Abstract：
BACKGROUND/OBJECTIVES:The aim of this study is to determine whether vitamin D status is associated with incident urinary incontinence (UI) among community-dwelling older adults. SUBJECTS/METHODS:The University of Alabama at Birmingham Study of Aging is a prospective cohort study of community-dwelling Medicare enrollees. Standardized assessment of UI was conducted using the validated Incontinence Severity Index. The analysis of 25-hydroxyvitamin D [25(OH)D] levels was performed on stored baseline sera. UI was assessed every 6-12 months for up to 42 months. The analyses included multivariable logistic regression and Cox proportional hazard models. RESULTS:Of 350 participants (175 male, 147 black, mean age 73.6±5.8), 54% (189/350) were vitamin D deficient (25(OH)D <20 ng/ml) and 25% (87/350) were vitamin D insufficient (25(OH)D: 20 ng/ml to <30 ng/ml). Among the 187 subjects with no UI at baseline, 57% (107/187) were vitamin D deficient and 24% (45/187) were vitamin D insufficient. A total of 175 of the 187 subjects had follow-up evaluation for incident UI over 42 months, and incident UI occurred in 37% (65/175). After adjustment, cumulative incident UI at 42 months was associated with baseline vitamin D insufficiency (P=0.03) and demonstrated a trend association with deficiency (P=0.07). There was no association between baseline vitamin D status and the time to incident UI. CONCLUSIONS:These preliminary results support an association between vitamin D and incident UI in community-dwelling older adults. Future studies may target specific at-risk groups, such as men with BPH or women with pelvic floor disorders for evaluation of the impact of vitamin D supplementation on urinary symptoms.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Vaughan CP,Tangpricha V,Motahar-Ford N,Goode PS,Burgio KL,Allman RM,Daigle SG,Redden DT,Markland ADdoi
10.1038/ejcn.2016.20subject
Has Abstractpub_date
2016-09-01 00:00:00pages
987-9issue
9eissn
0954-3007issn
1476-5640pii
ejcn201620journal_volume
70pub_type
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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abstract：OBJECTIVES:To examine the frequency of street food consumption of people living in low-income settlements in Nairobi and the role of street foods in their daily diet and to reveal why people consume street foods rather than home-prepared foods. SETTING, SUBJECTS AND METHODS: A cross-sectional descriptive study was done...
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602768
更新日期：2008-06-01 00:00:00
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journal_title：European journal of clinical nutrition
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doi：
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pub_type： 杂志文章
doi：10.1038/ejcn.2017.28
更新日期：2017-09-01 00:00:00
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更新日期：2013-01-01 00:00:00
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doi：10.1038/ejcn.2011.60
更新日期：2011-08-01 00:00:00
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doi：
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journal_title：European journal of clinical nutrition
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doi：
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