Abstract：
OBJECTIVE:Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies examining the possibility that folate status may affect plasma DHA concentrations. The objective of this study is to determine if the blood concentrations of folate and DHA are correlated in humans. DESIGN:Retrospective study. SETTING:An American research hospital. SUBJECTS:A total of 15 normal and 22 hostile and aggressive subjects, with a mean age of 38 years. METHODS:Concentrations of plasma polyunsaturated essential fatty acids and red blood cell folate (RBC folate) were obtained prior to 1996, before American flour was enriched with folate. RESULTS:RBC folate was significantly correlated with plasma DHA, r=0.57, P=0.005 in the aggressive group. Age, smoking and alcohol consumption did not alter the results. No other essential fatty acids were significantly associated with RBC folate in either group. CONCLUSIONS:The positive relationship between plasma DHA and RBC folate concentrations suggests that these two nutrients should be examined together in order to make the most accurate inferences about their relative contributions to disease pathogenesis. Our findings present one explanation why some conditions associated with hostility and low DHA status, such as cardiovascular disease and emotional disorders, are also associated with low folate status. SPONSORSHIP:National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Umhau JC,Dauphinais KM,Patel SH,Nahrwold DA,Hibbeln JR,Rawlings RR,George DTdoi
10.1038/sj.ejcn.1602321subject
Has Abstractpub_date
2006-03-01 00:00:00pages
352-7issue
3eissn
0954-3007issn
1476-5640pii
1602321journal_volume
60pub_type
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journal_title：European journal of clinical nutrition
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abstract：:Hydrolysed yeast protein labelled with 15N was used to measure protein turnover, protein synthesis and protein breakdown in preterm infants. The yeast tracer was given as a bolus intragastric dose and protein turnover was determined from the 15N enrichment of urinary ammonia over known periods of about 12 h. Six boys ...
journal_title：European journal of clinical nutrition
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abstract：BACKGROUND/OBJECTIVES:Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or parent-offspring studies. However, data on relative contribution of environmental factors on familial clustering of 25(OH)D in extended families are limited. SUBJECTS/METHODS:We performed cross-sect...
journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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abstract：OBJECTIVE:Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602398
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析,评审
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-05-01 00:00:00
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更新日期：2011-07-01 00:00:00
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600528
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600677
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-02-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2007-02-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：European journal of clinical nutrition
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doi：
更新日期：1996-03-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2013-05-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2010-08-01 00:00:00
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journal_title：European journal of clinical nutrition
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