Long-term changes in gut hormones, appetite and food intake 1 year after subtotal gastrectomy with normal body weight.

Abstract:

BACKGROUND/OBJECTIVES:No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)(3-36) levels. SUBJECTS/METHODS:Eighteen patients with early gastric cancer underwent subtotal gastrectomy with Billroth I reconstruction. We assessed appetite, food intake, body composition, and ghrelin and PYY(3-36) levels preoperatively and 1 year after surgery. RESULTS:There were no significant difference in the preoperative daily food intake and 1 year after subtotal gastrectomy. Weight loss occurred in all study subjects; 11.7% (n=2), 55.5% (n=10) and 33.3% (n=6) of the patients lost <5%, 5-10% and >10% of their preoperative body weight, respectively. Body mass index, waist circumference and body fat significantly decreased 1 year after subtotal gastrectomy. There were no significant differences in the appetite visual analogue scale preoperatively and 1 year after subtotal gastrectomy. The plasma ghrelin concentration decreased significantly (P=0.006), whereas PYY(3-36) did not show a significant change 1 year after subtotal gastrectomy. CONCLUSIONS:Ghrelin levels and body fat decreased significantly, whereas PYY(3-36) levels as well as appetite and food intake did not change significantly 1 year after subtotal gastrectomy with normal body weight. These findings suggest that decreased ghrelin might contribute directly to reduced body fat.

journal_name

Eur J Clin Nutr

authors

Jeon TY,Lee S,Kim HH,Kim YJ,Lee JG,Jeong DW,Kim YJ

doi

10.1038/ejcn.2010.83

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

826-31

issue

8

eissn

0954-3007

issn

1476-5640

pii

ejcn201083

journal_volume

64

pub_type

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