Abstract：
OBJECTIVE:The hypothesis was tested that the rate of postmenopausal bone loss is inversely associated with long-term urinary excretion of phyto-oestrogens, as a marker of habitual dietary intake. DESIGN:Secondary analysis of a 10-year follow-up study (1979 1989) among postmenopausal women in the Netherlands. SUBJECTS:From the original population of 154 women, 32 women were selected with an annual rate of radial bone loss of < or = 0.5% over the first 5 years of the study and 35 women with a rate of > or = 2.5% per year. METHODS:The isoflavonoids genistein, daidzein and equol, and the lignan enterolactone were determined by gas chromatography mass spectrometry in aggregate samples from annually collected urine samples. Cortical bone density of the radius had previously been measured annually by single-photon absorptiometry. RESULTS:Excretion of isoflavonoids did not differ between both groups, although in multivariate analysis equol excretion was weakly positively associated with rate of bone loss in the 5 years after the menopause. Enterolactone excretion was significantly higher in the group with high rate of bone loss. This positive association remained in multivariate linear regression analysis after adjustment for age, years since menopause, body mass index and intake of calcium, vegetable protein and dietary fibre. CONCLUSIONS:Enterolactone excretion is likely to be an indicator of consumption of grains and legumes; it is not clear whether the observed positive association with rate of bone loss is a causal one. Our results do not support a preventive effect of low, unsupplemented dietary intake of phyto-oestrogens on postmenopausal cortical bone loss. However, no conclusions can be drawn about effects of higher doses of phyto-oestrogens.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Kardinaal AF,Morton MS,Brüggemann-Rotgans IE,van Beresteijn ECdoi
10.1038/sj.ejcn.1600659subject
Has Abstractpub_date
1998-11-01 00:00:00pages
850-5issue
11eissn
0954-3007issn
1476-5640journal_volume
52pub_type
杂志文章abstract：OBJECTIVE:To evaluate in 14 healthy volunteers the gastrointestinal tolerance to an indigestible bulking sweetener containing fructo-oligosaccharides (FOS). DESIGN:In order to mimic their usual pattern of consumption, FOS were ingested throughout the day either occasionally (once a week, first period) or regularly (ev...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:To evaluate glycaemic and insulinaemic index and in vitro digestibility of the five most common Cameroonian mixed meals consisting of rice+tomato soup (diet A), bean stew+plantains (B), foofoo corn+ndolé (C), yams+groundnut soup (D), and koki beans+cassava (E). SUBJECTS:Ten healthy non-obese volunteers, aged...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601592
更新日期：2003-04-01 00:00:00
abstract：OBJECTIVE:Elevated hearing thresholds have been demonstrated in populations afflicted by endemic cretinism as a result of severe iodine deficiency. However, data on the effects of less severe iodine deficiency on hearing thresholds in apparently normal children are scant. This study addresses the question whether there...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601220
更新日期：2001-09-01 00:00:00
abstract：:Dietary energy restriction is the only proven method for extending lifespan and slowing aging in mammals, while maintaining health and vitality. Although the first experiments in this area were conducted over 60 y ago in rodents, possible applicability to primates has only been examined in controlled studies since 198...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601020
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVES:Pregnant women in developing countries might be at risk of trace element deficiencies. These deficiencies could have deleterious effects on fetus. Therefore, serum trace elements were determined at delivery in Zairian mothers and their newborns. DESIGN:Prospective study. SETTING:Maternity ward of Kinshasa ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:To assess the carotenoid status in young type I diabetic patients and its relationship to the glycaemic control of the disease. DESIGN:A follow-up study. SETTING:Hospital Universitario Puerta de Hierro, Health Area VI of Madrid (Spain). SUBJECTS:Forty-seven type I diabetic patients, followed for 2.5 years....
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602411
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Observational studies document the inverse relationship between cardiovascular disease (CVD) and moderate alcohol intake. However, the causal role for alcohol in cardioprotection remains uncertain as such protection may be caused by confounders and misclassification. The aim of our study was to ev...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.61
更新日期：2010-06-01 00:00:00
abstract：:The paper reviews the evidence to date on the nutritional links with productivity and then goes on to provide results from a multi-country study on the effects of increasing body mass index (BMI) on productivity. The research relating nutritional status to work capacity is more consistent than the research linking nut...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:Nutrition education for medical students in the University of Otago, New Zealand, has been adapted to comply with the newly introduced system-based teaching. Clinical cases provide the focus for class demonstrations, tutorials, self-directed learning and a limited number of lectures. In the preclinical curriculum nutr...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600805
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:The EURRECA (EURopean micronutrient RECommendations Aligned) Network of Excellence collated current micronutrient recommendations. A user-friendly tool, Nutri-RecQuest, was developed to allow access to the collated data and to create a database source for use in other nutritional software tools. METHODS:Rec...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.60
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To study the effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly healthy subjects. SUBJECTS:The study included 29 healthy elderly subjects aged 60-81 years. METHODS:Prospective, randomized, double-blind and placebo-controlled, with a crossover design. The study includ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602898
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVES:To describe the intake of vitamins thiamine (B1), riboflavin (B2), B6 (pyridoxine), B12 (cobalamine) and C (ascorbic acid) and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS:Between 1995 and 2000, 36...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.78
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:This pilot study investigates the efficacy of a probiotic consortium (Lab4) in combination with vitamin C on the prevention of respiratory tract infections in children attending preschool facilities. SUBJECTS/METHODS:In a double-blind, randomised, placebo-controlled pilot study with children aged 3-6 years,...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2014.174
更新日期：2015-03-01 00:00:00
abstract：:The nutritional impact of a water and sanitation intervention in a rural community of Bangladesh, comprising the provision of handpumps, construction of latrines and hygiene education was assessed. During 3 years, the quarterly anthropometric measures of about 200 children aged 12-35 months from the intervention commu...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:Patterns of seasonal variation in energy intake among small scale farmers (n = 112 individuals) of the highland community of Nuñoa, Peru are examined. Marked seasonal fluctuations in energy consumption are demonstrated with average daily energy intakes being lowest during the last few months before harvest (January-Ap...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVES:To investigate the effect of three different food ingredients tyrosine, green tea extract (GTE) and caffeine on resting metabolic rate and haemodynamics, and on ad libitum energy intake (EI) and appetite. METHODS:Twelve healthy, normal weight men (age: 23.7 +/- 2.6 years, mean +/- s.d.) participated in a fo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602901
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important sit...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.32
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To determine whether dairy fat in cheese raises low-density lipoprotein (LDL) cholesterol as much as in butter, since epidemiology suggests a different impact on cardiovascular disease. DESIGN:A randomised crossover trial testing the daily consumption of 40 g dairy fat as butter or as matured cheddar cheese,...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602211
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVES:To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. SUBJECTS/METHODS:The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.127
更新日期：2010-10-01 00:00:00
abstract：:The present study tested the hypotheses that: (a) individual body composition estimates obtained with the Durnin-Womersley (D-W) equations have low validity in certain populations in developing countries; (b) there exists a poor relationship between the body mass index (BMI) and body composition estimates (fat mass (B...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：:The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2010.240
更新日期：2011-05-01 00:00:00
abstract：:We conducted a mini-review of the literature, focusing on aging-related systemic inflammation and its association with vitamin D (VitD). As main findings, data indicate that inflammation in aging seems to have multiple origins, including immunosenescence, and from intestinal and adipose tissue, where VitD may modulate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.177
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602857
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:The study was designed to evaluate the vitamin D status in women of different physiological status of two socio-economic groups in Bangladesh. DESIGN:A cross-sectional study, using serum 25-hydroxyvitamin D (25-OHD), calcium, phosphorus and alkaline phosphatase activity. SETTING:Two regions of Bangladesh. T...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601284
更新日期：2002-01-01 00:00:00
abstract：:The basal metabolic rate (BMR) was determined in 14 pairs of monozygotic (MZ; 11 females, 3 males) and 12 pairs of dizygotic (DZ; 10 females, 2 males) twins, with mean ages of 22.7 and 26 years. Zygosity was confirmed using DNA fingerprinting. When BMR was expressed as kJ/d, kJ/kg/d and kJ/kg FFM/d significant intra-c...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVE:To examine the effect of low-dose fish oil supplementation on specific growth factors, purported to play a central role in lesion formation, and also on the total growth factor activity of serum, as assessed by the induction of DNA synthesis in cultured human arterial smooth muscle cells. DESIGN:Randomized p...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601076
更新日期：2000-09-01 00:00:00
abstract：:We have used B-mode (brightness-mode) ultrasound to investigate the fascial planes within subcutaneous fat at the triceps and abdominal sites in a group of 17 women attending a weight control group over a 12 month period. In most subjects there was a single intralipid fascial plane at each site. As the thickness of ad...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:The pharmacokinetics of vitamin C following a 500 mg oral tablet dose were compared in a group of fourteen healthy young women whose age was 26.0 +/- 2.8 years (mean +/- s.d.), and in a group of fourteen healthy elderly women aged 68.1 +/- 2.6 years. The body composition of each subject was assessed using several anth...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Obese infants are more susceptible to develop adulthood obesity and its related comorbidities. Previous studies have shown the presence of hormones and growth factors in maternal breast milk that may influence infant adiposity. The aim of this study was to investigate differences in concentrations...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.205
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the role of the C677T-MTHFR (methylenetetrahydrofolate reductase)-polymorphism (CC, CT and TT) for vascular complications in liver transplant recipients. DESIGN:Retrospective study. SETTING:Hepatology-Transplantation-Unit, Johann Wolfgang Goethe-University, Frankfurt am...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602699
更新日期：2008-03-01 00:00:00
