an interview and clinical examination with an oral glucose tolerance test. At the second visit, 25-hydroxyvitamin D and intact parathyroid hormone concentrations were also measured. Prevalence of obesity at the three visits was 28.1, 36.2 and 39.5%, respectively. The prevalence of vitamin D deficiency (25-hydroxyvitamin D ≤ 20 ng/ml (≤ 50 nmol/l)) was 34.7%. Neither obesity at baseline (OR=0.98, 95% CI: 0.69-1.40, P=0.93) nor the development of obesity between baseline and the second evaluation (OR=0.80, 95% CI: 0.48-1.33, P=0.39) were significantly associated with vitamin D status. In subjects who were non-obese (BMI <30 kg/m²) at the second evaluation, 25-hydroxyvitamin D values ≤ 17 ng/ml (≤ 42.5 nmol/l) were significantly associated with an increased risk of developing obesity in the next 4 years (OR=2.35, 95% CI: 1.03-5.4, P=0.040 after diverse adjustments). We conclude that vitamin D deficiency is associated with an increased risk of developing obesity.

journal_name

Eur J Clin Nutr

journal_title

European journal of clinical nutrition

authors

González-Molero I,Rojo-Martínez G,Morcillo S,Gutierrez C,Rubio E,Pérez-Valero V,Esteva I,Ruiz de Adana MS,Almaraz MC,Colomo N,Olveira G,Soriguer F

doi

10.1038/ejcn.2013.48

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

680-2

issue

6

eissn

0954-3007

issn

1476-5640

pii

ejcn201348

journal_volume

67

pub_type

杂志文章

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