Abstract：
OBJECTIVE:To determine whether dairy fat in cheese raises low-density lipoprotein (LDL) cholesterol as much as in butter, since epidemiology suggests a different impact on cardiovascular disease. DESIGN:A randomised crossover trial testing the daily consumption of 40 g dairy fat as butter or as matured cheddar cheese, each of 4 weeks duration, was preceded by and separated by 2-week periods when dietary fat was less saturated. SETTING:Free-living volunteers. SUBJECTS:A total of 14 men and five women of mean age 56+/-8 y, with mean total cholesterol of 5.6+/-0.8 mmol/l. MAIN OUTCOME MEASURES:Plasma cholesterol, LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triacylglycerol and glucose. RESULTS:Saturated fat intake was significantly lower during the run-in than during the cheese and butter periods. Mean lipid values did not differ significantly between the cheese and run-in periods, but total cholesterol and LDL-C were significantly higher with butter: total cholesterol (mmol/l): butter 6.1+/-0.7; run-in 5.6+/-0.8 (P < 0.05; ANOVA with Bonferroni adjustment); vs cheese 5.8+/-0.6 (P > 0.05); median LDL-C (mmol/l): butter 3.9 (3.5-4.1) vs run-in 3.4 (3.0-4.1) (P < 0.05; Tukey test); vs cheese 3.7 (3.3-3.9) (P > 0.05). Among 13 subjects whose initial LDL-C was >4 mmol/l, the difference between butter (4.4+/-0.3 mmol/l) and cheese (3.9+/-0.3 mmol/l) was significant (P = 0.014). HDL-C was highest with butter and triacylglycerol with cheese (neither was significant). CONCLUSION:A total of 40 g dairy fat eaten daily for 4 weeks as butter, but not as cheese, raised total and LDL cholesterol significantly compared with a diet containing significantly less saturated fat. Dietary advice regarding cheese consumption may require modification.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Nestel PJ,Chronopulos A,Cehun Mdoi
10.1038/sj.ejcn.1602211subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1059-63issue
9eissn
0954-3007issn
1476-5640pii
1602211journal_volume
59pub_type
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
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abstract：OBJECTIVES:To evaluate the acceptance of a multinutrient liquid nutrition supplement in psycho-geriatric nursing home patients and the effect on weight, plasma nutrients and activities of daily life. DESIGN:Double-blind, placebo-controlled 12-week intervention study. SETTING:Two nursing homes in Boxtel, The Netherlan...
journal_title：European journal of clinical nutrition
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abstract：:The relevance of nutritional indices derived from comparison with growth standards to assess the risk of dying was evaluated in a 2-year prospective study in rural Senegal. An average of 3151 children aged 6-59 months were measured twice a year and followed up during the intervening 6-month periods. Children who survi...
journal_title：European journal of clinical nutrition
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abstract：:Nutrient profiling classifies individual food products according to their nutrient content. According to the WHO (World Health Organization), validation is a key step in the development of a nutrient profiling system. The aim was to assess the construct validity of five European nutrient profiling systems (Choices, Ke...
journal_title：European journal of clinical nutrition
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abstract：:More than 20 years of serological approach to diagnosis of celiac disease (CD) has deeply changed the classical clinical presentation of the disease, and some reports indicate that CD and obesity can coexist in both childhood and adolescence. We reviewed clinical records of 149 children with CD followed in our institu...
journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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abstract：BACKGROUND/OBJECTIVES:The purpose of our study was to explore the relation of prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood in consecutive generations. SUBJECTS/METHODS:A total of 960 families, including 1920 parents (F1) who were born near the time of the Great Chinese famine...
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
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更新日期：2012-01-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2003-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Low birth weight (LBW), defined as the body weight at birth of less than 2500 g, is a major public health problem in Bangladesh, where 37% of the babies are born with LBW. The objective of this study is to see the impact of nutrition education on growth of LBW babies with early initiation and excl...
journal_title：European journal of clinical nutrition
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abstract：OBJECTIVE:To assess the bioavailability of vitamins A and E administered parenterally with either water-soluble or lipid-soluble preparations. STUDY DESIGN:A water soluble preparation (MVI Pediatric) administered with a glucose-amino acid solution and a lipid soluble preparation (Vitalipid N Infant) infused with a lip...
journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1601417
更新日期：2002-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of clinical nutrition
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更新日期：2004-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-09-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：1997-09-01 00:00:00
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更新日期：2012-03-01 00:00:00
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journal_title：European journal of clinical nutrition
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更新日期：2015-01-01 00:00:00
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
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更新日期：2014-08-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2007-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0199-6
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:To study the relationship between consumption of milk and milk products, calcium, lactose and vitamin D and occurrence of colorectal cancers. DESIGN:Prospective cohort study. SUBJECTS:A total of 9959 men and women aged 15 y or older without history of cancer at baseline. During a 24 y follow-up, 72 new canc...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601260
更新日期：2001-11-01 00:00:00
abstract：OBJECTIVE:To assess the potential impact of a national iron supplementation programme in rural Vietnam. METHODS:The study included questionnaires, focus group discussions of pregnant women and key informant interviews, together with measurements of haemoglobin (Hb) and a stool examination for soil-transmitted helminth...
journal_title：European journal of clinical nutrition
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doi：10.1038/sj.ejcn.1602812
更新日期：2008-08-01 00:00:00
