Abstract：
BACKGROUND/OBJECTIVES:The purpose of our study was to explore the relation of prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood in consecutive generations. SUBJECTS/METHODS:A total of 960 families, including 1920 parents (F1) who were born near the time of the Great Chinese famine and 1145 of their offspring (F2), were selected from the Suihua rural area. Parental participants were defined as nonexposed (born between 1 October 1956 and 30 September 1958 or between 1 October 1962 and 30 September 1964) and famine exposed (born between 1 October 1959 and 30 September 1961). In F2, participants were divided into having no parents exposed to famine, only a mother exposed to famine, only a father exposed to famine or both parents exposed to famine. Metabolic syndrome was defined by the International Diabetes Federation criteria. RESULTS:Exposure to famine during gestation was associated with an increased risk of metabolic syndrome (odds ratio: 2.79, 95% confidence interval: 2.16, 3.60) in F1 adults. However, similar association was not observed (maternal: odds ratio: 1.33, 95% confidence interval: 0.69, 2.52; paternal: odds ratio: 1.67, 95% confidence interval: 0.87, 3.21; parental: odds ratio: 1.25, 95% confidence interval: 0.68, 2.31) in F2 adults. CONCLUSIONS:Exposure to the Chinese famine during foetal life was associated with an increased risk of metabolic syndrome in F1 participants. In F2 adults, there might be an important relationship between exposure to famine and the risk of metabolic syndrome with increasing age.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Yan S,Hou W,Wu H,Jiang W,Li Y,Zhang Y,Li H,Yang S,Sun C,Han T,Li Ydoi
10.1038/s41430-020-0561-3subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1229-1236issue
8eissn
0954-3007issn
1476-5640pii
10.1038/s41430-020-0561-3journal_volume
74pub_type
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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abstract：:The validity of [15N]glycine and [13C]leucine as tracers for investigating albumin fractional synthetic rate (FSR) has been explored by simultaneous infusion of both amino acids into 5 normal female subjects. Albumin FSR, calculated from the urinary [15N]urea plateau value and the incorporation of arginine into albumi...
journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：OBJECTIVE:To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. DESIGN:A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioecon...
journal_title：European journal of clinical nutrition
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doi：10.1038/ejcn.2009.99
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abstract：:The present study was conducted to test the efficacy of fibre supplementation for hypercholesterolaemia in subjects from the desert Nomads. Ten males (53 +/- 8 years of age) participated in this study which consisted of three phases: baseline-1 period (2 weeks) in which subjects were on their normal, habitual dietary ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
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更新日期：1991-02-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：1988-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2011.221
更新日期：2012-05-01 00:00:00
abstract：:The pharmacokinetics of vitamin C following a 500 mg oral tablet dose were compared in a group of fourteen healthy young women whose age was 26.0 +/- 2.8 years (mean +/- s.d.), and in a group of fourteen healthy elderly women aged 68.1 +/- 2.6 years. The body composition of each subject was assessed using several anth...
journal_title：European journal of clinical nutrition
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doi：
更新日期：1990-06-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600456
更新日期：1997-09-01 00:00:00
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doi：10.1038/sj.ejcn.1601651
更新日期：2003-09-01 00:00:00
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journal_title：European journal of clinical nutrition
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doi：
更新日期：1994-07-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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更新日期：2016-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
