Abstract：
OBJECTIVE:To determine dose-dependent relationship between ingested fat and its oxidation in the immediate post-prandial period in humans. DESIGN:Subjects were randomly selected for the study at the Dunn Clinical Nutrition Centre, Cambridge, UK. Subjects ingested naturally enriched 13C corn-oil doses (range 20-140g) in a whole-body indirect calorimeter, and were studied for 8 h. Ingested fat oxidation was estimated from the subject's breath 13C enrichment and total carbon dioxide production. Total fat and carbohydrate oxidation were estimated from non-protein oxygen and carbon dioxide exchanges. Endogenous fat oxidation was estimated as the difference between total fat and ingested fat oxidation. RESULTS:The amount of fat dose oxidized was nonlinearly related to the amount ingested. On average, 25.6+/-2.7% of the mean fat dose was oxidized. A significant (r = - 0.72, P < 0.001) inverse correlation was found between the amount of fat dose and the proportion oxidized. Endogenous carbohydrate oxidation was negatively and significantly correlated to fat dose oxidized (r= -0.61, P < 0.01), but it was not correlated to endogenous fat oxidation. CONCLUSIONS:There was a nonlinear relationship between amount of fat dose and its quantity that was oxidized in the immediate post-prandial period. The inverse relationship between the size of the fat load and the proportion that was oxidized post-prandially implies increased dietary fat storage beyond about 50 g in a normal resting adult. This has important implications for 13CO2-based studies.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Sonko BJ,Prentice AM,Coward WA,Murgatroyd PR,Goldberg GRdoi
10.1038/sj.ejcn.1601112subject
Has Abstractpub_date
2001-01-01 00:00:00pages
10-8issue
1eissn
0954-3007issn
1476-5640journal_volume
55pub_type
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