Abstract：
BACKGROUND/OBJECTIVES:There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important site of glucose disposal, the strength of its association with insulin sensitivity (IS) is unknown in the Indian population. SUBJECTS/METHODS:This was a cross-sectional study performed to assess the association of body fat, muscle and muscle function with IS in 51 young, healthy, nonobese Indian men with BMI ranging from 15 to 25 kg/m(2), using hyperinsulinemic euglycemic clamp method. RESULTS:The median IS was 5.32 (mg/(kg min))/(microU/ml), lower, upper quartile, 4.03, 6.56); (SI units: 4.25, lower, upper quartile, 3.22, 5.24 (micromol/(kg min))/(pmol/l)). A multiple linear regression of the natural log transformed value of IS on BMI and body muscle mass measured as the appendicular lean soft tissue (expressed as a percentage of body weight) explained 49% of the variance in IS. Independently, body fat percent and muscle (handgrip) strength showed significant bivariate correlations with IS (rho=-0.61, P<0.001; rho=0.32, P=0.027, respectively), although these variables did not enter into the multiple regression. CONCLUSIONS:BMI and body fat have been shown to be inversely related to IS at higher BMIs. This study indicates that a relative increase in BMI and reduced muscle mass and possibly function are also associated with reduced IS in lean Indian men.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Unni US,Ramakrishnan G,Raj T,Kishore RP,Thomas T,Vaz M,Kurpad AVdoi
10.1038/ejcn.2009.32subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1206-12issue
10eissn
0954-3007issn
1476-5640pii
ejcn200932journal_volume
63pub_type
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602211
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abstract：:A food frequency questionnaire (FFQ) was designed and validated for use in an epidemiological survey measuring coronary heart disease risk factors in British children. The questionnaire asked about the frequency of children's consumption of 35 food items over the previous month and was completed by parents/guardians. ...
journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0290-z
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To examine students' beverage choice in school, with reference to its contribution to students' intake of non-milk extrinsic (NME) sugars. SUBJECTS/METHODS:Beverage and food selection data for students aged 11-18 years (n=2461) were collected from two large secondary schools in England, for a con...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2015.158
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:To determine the origin of the poor digestibility of banana starch granules in the human small intestine. DESIGN:The subjects received the same experimental meal. SETTING:Nutrition Research Unit, Laënnec Hospital, CHU, Nantes. SUBJECTS:Six healthy young subjects. INTERVENTIONS:The digestion of raw green b...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
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abstract：BACKGROUND:The anthropometric measurement of mid-arm muscular area (MAMA) involves overestimation because of various assumptions, this overestimation being progressive with increasing adiposity. However, the effects of muscle atrophy and variation of the subcutaneous fat thickness have remained uncertain. OBJECTIVES:T...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.87
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Urinary and plasma indices are utilized to assess whole-body water balance in healthy adults, whereas the urine-to-plasma osmolality ratio (Uosm:Posm) rarely is. To explore the efficacy of Uosm:Posm as a hydration biomarker, diet records of 120 college women were analyzed (beverage water+food wate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.79
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:In spite of several studies relating dietary patterns to breast cancer risk, evidence so far remains inconsistent. This study aimed to investigate associations of dietary patterns derived with three different methods with breast cancer risk. SUBJECTS/METHODS:The Mediterranean Diet Score (MDS), pr...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2014.135
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To compare different possibilities of reporting the iodine supply in the same urine samples. Indeed, in field studies, urinary iodine concentration (I/L: micro g I/L, micro mol I/L, I/creatinine: micro g I/g creatanine, micro mol I/mol creatinine) is more readily available than excretion (I/24h micro g I/24 h...
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pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601740
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:There is increasing evidence to support that a high-protein diet may promote weight loss and prevent weight (re)gain better than a low-protein diet, and that the effect is due to higher diet-induced thermogenesis (DIT) and increased satiety. However, data on the effect of different types of protei...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2011.221
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Flavanols may provide protection against insulin resistance, but little is known about the amounts and types of flavanols that may be efficacious. SUBJECTS/METHODS:This study was designed to determine whether cocoa flavanols, over a range of intakes, improve biomarkers of glucose regulation, infl...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/ejcn.2012.101
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:This study investigates the predictors of serum cobalamin concentrations in community-dwelling older adults and the relationship between serum cobalamin and plasma homocysteine. SUBJECTS/METHODS:Serum cobalamin and plasma homocysteine were measured by SimulTRAC-SNB radio assay and HPLC, respectiv...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0367-8
更新日期：2019-09-01 00:00:00
abstract：:Chronic diseases and disabilities increase with age, affecting more than 60% of those over 75 y, and limiting activities in about half of them. Therefore, total energy expenditure (TEE) and its components are assessed separately in health and disease. An analysis of 568 doubly labelled water measurements in 'healthy' ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601030
更新日期：2000-06-01 00:00:00
abstract：OBJECTIVE:To assess the differential response of plasma, lymphocyte and neutrophil vitamin E levels to high-intensity physical activity and to vitamin C and E supplementation. SUBJECTS:In all, 14 male trained amateur runners (32-36 y old) were randomly divided in two groups (supplemented and placebo), and participated...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602143
更新日期：2005-06-01 00:00:00
abstract：:As part of the Euronut SENECA study, food consumption has been assessed in 1217 men and 1241 women, born between 1913 and 1918 and living in 18 towns in 12 European countries. The method used was a standardized modified dietary history, including a 3-day estimated record and a food frequency list based on local food p...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
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abstract：OBJECTIVE:To investigate the extent to which breast milk is replaced by intake of other liquids or foods, and to estimate energy intake of infants defined as exclusively (EBF), predominantly (PBF) and partially breast-fed (PartBF). DESIGN:Cross-sectional. SETTING:Community-based study in urban Pelotas, Southern Brazi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601735
更新日期：2003-12-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.74
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the role of the C677T-MTHFR (methylenetetrahydrofolate reductase)-polymorphism (CC, CT and TT) for vascular complications in liver transplant recipients. DESIGN:Retrospective study. SETTING:Hepatology-Transplantation-Unit, Johann Wolfgang Goethe-University, Frankfurt am...
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doi：10.1038/sj.ejcn.1602699
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更新日期：2010-06-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2017-09-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2013-02-01 00:00:00
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journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1600442
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pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602553
更新日期：2007-04-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.103
更新日期：2016-11-01 00:00:00
abstract：:The validity of [15N]glycine and [13C]leucine as tracers for investigating albumin fractional synthetic rate (FSR) has been explored by simultaneous infusion of both amino acids into 5 normal female subjects. Albumin FSR, calculated from the urinary [15N]urea plateau value and the incorporation of arginine into albumi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2015.98
更新日期：2015-11-01 00:00:00
