Abstract：
BACKGROUND/OBJECTIVES:Exclusive enteral nutrition (EEN) is a safe and effective treatment modality for inducing remission in paediatric Crohn's disease (CD). The primary aim of this study was to compare the outcomes of EEN to corticosteroid (CS) therapy in newly diagnosed, treatment-naïve patients with CD. A secondary aim was to describe the outcomes of EEN in a national cohort of paediatric CD patients over a 10-year period. SUBJECTS/METHODS:A retrospective chart review was conducted at the Irish national referral centre for paediatric CD. A case-matched analysis was conducted on two cohorts matched for age, gender, disease location, disease behaviour and disease activity, who received CS or EEN as their initial treatment. Subsequently, cohort analysis was conducted on all patients who undertook a course of EEN therapy between 2004 and 2013. RESULTS:The case-matched analysis found higher remission rates after treatment with EEN (24/28, 86%) compared with those with CS (15/28, 54%; P=0.02). Dietetic contacts were found to be pivotal to the success of treatment and the attainment of remission. In total, 59 patients completed EEN at some time-point in their disease course and were included in the cohort analysis. Sixty-nine per cent of this cohort entered clinical remission (41/59). EEN was found to be most effective when used as an initial treatment (P=0.004) and less effective in patients aged under 10 years (P=0.04). CONCLUSIONS:EEN should be strongly considered as a favourable primary treatment over CS, especially in those diagnosed over the age of 10 years.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Lafferty L,Tuohy M,Carey A,Sugrue S,Hurley M,Hussey Sdoi
10.1038/ejcn.2016.210subject
Has Abstractpub_date
2017-02-01 00:00:00pages
185-191issue
2eissn
0954-3007issn
1476-5640pii
ejcn2016210journal_volume
71pub_type
杂志文章abstract：:The refeeding syndrome is a potentially fatal condition that affects multiple organ systems. It is the consequence of fluid and electrolyte shifts that may occur in a malnourished patient following the introduction of nutrition therapy. The most prominent characteristic is hypophosphataemia. Although hyperammonaemia i...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
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更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:The hypothesis was tested that the rate of postmenopausal bone loss is inversely associated with long-term urinary excretion of phyto-oestrogens, as a marker of habitual dietary intake. DESIGN:Secondary analysis of a 10-year follow-up study (1979 1989) among postmenopausal women in the Netherlands. SUBJECTS...
journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1600659
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：10.1038/ejcn.2011.108
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:Dietary counseling and intervention based on application of conventional criteria have been ineffective in preventing the progressive weight loss associated with HIV infection. The aim of the study was to compare the progression of clinical and nutritional indicators during nutritional supplementation with or...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601276
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:In Hebei province, China, over six million people are potentially exposed to excessive iodine through consumption of high iodine underground drinking water and consumption of iodized salt. The aim of this study is to evaluate the contributions of drinking water and iodized salt on children's iodin...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.127
更新日期：2013-09-01 00:00:00
abstract：:Energy density of foods, as opposed to their sugar or fat content, is said to be a key determinant of energy intakes. Recent laboratory studies have shown that, under ad lib conditions, subjects consume a constant weight or volume of food, so that their energy intakes depend on the energy density of the diet. Because ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600879
更新日期：1999-10-01 00:00:00
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1038/ejcn.2017.55
更新日期：2017-09-01 00:00:00
abstract：OBJECTIVES:Swedish Obese Subjects (SOS) is a multidisciplinary project involving aspects of obesity ranging from description of the severely obese state to effects of surgical intervention on long-term mortality and morbidity. Dietary studies, which represent an integral part of SOS research activities, are the focus o...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600567
更新日期：1998-05-01 00:00:00
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.75
更新日期：2014-07-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2014.189
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To assess the effects of supplementation with the carotenoids, beta-carotene or lycopene, at levels achievable within a diet rich in fruit and vegetables, on immune function in a group of free-living healthy elderly. DESIGN:A double-blind randomized placebo-controlled trial. T cell subsets and the expression...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601187
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:To assess the relationship between maternal stress and distress in pregnancy and 5-8 years postpartum and child nutritional status. SUBJECTS/METHODS:Longitudinal cohort study carried out in Jundiai city, Southeast Brazil, involving 409 women followed throughout pregnancy to 5-8 years postpartum, a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.28
更新日期：2013-04-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601686
更新日期：2003-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:Famine exposure is a potential risk factor for adverse cardiometabolic health. However, the relationship between famine exposure during early life and carotid plaque in adulthood remains unclear. Therefore, the aim was to investigate the relationship between famine exposure during early life and the risks fo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00756-7
更新日期：2020-09-16 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.61
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To determine the origin of the poor digestibility of banana starch granules in the human small intestine. DESIGN:The subjects received the same experimental meal. SETTING:Nutrition Research Unit, Laënnec Hospital, CHU, Nantes. SUBJECTS:Six healthy young subjects. INTERVENTIONS:The digestion of raw green b...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2000-09-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2013-01-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-06-01 00:00:00
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doi：10.1038/sj.ejcn.1601112
更新日期：2001-01-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-03-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
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更新日期：1999-05-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2020-03-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601803
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In international surveys of food consumption and nutrient intake, it is essential that the dietary data are comparable when different databases and calculation programs are used. The aim of the present analysis was to examine the comparability of nutrient intake data calculated on the basis of ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601639
更新日期：2003-09-01 00:00:00
