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Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial.

Abstract：

BACKGROUND/OBJECTIVES:Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabetic patients have been observed in our previous studies. This long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetics. SUBJECTS/METHODS:In this 2-year randomized clinical, parallel design study, 24 type 1 diabetics were enrolled and divided into two groups. Group I (n=12) received usual care, that is, diet, exercise and insulin and Group II (n=12) received 500 ml camel milk in addition to the usual care. Insulin requirement was titrated weekly by blood glucose estimation. Results were analyzed by using the regression technique. RESULTS:In camel milk group, there was decrease in mean blood glucose (118.58±19-93.16±17.06 mg/dl), hemoglobin A1c levels (7.81±1.39-5.44±0.81%) and insulin doses (32.50±9.99-17.50±12.09 U/day, P<0.05). Out of 12 subjects receiving camel milk, insulin requirement in 3 subjects reduced to zero. There was nonsignificant change in plasma insulin and anti-insulin antibodies in both the groups. CONCLUSION:It may be stated that camel milk is safe and efficacious in improving long-term glycemic control, with a significant reduction in the doses of insulin in type 1 diabetic patients.

journal_name

Eur J Clin Nutr

journal_title

European journal of clinical nutrition

authors

Agrawal RP,Jain S,Shah S,Chopra A,Agarwal V

doi

10.1038/ejcn.2011.98

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1048-52

issue

9

eissn

0954-3007

issn

1476-5640

pii

ejcn201198

journal_volume

65

pub_type

杂志文章,随机对照试验

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