Abstract:
OBJECTIVE:To explore the potential contribution of respiratory infections and vitamin A intakes to the seasonal effect of vitamin A supplementation on child growth. METHODS:Data from a randomized double-blind placebo-controlled trial, in which a single high dose of vitamin A or placebo was given every 4 months to 1405 children aged 6-48 months were used for the analysis. In total, 4430 child-treatment cycles were examined, and for each cycle the children had their dietary intake, weight, and height assessed at the start and end. Linear regression models of the difference in height and weight during each treatment cycle were used and the within-child correlation was adjusted using the generalized estimating equations (GEE). Other covariables in the model included age, sex, percentage of days with acute lower respiratory infection and diarrhea, and cumulative doses of vitamin A. RESULTS:This study showed that a significant effect of vitamin A supplementation on linear growth was observed in all seasons in children with a low burden of respiratory infections, that is, < 21.5% of days with respiratory illness. In each season, the highest effect was found in children with a low burden of respiratory infections and low vitamin A intakes, that is, intakes < 400 RE/day. Children with a high burden of respiratory infections or high vitamin A intakes benefited less from vitamin A supplementation for their linear growth than children with a low burden of respiratory infections and low vitamin A intakes. Finally, there was no benefit for linear growth from vitamin A supplementation in children with both a high burden of respiratory infections and high vitamin A intakes regardless of the season. CONCLUSIONS:The effect of vitamin A supplementation on growth is dependent on season. Respiratory infections and vitamin A intakes are important factors underlying the seasonal effect of vitamin A supplementation on growth.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Hadi H,Dibley MJ,West KP Jrdoi
10.1038/sj.ejcn.1601920subject
Has Abstractpub_date
2004-07-01 00:00:00pages
990-9issue
7eissn
0954-3007issn
1476-5640pii
1601920journal_volume
58pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:BACKGROUND/OBJECTIVES:Exclusive enteral nutrition (EEN) is a safe and effective treatment modality for inducing remission in paediatric Crohn's disease (CD). The primary aim of this study was to compare the outcomes of EEN to corticosteroid (CS) therapy in newly diagnosed, treatment-naïve patients with CD. A secondary ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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abstract:OBJECTIVE:We set up a baseline data on urinary iodine excretion from a nationwide representative sample of rural schoolchildren before instituting iodine supplementation. DESIGN:Stratified multistage cluster sampling in three different strata: lowlands, foothills and mountainous areas. Early morning urine samples were...
journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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abstract::Effects of dietary intervention on dietary habits and nutrient levels were studied in 240 women aged 50-65 years who had been operated for a stage I-II breast cancer. Following surgery the women who had participated in a dietary history interview were randomly assigned to one of two groups. The intervention group (n =...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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abstract::Ingested protein is made available to the body following digestion and absorption as amino acids and contributes to the body's demand for amino acids for protein synthesis and other metabolic pathways. As the pattern of amino acids required for metabolism is substantially different from that ingested, extensive metabo...
journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601989
更新日期:2004-12-01 00:00:00
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