Abstract:
BACKGROUND:The relationship between hydrogen and methane production is a possible confounding factor in the interpretation of H(2) breath tests (HBT), but is usually disregarded for the interpretation of HBT and, in most instances, only H(2) excretion is measured. The present study was designed to evaluate the effect of predominant fasting methane CH(4) or H(2) production on the outcome of lactose HBT, in a large, homogeneous series of adult patients with irritable bowel syndrome (IBS). PATIENTS AND METHODS:A lactose HBT was performed in 237 IBS patients with predominant fasting methane production (CH(4)>H(2)), recording the outcome of the test, amount of gas excreted and occurrence of clinical symptoms. Data were compared to those of 237 age- and sex-matched IBS patients with low fasting CH(4) excretion. RESULTS:The test was positive in 124 predominant CH(4) producers (52.3%) (PMP), as compared to 201 (84.8%) low methane producers (LMP) (P<0.0001). Peak hydrogen concentration and area under the curve of H(2) were significantly (P<0.001) lower, and the occurrence of symptoms during the test less frequent, in PMP vs LMP patients. During the test, CH(4) excretion doubled in 57/113 (50.4%) patients with negative HBT, and in 49/124 (39.5%) with positive HBT. CONCLUSIONS:Patients with predominant fasting methane production excrete less H(2) than LMP, after an oral load of lactose. The lower prevalence of severe lactose intolerance in PMP, as well as lower incidence of symptoms during the test, is, indeed, related to lower and slower H(2) excretion. The assumption that H(2) excretion is an effective means of quantifying the amount of malabsorbed carbohydrates is questionable in PMP. Methane-producing patients likely have a higher 'false negative' rate as compared to LMP after an oral load of lactose. Nonetheless, as symptoms are related to the amount of gas produced in the colon, HBT identifies patients with 'lactose intolerance', irrespective of the presence of lactose malabsorption, and helps in predicting the effect of lactose-restricted diet.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Vernia P,Camillo MD,Marinaro V,Caprilli Rdoi
10.1038/sj.ejcn.1601651subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1116-9issue
9eissn
0954-3007issn
1476-5640pii
1601651journal_volume
57pub_type
杂志文章abstract:OBJECTIVES:The aim of this study was to assess how the glycaemic potency (blood glucose (BG)-raising potential) of breakfast is associated with cognitive function (CF) in school children, taking into account important confounders, including iron status, underlying physiological adaptations and socio-economic status. M...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.96
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies e...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602321
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. SUBJECTS/METHODS:The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.127
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:Few published data are available on the feeding practice of younger children in Tibet. Our study investigated feeding pattern of younger Tibetan children. DESIGN AND SUBJECTS:The study was a cross-sectional survey conducted in Tibet. A sample of 1655 children younger than 36 months old and their mothers was ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602207
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Adult skeletal muscle mass (SMM) protects against type 2 diabetes, but little is known about its developmental antecedents. We examined whether pace of early weight gain predicted adult SMM in a birth cohort from Cebu City, Philippines. In addition, we examined whether increases in SMM associated ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.18
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of cold storage and vinegar addition on glycaemic and insulinaemic responses to a potato meal in healthy subjects. SUBJECTS AND SETTING:A total of 13 healthy subjects volunteered for the study, and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, S...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ejcn.1602238
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) with disability and frequency of relapses in relapsing-remitting multiple sclerosis (MS) patients. SUBJECTS/METHODS:The study included 184 patients with relapsing-remitting MS who were receiving immune-mo...
journal_title:European journal of clinical nutrition
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abstract:BACKGROUND/OBJECTIVES:Health education and regulatory measures may contribute to lower population salt intake. Therefore, we aimed to describe knowledge and behaviors related to salt intake in Mozambique. SUBJECTS/METHODS:A cross-sectional evaluation of a representative sample of the population aged 15-64 years (n = 3...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0125-y
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abstract::Over the past three decades, undernutrition in Thailand has drastically reduced by over seven times. However, since 1995 the number of patients afflicted with non-communicable diseases, such as diabetes mellitus, has rapidly increased, even among the young. Unhealthy life styles due to urbanization are a major reason ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.28
更新日期:2014-10-01 00:00:00
abstract::Nutrition affects the brain throughout life, with profound implications for cognitive decline and dementia. These effects are mediated by changes in expression of multiple genes, and responses to nutrition are in turn affected by individual genetic variability. An important layer of regulation is provided by the epige...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究,评审
doi:
更新日期:1994-11-01 00:00:00
abstract::Insulin resistance is a condition of gluco-metabolic sufferance that may hesitate in the further development of type 2 diabetes and cardiovascular disease. The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in the youngest promo...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
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abstract:BACKGROUND/OBJECTIVES:The risk factors for metabolic syndrome may differ between Western and Asian countries due to their distinct dietary cultures. However, few studies have directly compared macronutrient intake and its association with the risk of metabolic syndrome in the US and Korean adults using national survey ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-017-0031-8
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.73
更新日期:2015-09-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:1998-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Disruptions in redox balance lead to oxidative stress, a promoter of morbidity in critical illness. This study aimed to: (1) characterize the plasma and alveolar thiol/disulfide redox pools, (2) examine their associations with alveolar macrophage phagocytosis, and (3) determine the effect of high ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2006-07-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602398
更新日期:2006-07-01 00:00:00
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更新日期:2014-05-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-11-01 00:00:00
abstract::Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral deficiencies are all common following...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1600669
更新日期:1998-12-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 历史文章,杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600611
更新日期:1998-08-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601378
更新日期:2002-07-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00