Abstract：
OBJECTIVE:To investigate the impact of irregular meal frequency on circulating lipids, insulin, glucose and uric acid concentrations which are known cardiovascular risk factors. DESIGN:A randomised crossover dietary intervention study. SETTING:Nottingham, UK--Healthy free-living women. SUBJECTS:A total of nine lean healthy women aged 18-42 y recruited via advertisement. INTERVENTION:A randomised crossover trial with two phases of 14 days each. In Phase 1, subjects consumed their normal diet on either 6 occasions per day (regular) or by following a variable meal frequency (3-9 meals/day, irregular). In Phase 2, subjects followed the alternative meal pattern to that followed in Phase 1, after a 2-week (wash-out) period. Subjects were asked to come to the laboratory after an overnight fast at the start and end of each phase. Blood samples were taken for measurement of circulating glucose, lipids, insulin and uric acid concentrations before and for 3 h after consumption of a high-carbohydrate test meal. RESULTS:Fasting glucose and insulin values were not affected by meal frequency, but peak insulin and AUC of insulin responses to the test meal were higher after the irregular compared to the regular eating patterns (P < 0.01). The irregular meal frequency was associated with higher fasting total (P < 0.01) and LDL (P < 0.05) cholesterol. CONCLUSION:The irregular meal frequency appears to produce a degree of insulin resistance and higher fasting lipid profiles, which may indicate a deleterious effect on these cardiovascular risk factors. SPONSORSHIP:: The Ministry of Health and Medical Education, IR Iran.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Farshchi HR,Taylor MA,Macdonald IAdoi
10.1038/sj.ejcn.1601935subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1071-7issue
7eissn
0954-3007issn
1476-5640pii
1601935journal_volume
58pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:We examined the relation between intake of natural dietary plant sterols and serum lipid concentrations in a free-living population. DESIGN, SETTING AND PARTICIPANTS:Cross-sectional population-based study of 22,256 men and women aged 39-79 y resident in Norfolk, UK, participating in the European Prospective ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601980
更新日期：2004-10-01 00:00:00
abstract：:Bioelectrical impedance analysis is an extremely popular method for assessment of body composition. Despite its wide-spread use over the past thirty years, its accuracy and clinical value is still questioned. Most frequently, criticisms focus on its purported poor absolute accuracy and that different impedance analyse...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/s41430-018-0335-3
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:To study the effect of Lactobacillus helveticus fermented milk on sleep and health perception in elderly healthy subjects. SUBJECTS:The study included 29 healthy elderly subjects aged 60-81 years. METHODS:Prospective, randomized, double-blind and placebo-controlled, with a crossover design. The study includ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602898
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Growth parameters during infancy and early childhood might predict adipokine levels later in life. This study investigates the association between peak growth velocities, body mass index (BMI) and age at adiposity rebound (AR), with leptin and adiponectin levels at age 10 years. SUBJECTS/METHODS:...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2013.213
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Fiber-rich diets have been proposed to lower circulating levels of inflammatory makers. Our objective was to investigate cross-sectional relationships between fiber intake and plasma fibrinogen. SUBJECTS/METHODS:We examined the relationship between plasma fibrinogen and dietary fiber in 20,960 me...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.194
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To explore the associations between serum concentrations of vitamin D (25(OH)D) and all-cause mortality among US adults defined by lung function (LF) status, particularly among adults with obstructive LF (OLF). METHODS:Data from 10,795 adults aged 20-79 years (685 with restrictive LF (RLF) and 1309 with OLF)...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.162
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Living in socioeconomically disadvantaged neighbourhoods is associated with increased risk of a poor diet; however, the mechanisms underlying associations are not well understood. This study investigated whether selected healthy and unhealthy dietary behaviours are patterned by neighbourhood-socio...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.174
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency (VDD) affects the health and wellbeing of millions worldwide. In high latitude countries such as the United Kingdom (UK), severe complications disproportionally affect ethnic minority groups. OBJECTIVE:To develop a decision-analytic model to estimate the cost effectiveness of population...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-019-0486-x
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Cross-sectionally, educational attainment is strongly associated with the prevalence of obesity, but this association is less clear for weight change during adult life. The objective of this study is to examine the association between educational attainment and weight change during adult life in t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2012.55
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:To explore the sociodemographic disparity in the nutritional status including BMI, vitamin D and vitamin A status among children and adolescents in Zhejiang Province. METHODS:Weight, height serum 25-hydroxyvitamin D, and serum retinol were assessed in 2818 children and adolescents (6-17 years of age), using ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00704-5
更新日期：2020-08-19 00:00:00
abstract：OBJECTIVE:To study the relation between indicators of infection and Schistosoma mansoni and S. haematobium infection, and serum concentrations of zinc, ferritin and retinol. DESIGN:Cross-sectional. SETTING AND SUBJECTS:313 rural Zimbabwean schoolchildren (144 boys and 169 girls, 11-17 years). VARIABLES:S. mansoni an...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVE:To evaluate in 14 healthy volunteers the gastrointestinal tolerance to an indigestible bulking sweetener containing fructo-oligosaccharides (FOS). DESIGN:In order to mimic their usual pattern of consumption, FOS were ingested throughout the day either occasionally (once a week, first period) or regularly (ev...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVE:To determine whether the age-related decrease in resting energy expenditure (REE) is explained by variations in body composition. DESIGN:In Study 1, adult subjects (20-70 years) from the Quebec Family Study were classified into five different age groups. Body composition was measured by hydrodensitometry to ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602262
更新日期：2006-01-01 00:00:00
abstract：:Evidence is accumulating that obesity risks become established early in life. The goal of this systematic review is to assess whether there is evidence that rapid postnatal growth holds different implications for childhood obesity risks for children who experienced different patterns of prenatal growth. We conducted s...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.258
更新日期：2017-08-01 00:00:00
abstract：:The objective of this study was to investigate whether a diet rich in legumes are associated with oxidative stress among type 2 diabetic patients. In a randomized, controlled, crossover clinical trial, 31 type 2 diabetic patients were randomly assigned to receive 2 diets, each for a period of 8 weeks: (1) The legume-f...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2017.113
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study is to determine whether vitamin D status is associated with incident urinary incontinence (UI) among community-dwelling older adults. SUBJECTS/METHODS:The University of Alabama at Birmingham Study of Aging is a prospective cohort study of community-dwelling Medicare enrollee...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.20
更新日期：2016-09-01 00:00:00
abstract：:We conducted a mini-review of the literature, focusing on aging-related systemic inflammation and its association with vitamin D (VitD). As main findings, data indicate that inflammation in aging seems to have multiple origins, including immunosenescence, and from intestinal and adipose tissue, where VitD may modulate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.177
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules. DESIGN:Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the du...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601231
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602857
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:To assess the relationship between maternal stress and distress in pregnancy and 5-8 years postpartum and child nutritional status. SUBJECTS/METHODS:Longitudinal cohort study carried out in Jundiai city, Southeast Brazil, involving 409 women followed throughout pregnancy to 5-8 years postpartum, a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.28
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To objectively measure rates of breast-feeding to infants born in a baby-friendly hospital in Bangalore, India, and to capture home-based compliance to exclusive breastfeeding (EBF). SUBJECTS/METHODS:Breast-milk (BM) and non-breast-milk (NBM) water intake were assessed in 50 mother-infant pairs u...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.179
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies e...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602321
更新日期：2006-03-01 00:00:00
abstract：:The purpose of this paper is to assess the food habits of the Spanish population and the composition of the fat consumed. The national food survey data have been used. This survey was carried out during one week in a representative sample of households by means of recorded weighing or the household measures method. Th...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:A high monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) intake is associated with lower plasma low-density lipoprotein (LDL)-cholesterol. However, PUFA may increase the susceptibility of LDL to undergo oxidative modifications. The aim of this study was to analyze the association of habi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602492
更新日期：2007-02-01 00:00:00
abstract：:Adult (primary) lactose malabsorption is practically universal in Africans of Bantu and San ('Bushmen') stock. Recent environmental changes, especially in rural areas, have exacerbated rates of malnutrition in hospital patients belonging to these groups. In order to assess the advisability of using milk as a nutrition...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To understand determinants of overweight, several studies addressed the association between neighbourhood characteristics and adult obesity. However, little is known about the association of such characteristics with adolescents' overweight. This study aims at the influence of neighbourhood charac...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.21
更新日期：2011-06-01 00:00:00
abstract：:Bias in diet reporting may be both random and non-random, and may be found with simpler as well as more advanced dietary instruments. A random bias will contribute to obscure relations between diet and disease. A systematic bias may obscure or aggravate such associations. Underreporting of non-protein energy has been ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602589
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602790
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of fatty liver and alanine aminotransferase (ALT) elevation in obese Japanese women and to clarify the factors contributing to fatty change and ALT elevation in the cohort. DESIGN:Cross-sectional and population-based study. SUBJECTS:From 4366 women who received their annual healt...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601956
更新日期：2004-09-01 00:00:00
abstract：OBJECTIVE:These two studies compared the subjective assessment of how filling a snack type would be, with actual consumption of that type of snack at a snack meal. DESIGN:Four snack types: savory high-fat, savory high-carbohydrate, sweet high-carbohydrate, each comprising of five food items, were used. Study 1 consist...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
