Abstract:
OBJECTIVE:To define the cellular basis for immune enhancement by a probiotic lactic acid bacteria strain (Bifidobacterium lactis HN019); and to determine whether immune enhancement can be optimized by delivery in oligosaccharide-enriched low-fat milk. DESIGN:A double-blind, three-stage before-and-after intervention trial. SETTING:Taipei Medical College Hospital, Taipei, Taiwan. SUBJECTS:Fifty healthy Taiwanese citizens (age range 41-81; median 60) randomly allocated to two groups. INTERVENTIONS:In stage 1 (run-in control stage) all subjects consumed reconstituted low-fat milk (LFM) for 3 weeks; in stage 2 (probiotic intervention) subjects consumed B. lactis in LFM (group A) or B. lactis in lactose-hydrolysed LFM (group B) for 3 weeks; in stage 3 all subjects returned to non-supplemented LFM for a further 3 weeks (washout stage). The innate immune functions of two different leucocyte types (polymorphonuclear (PMN) cells and natural killer (NK) cells) were assessed at four time points via in vitro analyses on peripheral blood samples. RESULTS:While consumption of LFM alone had no significant effect on immune responses, stage 2 results indicated significantly enhanced PMN cell phagocytosis and NK cell tumour killing activity following consumption of milk containing B. lactis. These increases levelled off following cessation of B. lactis consumption, but remained above the pre-treatment values. Increases in PMN and NK cell activity were greatest among subjects who consumed B. lactis in lactose-hydrolysed LFM. CONCLUSIONS:Dietary consumption of the probiotic bacterium B. lactis HN019 enhanced immune function of two different types of leucocytes; the degree of enhancement was increased by consuming B. lactis in an oligosaccharide-rich substrate. SPONSORSHIP:Financial support was provided by the New Zealand Dairy Board.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Chiang BL,Sheih YH,Wang LH,Liao CK,Gill HSdoi
10.1038/sj.ejcn.1601093subject
Has Abstractpub_date
2000-11-01 00:00:00pages
849-55issue
11eissn
0954-3007issn
1476-5640journal_volume
54pub_type
临床试验,杂志文章,随机对照试验abstract::This paper evaluates the safety for humans with regard to consumption of protein hydrolysates and fractions thereof, including bioactive peptides. The available literature on the safety of protein, protein hydrolysates, fractions thereof and free amino acids on relevant food legislation is reviewed and evaluated. A ne...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2009.56
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective study on the prevalence of these disorders in a large cohort of 318 female patients with AN...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.115
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Body composition assessment by computed tomography (CT) is increasingly used for diagnostic and prognostic purposes in various patient groups. This study aimed to compare the reliability and validity of a newly in-house developed segmentation software VikingSlice against a commercial software (Sli...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0110-5
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Early insulin secretion following a meal is representative for normal physiology and may depend on meal composition. To compare the effects of a fat-rich and a carbohydrate-rich mixed meal on insulinogenic index as a measure of early insulin secretion in normoglycemic women (NGM) and in women with ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602953
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The risk factors for metabolic syndrome may differ between Western and Asian countries due to their distinct dietary cultures. However, few studies have directly compared macronutrient intake and its association with the risk of metabolic syndrome in the US and Korean adults using national survey ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-017-0031-8
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between weight gain, changes in body composition and physiological characteristics of fitness during the recovery from anorexia nervosa. DESIGN:Longitudinal over eight weeks of intensive inpatient re-feeding (Wk 0-8). SETTING:The London Hospital Medical College. SUBJECTS:Ten fem...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:In the UK, colorectal cancer is the fourth most common cancer and the second most common cause of cancer death. Surgery is the primary modality of treatment, but it is not without complications. Post-operative complications have been linked to preoperative of weight loss and loss of lean tissue, and also t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-019-0414-0
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600994
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:To examine the effects of physical activity (PA) in adults with or without prehypertension at baseline on systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension risk by gender. METHODS:A total of 5986 men and 6525 women (≥18 years old) without hypertension-related disease at baselin...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0653-0
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND/OBJECTIVES:Healthy eating advice is informed, in part, by dietary surveys that rely on self-reported data. Misreporting of food intake may distort relationships between diet and health outcomes. This study directly quantified the food groups that were under-reported or over-reported in common dietary assessm...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0199-6
更新日期:2018-07-01 00:00:00
abstract::Although calcium supplements are widely used in the treatment of osteoporosis their beneficial effect is not conclusively established. The biochemical effects of a calcium supplement (1 g/d) given for between 6 and 36 months were studied in 20 postmenopausal osteoporotic women who had normal calcium absorption. The me...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To describe the nutritional status of schoolchildren from a rural area of Tanzania, with a particular emphasis on older adolescents to determine the timing of the growth spurt and differences by sex. DESIGN:A cross-sectional survey using a randomly selected sample. SUBJECTS:Six thousand eight hundred and on...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600890
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet quality indices are increasingly used in nutrition epidemiology as dietary exposures in relation to health outcomes. However, literature on the long-term stability of these indices is limited. We aimed to assess the stability of the validated Framingham Nutritional Risk Score (FNRS) and its c...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.167
更新日期:2012-03-01 00:00:00
abstract::The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous studies have analysed impacts on average intakes. Agueably however intakes that are of real concern are those which are some distance away from the recommendations. Fiscal measures might have a limited impact on such diets, and as a result, on health. We measure the impact of a fiscal int...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.281
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. DESIGN:In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Dat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601909
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:To compare if postprandial glucose and insulin responses to wholekernel rye bread are lower than to wheat bread, and to see if these responses to two types of rye breads are different. To explore starch digestion in more detail, rate of starch hydrolysis of same breads was measured in vitro. DESIGN:Subjects ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600716
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Children born to human immunodeficiency virus (HIV)-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. The objective of this study was to identify maternal, socioeconomic and child...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2012.136
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:Recent studies have demonstrated beneficial metabolic effects of dietary monounsaturated fatty acids (MUFA) in Type-2 diabetes mellitus (Type-2 DM). The question arises if dietary MUFA also has desirable effects on risk markers in subjects with high risk of developing Type-2 DM. SETTING:University department...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600855
更新日期:1999-10-01 00:00:00
abstract::The growth literature from developing countries is reviewed to assess the extent to which stunting, a phenomenon of early childhood, can be reversed in later childhood and adolescence. The potential for catch-up growth increases as maturation is delayed and the growth period is prolonged. However, maturational delays ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1994-02-01 00:00:00
abstract::Food fortification can deliver essential micronutrients to large population segments without modifications in consumption pattern, suggesting that fortified foods may be formulated for populations at risk for fragility fractures. This scoping review determined the extent to which randomized controlled studies have bee...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2016.42
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To investigate the relation between maternal smoking habits, plasma lipids and milk fatty acid (FA) content and composition. DESIGN:Breastfeeding mothers who gave birth to healthy, full-term infants were recruited. Mothers were interviewed on smoking habits, being defined smokers (S) when usually smoking at ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601711
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Fiber-rich diets have been proposed to lower circulating levels of inflammatory makers. Our objective was to investigate cross-sectional relationships between fiber intake and plasma fibrinogen. SUBJECTS/METHODS:We examined the relationship between plasma fibrinogen and dietary fiber in 20,960 me...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.194
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Children in China with Autism Spectrum Disorders (ASD) are prone to vitamin A deficiency (VAD). The present study compared two vitamin A supplements (VAS) in two groups of children with ASD and VAD to explore a better VAS program for children with ASD. METHOD:A total of 138 3-8-year-old children with ASD (1...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-00827-9
更新日期:2020-12-16 00:00:00
abstract:OBJECTIVE:To evaluate the possibility that measurement of the magnitude and distribution of fundamental somatic heat-producing units using dual-energy X-ray absorptiometry (DXA) can be used to estimate resting energy expenditure (REE) in both young and elderly women with different aerobic fitness levels. SUBJECTS AND ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602980
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To determine the resting metabolic rate in a sample of the Italian population, and to evaluate the validity of predictive equations for resting metabolic rate (RMR) from the literature in normal and obese subjects. DESIGN:Cross-sectional observational study. SETTINGS:Department of Human Physiology and Nutr...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601149
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:This study examined the prevalence of obesity and hypertension and associated behavioral risk factors in adult men and women in Uzbekistan. The study also examined the association between obesity and hypertension. METHOD:The analysis used data from the 2002 Uzbekistan Health Examination Survey, which include...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602465
更新日期:2006-12-01 00:00:00
abstract::Nuclear receptors for retinoids were discovered in 1987 and appeared to belong to the superfamily of steroid/thyroid hormone receptors characterized by a common structure in which the different functions (trans-activation, DNA binding and ligand binding) are present in discrete modular domains in the protein. Retinoid...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Undernutrition status at hospital admission is related to increased hospital costs. Handgrip strength (HGS) is an indicator of undernutrition, but the ability of HGS to predict hospitalization costs has yet to be studied. OBJECTIVE:To explore whether HGS measurement at hospital admission can predict patient...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.242
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:To investigate the effect of soy protein containing isoflavones on homocysteine (Hcy), C-reactive protein (CRP), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). SUBJECT/METHODS:In a randomized crossover desig...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602885
更新日期:2008-12-01 00:00:00