Abstract:
OBJECTIVE:This study describes the prevalence and characteristics of an elevated resting energy expenditure (REE) in patients with chronic obstructive pulmonary disease (COPD). DESIGN AND SETTING:Patients were consecutively admitted to an in-patient pulmonary rehabilitation centre. SUBJECTS:The study group consisted of 172 (123 males) clinically stable patients with COPD, age mean (s.d.) 64(10) y). INTERVENTIONS:REE was assessed by indirect calorimetry (ventilated hood) and adjusted for the influence of fat-free mass (FFM; measured by bioelectrical impedance analysis) using the linear regression equations of REE on FFM generated in 92 healthy age-matched subjects (58 males, age 67(8) y) for men and women separately. The predicted REE adjusted for FFM (REEFFM) was obtained by using the FFM of each individual patient in the linear regression equation of REE on FFM generated in the healthy control group. RESULTS:26% of the patients were hypermetabolic (defined as REE > 110% REEFFM), characterized by a lower age (60 (10) vs 65 (9) y) and a lower total lung capacity (TLC; 122(27)vs 139(28) %pred) compared to normometabolic patients (P < 0.001). The prevalence of FFM-depletion was equal among normo- and hypermetabolic patients: 36% vs 33% respectively. Depleted patients expressed however a significantly higher residual volume/TLC ratio and a lower maximal inspiratory mouth pressure independently of hypermetabolism (P < 0.05). In contrast, on base of the Harris & Benedict (HB) prediction equations, which do not take body composition into account, 54% of the patients were hypermetabolic (REE > 110% REEHB), characterized by a higher age and a lower body mass and FFM (P < 0.05). CONCLUSIONS:Hypermetabolism commonly occurs in COPD, characterized by less hyperinflation at rest, in contrast to the suggested contribution of an elevated oxygen cost of breathing (OCB) to hypermetabolism in COPD. The higher hyperinflation at rest in FFM-depleted patients independently of hypermetabolism suggests a higher OCB during activities, contributing to the elevated total daily energy expenditure previously reported in COPD. The HB-equations overestimate the prevalence of hypermetabolism and link hypermetabolism incorrectly to aging and depletion.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Creutzberg EC,Schols AM,Bothmer-Quaedvlieg FC,Wouters EFdoi
10.1038/sj.ejcn.1600571subject
Has Abstractpub_date
1998-06-01 00:00:00pages
396-401issue
6eissn
0954-3007issn
1476-5640journal_volume
52pub_type
杂志文章abstract:OBJECTIVE:To investigate the separate and combined effect of wine-drinking and other alcoholic beverages on esophageal cancer, in a high wine-consuming population. DESIGN:Combined analysis of two hospital-based case-control studies. SETTING:Major teaching and general hospitals in the greater Milan area and in the pro...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601113
更新日期:2000-12-01 00:00:00
abstract::Hydrolysed yeast protein labelled with 15N was used to measure protein turnover, protein synthesis and protein breakdown in preterm infants. The yeast tracer was given as a bolus intragastric dose and protein turnover was determined from the 15N enrichment of urinary ammonia over known periods of about 12 h. Six boys ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous research has shown, in predominantly European populations, that dietary patterns are evident early in life. However, little is known about early-life dietary patterns in Australian children. We aimed to describe dietary patterns of Australian toddlers and their associations with socio-dem...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/ejcn.2013.23
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), may decrease the risk of preeclampsia, but many suffer from important methodological limitations. METHODS:We prospectively examined the association between fat intake during pregnancy and p...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0290-z
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of fatty liver and alanine aminotransferase (ALT) elevation in obese Japanese women and to clarify the factors contributing to fatty change and ALT elevation in the cohort. DESIGN:Cross-sectional and population-based study. SUBJECTS:From 4366 women who received their annual healt...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601956
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)(3-36) levels. SUBJECTS/MET...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.83
更新日期:2010-08-01 00:00:00
abstract::Aging is the major risk factor for the development of human neurodegenerative maladies such as Alzheimer's, Huntington's and Parkinson's diseases (PDs) and prion disorders, all of which stem from toxic protein aggregation. All of these diseases are correlated with cognitive decline. Cognitive Decline is a dynamic stat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2014.189
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To describe dietary carbohydrate intakes and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS:Between 1995 and 2000, 36 034 subjects, aged between 35-74 years, were administered a standardized, 24-h die...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.74
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To assess the validity of two diet quality indexes-food variety score (FVS) and diet diversity score (DDS) in Western Mali. DESIGN:In two separate studies (A and B), FVS and DDS were derived from a food frequency questionnaire (FFQ) and were compared with the same scores and with measures of nutrient adequac...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601686
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is well established that combining a reduced calorie, low-fat diet with the lipase inhibitor orlistat results in significantly greater weight loss than placebo plus diet. This weight loss is accompanied by changes in adipose tissue (AT) distribution. As 60 mg orlistat is now available as an ove...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章
doi:10.1038/ejcn.2011.108
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Dietary counseling and intervention based on application of conventional criteria have been ineffective in preventing the progressive weight loss associated with HIV infection. The aim of the study was to compare the progression of clinical and nutritional indicators during nutritional supplementation with or...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601276
更新日期:2001-12-01 00:00:00
abstract::Dialysis patients are at increased risk for muscle wasting, and time efficient screening tests are required for to allow for early detection. Creatinine kinetics have been advocated to estimate lean body mass (LBM) in peritoneal dialysis (PD) patients, and can be readily calculated in clinical practice from peritoneal...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-017-0072-z
更新日期:2018-10-01 00:00:00
abstract::Western dietary pattern, and particularly high dietary sodium intake (DSI), is recognized for its detrimental impact on blood pressure (BP). This paper examined the association of DSI with BP in Nunavik Inuit (Québec), a population known to have an optimal BP on average. In a population-based study, we recruited 421 n...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.8
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. DESIGN:A prospective...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602412
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of irregular meal frequency on circulating lipids, insulin, glucose and uric acid concentrations which are known cardiovascular risk factors. DESIGN:A randomised crossover dietary intervention study. SETTING:Nottingham, UK--Healthy free-living women. SUBJECTS:A total of nine lean ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601935
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:We hypothesized that very low birth weight (VLBW) infants have reduced serum and red blood cell (RBC) selenium (Se) at birth, which decrease further with current nutrition and are associated with chronic lung disease and septicaemia. DESIGN:We studied Se intake, concentration in serum and RBCs and glutathion...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602715
更新日期:2008-03-01 00:00:00
abstract::Dietary intake data of 43 Finnish rheumatoid arthritis patients were collected using 7-day food records. The subjects were randomized into a control and a vegan diet groups, consisting of 22 and 21 subjects, respectively. The subjects in the vegan diet group received an uncooked vegan diet ('living food') for 3 months...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Recent epidemiological data have shown that abdominal fat accumulation is associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This study aimed to investigate the association between visceral adiposity and coronary artery calcification (CAC) in CKD ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.66
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To examine the relationships between TNF-alpha, obesity, and insulin resistance among prepubescent children. DESIGN:Cross-sectional study. SETTING AND SUBJECTS:Data were collected from 112 nondiabetic Latino schoolchildren from public schools in three South Florida communities. Of the enrolled participants,...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601852
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Few studies in Latin American paediatric populations have differentiated fat deposits in specific areas, such as intra-abdominal fat (IAF) and subcutaneous abdominal fat (SAF). Research in diverse populations is needed, as patterns of fat accumulation vary by ethnicity. The aim of this study was to...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2017.28
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:We wished to determine the contributing causes of goitre among pregnant women in rural Bangladesh to provide baseline data before instituting iodine supplementation. DESIGN:All pregnant women in a subdistrict of Modhupur, Bangladesh were assessed for goitre size and were asked to give blood and urine samples...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:To investigate the possible differential role of refined and whole grain cereals on the risk of upper digestive and respiratory tract neoplasms. DESIGN:Hospital-based case-control study. SETTING:University Hospital of Lausanne, Switzerland. SUBJECTS:A total of 156 incident cases of cancers of the oral cavi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601043
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To assess the influence of a low-fat, low-energy diet on the intake of vitamins and minerals in patients with overweight and hyperlipidemia. SETTING:Outpatient clinic for hyperlipidemia treatment. SUBJECTS:A total of 134 subjects chosen from patients attending Outpatient Clinic of Metabolic Diseases. INTE...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601467
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Maternal dietary patterns were associated with embryonic growth and congenital anomalies. We aim to evaluate associations between early first trimester maternal dietary patterns and embryonic morphological development among pregnancies with non-malformed outcome. SUBJECTS/METHODS:A total of 228 s...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0161-7
更新日期:2018-12-01 00:00:00
abstract::In this issue we would like to thank all those listed below for taking the time to review for the European Journal of Clinical Nutrition in 2019-your generosity is much appreciated and we hope your association with the journal continues in the future. ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0589-4
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the major dietary patterns of two age cohorts of women, to determine to the extent to which the dietary patterns differ between the cohorts and to assess whether they vary according to sociodemographic and behavioural characteristics and patterns of nutrient intake. METHOD...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.121
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to validate BOD POD in a wide sample of healthy and independent Mexican elderly men and women subjects using the 4 compartment (4C) model as the reference method, and to evaluate the assumptions of the densitometric two-compartment (2C) model. DESIGN:Cross-sectional study designed...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602597
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVES:To examine the frequency of street food consumption of people living in low-income settlements in Nairobi and the role of street foods in their daily diet and to reveal why people consume street foods rather than home-prepared foods. SETTING, SUBJECTS AND METHODS: A cross-sectional descriptive study was done...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601183
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To investigate (i) associations of intimate partner violence (IPV) and chronic undernutrition among women of reproductive age and (ii) whether women who experience both poverty and IPV are unique in their nutritional disadvantages. SUBJECTS/METHODS:This study used the data from the 2007 Banglades...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.202
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/ejcn.2010.194
更新日期:2011-01-01 00:00:00