Abstract:
BACKGROUND:Vitamin D deficiency (VDD) affects the health and wellbeing of millions worldwide. In high latitude countries such as the United Kingdom (UK), severe complications disproportionally affect ethnic minority groups. OBJECTIVE:To develop a decision-analytic model to estimate the cost effectiveness of population strategies to prevent VDD. METHODS:An individual-level simulation model was used to compare: (I) wheat flour fortification; (II) supplementation of at-risk groups; and (III) combined flour fortification and supplementation; with (IV) a 'no additional intervention' scenario, reflecting the current Vitamin D policy in the UK. We simulated the whole population over 90 years. Data from national nutrition surveys were used to estimate the risk of deficiency under the alternative scenarios. Costs incurred by the health care sector, the government, local authorities, and the general public were considered. Results were expressed as total cost and effect of each strategy, and as the cost per 'prevented case of VDD' and the 'cost per Quality Adjusted Life Year (QALY)'. RESULTS:Wheat flour fortification was cost saving as its costs were more than offset by the cost savings from preventing VDD. The combination of supplementation and fortification was cost effective (£9.5 per QALY gained). The model estimated that wheat flour fortification alone would result in 25% fewer cases of VDD, while the combined strategy would reduce the number of cases by a further 8%. CONCLUSION:There is a strong economic case for fortifying wheat flour with Vitamin D, alone or in combination with targeted vitamin D3 supplementation.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Aguiar M,Andronis L,Pallan M,Högler W,Frew Edoi
10.1038/s41430-019-0486-xsubject
Has Abstractpub_date
2020-05-01 00:00:00pages
825-833issue
5eissn
0954-3007issn
1476-5640pii
10.1038/s41430-019-0486-xjournal_volume
74pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important sit...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.32
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To determine the effect of iron supplementation on iron status and endurance capacity. DESIGN:Randomized, double-blind iron supplementation. SETTING:University of Missouri-Columbia and surrounding community. SUBJECTS:Twenty iron-deficient (serum ferritin, sFer<16 microg/l; serum transferrin receptor, sTfR>...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602479
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS:A...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.173
更新日期:2012-12-01 00:00:00
abstract::To study the role of diet, 197 patients of essential hypertension were randomized to either experimental diet (group A, 97 cases) or normal diet (group B, 100 cases) with diuretics given to both the groups. The age varied between 25 and 65 years and 154 were males. The study diet included a significantly higher conten...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-04-01 00:00:00
abstract::Seven West African infants were studied prospectively from birth to 1 year to investigate factors affecting sleeping metabolic rate (SMR), particularly acute infection. There was no rise in SMR associated with acute infection, after adjustment for the effects of changes in body weight and body temperature. In the case...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the effects of fish oil supplementation in pregnancy on maternal erythrocyte fatty acid composition at different stages of pregnancy and in the post-partum period, and on neonatal erythrocyte fatty acid composition. DESIGN:A double-blind, randomised, placebo-controlled stu...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601825
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Living in socioeconomically disadvantaged neighbourhoods is associated with increased risk of a poor diet; however, the mechanisms underlying associations are not well understood. This study investigated whether selected healthy and unhealthy dietary behaviours are patterned by neighbourhood-socio...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.174
更新日期:2010-12-01 00:00:00
abstract::Ingested protein is made available to the body following digestion and absorption as amino acids and contributes to the body's demand for amino acids for protein synthesis and other metabolic pathways. As the pattern of amino acids required for metabolism is substantially different from that ingested, extensive metabo...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1600743
更新日期:1999-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:No prospective study on the long-term effects of gastric resection on gastrointestinal hormonal changes in patients with normal body weight has been reported. The aim of this study was to evaluate the 1-year effect of subtotal gastrectomy on ghrelin and peptide YY (PYY)(3-36) levels. SUBJECTS/MET...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.83
更新日期:2010-08-01 00:00:00
abstract::Green tea is commonly consumed in China, Japan, and Korea and certain parts of North Africa and is gaining popularity in other parts of the world. The aim of this review was to objectively evaluate the existing evidence related to green tea consumption and various health outcomes, especially cancer, cardiovascular dis...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/s41430-020-00710-7
更新日期:2020-08-20 00:00:00
abstract::A service evaluation of a pilot of a family-based behavioural management group programme for childhood obesity was conducted in a community setting in the United Kingdom. A total of 17 families with children aged 7.5-14 years completed the programme, which was delivered in 15 sessions over 6 months. Behavioural and ps...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.23
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To identify the types and quantities of 'extra' foods, or energy-dense, nutrient-poor foods, consumed by Australian adults, and assess their contribution to total energy and nutrient intakes. SUBJECT/METHODS:We used 24-h recall data from 10 851 adults, aged 19 years and over, who participated in the nationa...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2008.51
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. DESIGN:In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Dat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601909
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The risk factors for metabolic syndrome may differ between Western and Asian countries due to their distinct dietary cultures. However, few studies have directly compared macronutrient intake and its association with the risk of metabolic syndrome in the US and Korean adults using national survey ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-017-0031-8
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:Few published data are available on the feeding practice of younger children in Tibet. Our study investigated feeding pattern of younger Tibetan children. DESIGN AND SUBJECTS:The study was a cross-sectional survey conducted in Tibet. A sample of 1655 children younger than 36 months old and their mothers was ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602207
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diets rich in plant-based foods such as vegetables, fruits and soy foods have been suggested to have beneficial effects on health. However, phytochemicals contained in plant-based foods are generally bitter and acrid. We investigated whether intake of vegetables, fruits and soy foods is associated...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.127
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:This study aimed to examine the relationship between total pregnancy weight gain, maternal educational level, working status and infant birth weight among mothers and infants in urban health centers in Rasht, Iran. DESIGN:Pregnant women from six different public health centers in urban areas were studied in...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602239
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To determine the large intestinal endocrine cell types affected following dietary guidance in patients with irritable bowel syndrome (IBS). SUBJECTS/METHODS:The study included 13 IBS patients and 13 control subjects. The patients received three sessions of individualized dietary guidance. Both th...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.191
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The purpose of our study was to explore the relation of prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood in consecutive generations. SUBJECTS/METHODS:A total of 960 families, including 1920 parents (F1) who were born near the time of the Great Chinese famine...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0561-3
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:We aimed to validate the simplified nutrient profiling system (SENS) algorithm based on its ability to rank foods across the four SENS classes in relation to overall nutritional quality of both observed diets and nutritionally optimized diets. SUBJECTS/METHODS:Foods and beverages from the French ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0104-3
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. DESIGN:Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600648
更新日期:1998-11-01 00:00:00
abstract::The association of calcium intake with risk of developing hypertension in the general population has not been established yet. We systematically searched PubMed and Scopus databases up to February 2018 to find prospective observational studies investigating the association of calcium intake with risk of developing hyp...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:10.1038/s41430-018-0275-y
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies. SUBJECTS AND METHODS:Twenty-six women born between 1940 and 1950 were recruited ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602811
更新日期:2008-08-01 00:00:00
abstract::High serum antioxidant vitamins are increasingly being associated with reduced risk of coronary heart disease (CHD). Previous studies have not addressed the relationship between dietary antioxidant vitamins and risk of CHD although diet is a key factor which modifies blood antioxidant vitamin levels. In prospective st...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::The basal metabolic rate (BMR) was determined in 14 pairs of monozygotic (MZ; 11 females, 3 males) and 12 pairs of dizygotic (DZ; 10 females, 2 males) twins, with mean ages of 22.7 and 26 years. Zygosity was confirmed using DNA fingerprinting. When BMR was expressed as kJ/d, kJ/kg/d and kJ/kg FFM/d significant intra-c...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::This paper evaluates the safety for humans with regard to consumption of protein hydrolysates and fractions thereof, including bioactive peptides. The available literature on the safety of protein, protein hydrolysates, fractions thereof and free amino acids on relevant food legislation is reviewed and evaluated. A ne...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2009.56
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.63
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Observational studies have suggested low serum levels of vitamin B12 or folate to be risk factors of depression and anxiety. However, these results may be biased by confounding and reverse causation. Mendelian randomization studies are not subject to these limitations. The aim was to examine the a...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2017.97
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To measure body water distribution and to evaluate the accuracy of eight-polar bioelectrical impedance analysis (BIA) for the assessment of total body water (TBW) and extracellular water (ECW) in severe obesity. DESIGN:Cross-sectional study. SETTING:Obesity clinic. SUBJECTS:In all, 75 women aged 18-66 y, 2...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602049
更新日期:2005-02-01 00:00:00
abstract::Bioelectrical impedance analysis is an extremely popular method for assessment of body composition. Despite its wide-spread use over the past thirty years, its accuracy and clinical value is still questioned. Most frequently, criticisms focus on its purported poor absolute accuracy and that different impedance analyse...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/s41430-018-0335-3
更新日期:2019-02-01 00:00:00