Iodine deficiency alone cannot account for goitre prevalence among pregnant women in Modhupur, Bangladesh.

Abstract:

OBJECTIVE:We wished to determine the contributing causes of goitre among pregnant women in rural Bangladesh to provide baseline data before instituting iodine supplementation. DESIGN:All pregnant women in a subdistrict of Modhupur, Bangladesh were assessed for goitre size and were asked to give blood and urine samples for measurement of iodine status and thyroid hormones. SETTING:Field study in 72 villages in rural Modhupur. SUBJECTS:356 women at all stages of gestation. RESULTS:Total goitre prevalence was 99%, and 79% of the women had goitres of grade 2 or 3. Nevertheless, urinary iodine levels indicated only moderate iodine deficiency with 23% below 0.16 mumol/l and 62% below 0.39 mumol/l. Plasma thyroid-stimulating hormone was elevated in 19% of the women. Other dietary factors which could potentially contribute to goitre--vitamin A or selenium deficiency or intake of large amounts of thiocyanate-producing goitrogens--were found not to be a problem among these women. Multiple regression analysis of the causes of goitre, including measures of iodine status and anthropometric variables, could account for only 12% of the variability in goitre grade. CONCLUSIONS:High goitre prevalence can occur even in the absence of severe iodine deficiency. Therefore, iodine supplementation may not completely solve a community goitre problem.

journal_name

Eur J Clin Nutr

authors

Filteau SM,Sullivan KR,Anwar US,Anwar ZR,Tomkins AM

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

293-302

issue

4

eissn

0954-3007

issn

1476-5640

journal_volume

48

pub_type

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