A study of protein turnover in preterm neonates using 15N enrichment of urinary ammonia.

Abstract:

:Hydrolysed yeast protein labelled with 15N was used to measure protein turnover, protein synthesis and protein breakdown in preterm infants. The yeast tracer was given as a bolus intragastric dose and protein turnover was determined from the 15N enrichment of urinary ammonia over known periods of about 12 h. Six boys (birthweight less than 1500 g) with gestation of 27-35 weeks were studied either two or three times at post-natal ages ranging from 13 to 54 d. There was no significant correlation between protein turnover with increasing post-conceptional or post-natal age. There was considerable interindividual variation and reproducibility varied between different infants. We suggest that this is a convenient non-invasive technique for monitoring serially nitrogen and protein metabolism in infants and that as such it merits further assessment.

journal_name

Eur J Clin Nutr

authors

Stack T,Reeds P,Preston T,Hay S,Lloyd DJ,Aggett PJ

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

231-4

issue

3

eissn

0954-3007

issn

1476-5640

journal_volume

44

pub_type

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