Abstract:
OBJECTIVE:To collect (i) baseline data and (ii) execute a large multicentre study examining the effect of trans alpha-linolenic acid on its incorporation into plasma lipids and on risk factors for coronary heart disease. DESIGN:Male volunteers were recruited and the habitual diet assessed by a 4-d weighed record. Fatty acid composition of plasma and platelet lipids were determined by gas chromatography at baseline. After a 6 week run-in period on a trans 'free' diet, male volunteers were randomised to consume 0.6 % of energy trans alpha-linolenic acid or to continue with a diet 'low' in trans alpha-linolenic acid for 6 weeks. SETTING:Three European university research departments supported by the research and development departments of the food industry. SUBJECTS:Male volunteers (88) recruited by local advertisement. METHODS:Replacement of 30 % of the fat of the habitual diet by margarine, oil and foods. Rapeseed oil was deodorised especially to produce the trans 'free' and 'high' trans foods for this study. The incorporation and conversion of trans alpha-linolenic acid into plasma lipids and platelets was assessed by gas chromatography and dietary compliance was verified by 4-d weighed record. RESULTS:Less trans alpha-linolenic acid isomers are incorporated into human plasma lipids in French volunteers than in Dutch or Scottish volunteers consuming their habitual diets. Trans 'free' alpha-linolenic acid-rich oil can be produced by careful deodorization during refining. The 'high' trans diet provided 1410+/-42 mg/d trans isomers of alpha-linolenic acid, whilst the 'low' trans group consumed 60+/-75 mg/d. The change in plasma lipid and platelet fatty acid composition documented that trans linolenic isomers are incorporated and converted to a trans isomer of eicosapentaenoic acid. Only the 15-trans alpha-linolenic acid is incorporated into plasma cholesteryl esters. The group consuming low trans diet had a slightly higher intake of fat, especially saturated and monounsaturated fat. CONCLUSIONS:Trans 'free' rapeseed oil, rich in alpha-linolenic acid, can be produced by careful deodorization. Dietary records show good compliance. Dietary trans isomers of alpha-linolenic acid are incorporated in plasma lipids and converted to long-chain polyunsaturated fatty acids. Their effects on risk factors for coronary heart disease and their metabolism will be reported elsewhere. SPONSORSHIP:European Commission (FAIR 95-0594 grant). European Journal of Clinical Nutrition (2000) 54, 104-113
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Sébédio JL,Vermunt SH,Chardigny JM,Beaufrère B,Mensink RP,Armstrong RA,Christie WW,Niemelä J,Hénon G,Riemersma RAdoi
10.1038/sj.ejcn.1600903subject
Has Abstractpub_date
2000-02-01 00:00:00pages
104-13issue
2eissn
0954-3007issn
1476-5640journal_volume
54pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVE:To test the effect of supplementation of diet with ascorbic acid, selenium, alpha-tocopherol and beta-carotene on the oxidation resistance of very low (VLDL) + low density lipoprotein (LDL). DESIGN:A randomized placebo-controlled double-masked clinical trial. SETTING:In healthy men aged 30-58 years smoking ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVES:Application of a HPLC (high performance liquid chromatography) method, using cyanide derivatisation, to the determination of plasma pyridoxal-5-phosphate (PLP) concentrations as an indicator of vitamin B6 adequacy. SETTING:The study was performed at the Institute of Food Research, Norwich, UK. Blood samples...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600775
更新日期:1999-06-01 00:00:00
abstract::It has been hypothesized that the increased risk of obesity among African Americans may be partially explained by low energy expenditure (EE) and impaired fat oxidation. Twelve White adults without obesity were pair-matched by age, sex and body mass index (BMI) to a sample of 12 African Americans. Resting EE (REE), 24...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0202-2
更新日期:2018-06-01 00:00:00
abstract::Despite many methodological difficulties, studies evaluating the relationship between being small for gestational age (SGA) at birth and various measures of adverse neurologic outcome generally show significant associations. Nevertheless, cerebral palsy is rarely found in SGA infants. Minimal neurologic dysfunction is...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract::Alcohol-induced hypoglycaemia is a well-known phenomenon in insulin-treated diabetic subjects. Less attention has been paid to the impact of alcohol on blood glucose and insulin responses in non-insulin dependent diabetic subjects. The aim of this study was to investigate the acute metabolic effects of different alcoh...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-09-01 00:00:00
abstract::Consumers and patients are unsure of whom to trust for nutritional advice. Although medical doctors are seen as experts in nutrition and their advice is regularly followed, data are lacking on the amount of nutrition education in European medical school curricula. In line with US research, we distributed a survey on r...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.75
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To objectively measure rates of breast-feeding to infants born in a baby-friendly hospital in Bangalore, India, and to capture home-based compliance to exclusive breastfeeding (EBF). SUBJECTS/METHODS:Breast-milk (BM) and non-breast-milk (NBM) water intake were assessed in 50 mother-infant pairs u...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.179
更新日期:2012-04-01 00:00:00
abstract::The purpose of this paper is to assess the food habits of the Spanish population and the composition of the fat consumed. The national food survey data have been used. This survey was carried out during one week in a representative sample of households by means of recorded weighing or the household measures method. Th...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:To compare dietary fat intake, the accuracy of individuals' awareness about their fat intake, and sociodemographic and psychosocial correlates of awareness, in Dutch and American samples of employed adults. A discrepancy between objective dietary intake data and subjective self-evaluation of dietary fat cons...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600442
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:We set up a baseline data on urinary iodine excretion from a nationwide representative sample of rural schoolchildren before instituting iodine supplementation. DESIGN:Stratified multistage cluster sampling in three different strata: lowlands, foothills and mountainous areas. Early morning urine samples were...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600562
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. DESIGN:Randomized, diet-controlled, cross-over study. SETTING:The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. SUBJECTS:Ten middle-aged men and 10 postmen...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601459
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To determine whether dairy fat in cheese raises low-density lipoprotein (LDL) cholesterol as much as in butter, since epidemiology suggests a different impact on cardiovascular disease. DESIGN:A randomised crossover trial testing the daily consumption of 40 g dairy fat as butter or as matured cheddar cheese,...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602211
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To calculate intra-cluster and intra-household design effects and intra-class correlation coefficients for dietary nutrients obtained from a 24 h record-assisted recall. DESIGN:Children were recruited using clustered probability sampling. Randomly selected starting-point addresses were obtained with probabil...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602618
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet can affect the acid-base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 chronic kidney diseas...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0689-1
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Children born to human immunodeficiency virus (HIV)-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. The objective of this study was to identify maternal, socioeconomic and child...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2012.136
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The majority of hospital outpatients with undernutrition is unrecognized, and therefore untreated. There is a need for an easy and valid screening tool to detect undernutrition in this setting. The aim of this study was to determine the diagnostic accuracy of the MUST (Malnutrition Universal Scree...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/ejcn.2013.85
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the use of a self-administered quantitative food frequency questionnaire (QFFQ) in a national dietary survey concerning (a) response rates with different distribution methods and reward; (b) degree of underreporting of energy intake; (c) reproducibility of the QFFQ; and (d) seasonal variation on ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600410
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Recent epidemiological data have shown that abdominal fat accumulation is associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This study aimed to investigate the association between visceral adiposity and coronary artery calcification (CAC) in CKD ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.66
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To determine the nature of the relationship between mid-upper arm circumference (MUAC) and maximum voluntary contraction (MVC) in pre- and post-harvest seasons among adult Ethiopian farmers. SUBJECTS/METHODS:A total of 491 healthy adult men aged 18-60 years were recruited at pre-harvest season and followed ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602966
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:There are still controversies as to the potential beneficial effects of milk and fermented milk products on the level of lipoproteins. The objective of the present investigation was to test the effect of a moderate daily intake of a new fermented milk product, which was based on a bacterial culture obtained f...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:To assess the influence of a low-fat, low-energy diet on the intake of vitamins and minerals in patients with overweight and hyperlipidemia. SETTING:Outpatient clinic for hyperlipidemia treatment. SUBJECTS:A total of 134 subjects chosen from patients attending Outpatient Clinic of Metabolic Diseases. INTE...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601467
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous research has shown, in predominantly European populations, that dietary patterns are evident early in life. However, little is known about early-life dietary patterns in Australian children. We aimed to describe dietary patterns of Australian toddlers and their associations with socio-dem...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/ejcn.2013.23
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To investigate (i) associations of intimate partner violence (IPV) and chronic undernutrition among women of reproductive age and (ii) whether women who experience both poverty and IPV are unique in their nutritional disadvantages. SUBJECTS/METHODS:This study used the data from the 2007 Banglades...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.202
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults. DESIGN:A double-blind, placebo-controlled, crossover human study. SETTING:Food Microbial Sciences Unit, The University of Reading, Reading, UK. SUBJECTS:Thirty healthy volunteers, 15 men, 15 women (age range 19-35). INTERVEN...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602636
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:To examine the effects of physical activity (PA) in adults with or without prehypertension at baseline on systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension risk by gender. METHODS:A total of 5986 men and 6525 women (≥18 years old) without hypertension-related disease at baselin...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0653-0
更新日期:2020-05-13 00:00:00
abstract:BACKGROUND/OBJECTIVES:There is limited published research examining lipid-soluble vitamins in human immunodeficiency virus (HIV)-infected pregnant women, particularly in resource-limited settings. SUBJECTS/METHODS:This is an observational analysis of 1078 HIV-infected pregnant women enrolled in a trial of vitamin supp...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2010.76
更新日期:2010-08-01 00:00:00
abstract::Green tea is commonly consumed in China, Japan, and Korea and certain parts of North Africa and is gaining popularity in other parts of the world. The aim of this review was to objectively evaluate the existing evidence related to green tea consumption and various health outcomes, especially cancer, cardiovascular dis...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/s41430-020-00710-7
更新日期:2020-08-20 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aim of the study was to describe a novel dietary assessment strategy based on two instruments complemented by information from an external population applied to estimate usual food intake in the large-scale multicenter German National Cohort (GNC). As proof of concept, we applied the assessmen...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0383-8
更新日期:2019-11-01 00:00:00
abstract::This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. Prospective cohort studies that reported relative risks (RR) with 95%...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:10.1038/ejcn.2012.5
更新日期:2012-03-01 00:00:00
abstract::Urea kinetics was measured in a single woman on five occasions over four years by the prime/intermittent oral-dose method with [15N15N]-urea. On a nitrogen intake of 231 +/- 24 mg/kg/day, urea production was 198 +/- 22 mg/kg/day, with the urinary excretion of urea being 143 +/- 25 mg/kg/day. Urea hydrolysis and salvag...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00