Abstract:
OBJECTIVE:A high monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) intake is associated with lower plasma low-density lipoprotein (LDL)-cholesterol. However, PUFA may increase the susceptibility of LDL to undergo oxidative modifications. The aim of this study was to analyze the association of habitual dietary fat intake with LDL size and oxidizability. DESIGN:Cross-sectional. SETTING:Cohort study. SUBJECTS:Seven hundred and fifty-eight subjects with normal, impaired glucose metabolism and type II diabetes. INTERVENTIONS:Mean LDL size was measured by high-performance gel-filtration chromatography. In vitro oxidizability of LDL was determined by measuring lag time, reflecting the resistance of LDL to copper-induced oxidation. Information about dietary fat intake was obtained by a validated food frequency questionnaire. RESULTS:PUFA intake (energy percent) was significantly and negatively associated with LDL size in subjects with type II diabetes (standardized beta (95% confidence interval) -0.17 (-0.28;-0.06)) and impaired glucose metabolism - although not statistically significant - (-0.09 (-0.24;0.05)), but not in subjects with normal glucose metabolism (0.01 (-0.10;0.12)) (P-value for interaction=0.02). No significant associations were observed for total, saturated fat and MUFA intake with LDL size. Intake of fat was associated with lag time; however, the small magnitude of the associations suggested that the composition of dietary fat is not a major factor affecting lag time. The same association with lag time was observed in all three glucose metabolism categories. CONCLUSIONS:In individuals with abnormal glucose metabolism, higher PUFA intake is associated with smaller LDL particle size, but does not alter the susceptibility of LDL to in vitro oxidation. SPONSORSHIP:Dutch Diabetes Research Foundation, and the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Bos G,Poortvliet MC,Scheffer PG,Dekker JM,Ocke MC,Nijpels G,Stehouwer CD,Bouter LM,Teerlink T,Heine RJdoi
10.1038/sj.ejcn.1602492subject
Has Abstractpub_date
2007-02-01 00:00:00pages
205-11issue
2eissn
0954-3007issn
1476-5640pii
1602492journal_volume
61pub_type
杂志文章abstract:OBJECTIVE:We examined the relation between intake of natural dietary plant sterols and serum lipid concentrations in a free-living population. DESIGN, SETTING AND PARTICIPANTS:Cross-sectional population-based study of 22,256 men and women aged 39-79 y resident in Norfolk, UK, participating in the European Prospective ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601980
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Little is known about whether waist circumference (WC) has increased disproportionately relative to body mass index (BMI) around the world. SUBJECTS/METHODS:Data came from the US National Health and Nutrition Examination Survey (1988-1994 and 2007-2010), Health Survey for England (1992-1993 and 2...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.71
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.63
更新日期:2012-08-01 00:00:00
abstract::Efforts to combat nutrient deficiencies have centered on supplemental nutrient administration and addition of selected nutrients to the food chain in the form of food fortification. Over the past several decades, and as the association between diet and chronic diseases became apparent, supplementation and fortificatio...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1601803
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several factors affect the mental performance of children. The importance that parents attribute to food-related determinants, compared with genetic, socio-economic and school environment, was investigated. SUBJECTS/METHODS:Parents of school children (aged 4-11) were recruited through state prima...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.214
更新日期:2014-01-01 00:00:00
abstract::We examined satiety quotient (SQ) and energy intake (EI) according to sleep duration, quality and timing. Seventy-five overweight/obese men (age: 41.1±5.8 years; body mass index: 33.6±2.9 kg/m(2)) completed visual analogue scales for appetite sensations before, immediately after and every 10 minutes for 1 hour followi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.204
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600994
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:We examined the effects of a high fat diet rich in monounsaturated fat (MUFA-diet) and a moderate fat diet rich in polyunsaturated fat (PUFA-diet) on the susceptibility of LDL to oxidation. SUBJECTS:29 subjects with impaired glucose tolerance. METHODS:After consuming a run-in diet [37% of energy (E%) fat, ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600587
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Few published data are available on the feeding practice of younger children in Tibet. Our study investigated feeding pattern of younger Tibetan children. DESIGN AND SUBJECTS:The study was a cross-sectional survey conducted in Tibet. A sample of 1655 children younger than 36 months old and their mothers was ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602207
更新日期:2005-09-01 00:00:00
abstract::Successive determinations of serum total (T4) and free (FT4) thyroxine, total (T3) and free (FT3) 3,5,3'-triiodothyronine and total 3,3',5'-triiodothyronine (rT3) concentrations were performed by radioimmunoassay in 17 moderately obese women during a 6-week slimming cure. The 2.09 MJ/d (500 kcal/d) diet (50 per cent p...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::A World Health Organization (WHO) Expert Consultation on Waist Circumference (WC) and Waist-Hip Ratio (WHR) was convened in Geneva from 8 to 11 December 2008 to consider approaches to developing international guidelines for indices and action levels in order to characterize health risks associated with these measures ...
journal_title:European journal of clinical nutrition
pub_type:
doi:10.1038/ejcn.2009.139
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several diets, e.g., those low in fruits/vegetables, high in sodium, and red/processed meat, have been related to a higher stroke risk. We investigated stroke mortality associated with a priori diet-quality indices in the Multiethnic Cohort study. SUBJECTS/METHODS:Based on 172,043 observations in...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0103-4
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Flavanols may provide protection against insulin resistance, but little is known about the amounts and types of flavanols that may be efficacious. SUBJECTS/METHODS:This study was designed to determine whether cocoa flavanols, over a range of intakes, improve biomarkers of glucose regulation, infl...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/ejcn.2012.101
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the origin of the poor digestibility of banana starch granules in the human small intestine. DESIGN:The subjects received the same experimental meal. SETTING:Nutrition Research Unit, Laënnec Hospital, CHU, Nantes. SUBJECTS:Six healthy young subjects. INTERVENTIONS:The digestion of raw green b...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Adult skeletal muscle mass (SMM) protects against type 2 diabetes, but little is known about its developmental antecedents. We examined whether pace of early weight gain predicted adult SMM in a birth cohort from Cebu City, Philippines. In addition, we examined whether increases in SMM associated ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.18
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) with disability and frequency of relapses in relapsing-remitting multiple sclerosis (MS) patients. SUBJECTS/METHODS:The study included 184 patients with relapsing-remitting MS who were receiving immune-mo...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.51
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To describe the secular trends in the prevalence rates of iron-deficiency anemia (IDA) in infants in Israel, identify population group differences and assess the effectiveness of the 1985 Public Health directives on iron supplementation and avoidance of cow's milk in the first year of life. DESIGN:A systemat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601119
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To determine whether dairy fat in cheese raises low-density lipoprotein (LDL) cholesterol as much as in butter, since epidemiology suggests a different impact on cardiovascular disease. DESIGN:A randomised crossover trial testing the daily consumption of 40 g dairy fat as butter or as matured cheddar cheese,...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602211
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:The acute phase response (APR) influences indicators of iron status. A recent WHO/CDC consultation recommended concurrent measurement of alpha-1-acid-glycoprotein (AGP) in surveys to control for the APR, and aid in interpreting iron status. They proposed further exploratory analyses using AGP. We examined wh...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2008.33
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Health education and regulatory measures may contribute to lower population salt intake. Therefore, we aimed to describe knowledge and behaviors related to salt intake in Mozambique. SUBJECTS/METHODS:A cross-sectional evaluation of a representative sample of the population aged 15-64 years (n = 3...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0125-y
更新日期:2018-12-01 00:00:00
abstract::Cross-sectional data on growth outcome, upper-arm measurements and energy intake have been analysed according to the presence or absence of early feeding problems and poor appetite in 40 children (0.9-13 years) with congenital heart disease (CHD). At the time of study, refusal to eat or poor appetite was reported as a...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Bone marrow transplantation is often associated with multiple organ failure which is usually reversible. Oral mucositis and dysphagia, vomiting, diarrhoea, protein losing enteropathy, transient exocrine pancreatic impairment, hypoalbuminaemia, biochemical trace element and mineral deficiencies are all common following...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1600669
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:To study whether a free supply of vitamin D(2) drops to 6-week-old infants together with tailor-made information handouts improves the vitamin D status after 7 weeks in the intervention group compared to a control group. SUBJECTS/METHODS:In this cluster randomized controlled trial in eight child h...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602982
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Famine exposure is a potential risk factor for adverse cardiometabolic health. However, the relationship between famine exposure during early life and carotid plaque in adulthood remains unclear. Therefore, the aim was to investigate the relationship between famine exposure during early life and the risks fo...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-00756-7
更新日期:2020-09-16 00:00:00
abstract::The association of calcium intake with risk of developing hypertension in the general population has not been established yet. We systematically searched PubMed and Scopus databases up to February 2018 to find prospective observational studies investigating the association of calcium intake with risk of developing hyp...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:10.1038/s41430-018-0275-y
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To determine the effect of iron supplementation on iron status and endurance capacity. DESIGN:Randomized, double-blind iron supplementation. SETTING:University of Missouri-Columbia and surrounding community. SUBJECTS:Twenty iron-deficient (serum ferritin, sFer<16 microg/l; serum transferrin receptor, sTfR>...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602479
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN:A randomized, double blind, placebo-controlled clinical trial. SETTING:Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS:Twenty-five healthy elderly volun...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600938
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Improving dietary status is an important development objective, but monitoring of progress in this area can be too costly for many low-income countries. This paper demonstrates a simple, inexpensive technique for monitoring household diets in Mozambique. DESIGN:Secondary analysis of data from an intensive fi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601671
更新日期:2003-10-01 00:00:00
abstract::Urea kinetics was measured in a single woman on five occasions over four years by the prime/intermittent oral-dose method with [15N15N]-urea. On a nitrogen intake of 231 +/- 24 mg/kg/day, urea production was 198 +/- 22 mg/kg/day, with the urinary excretion of urea being 143 +/- 25 mg/kg/day. Urea hydrolysis and salvag...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Cross-sectionally, educational attainment is strongly associated with the prevalence of obesity, but this association is less clear for weight change during adult life. The objective of this study is to examine the association between educational attainment and weight change during adult life in t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.55
更新日期:2012-08-01 00:00:00