当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL NUTRITION期刊下所有文献 > Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome.

Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome.

Abstract：

BACKGROUND/OBJECTIVES:To determine the large intestinal endocrine cell types affected following dietary guidance in patients with irritable bowel syndrome (IBS). SUBJECTS/METHODS:The study included 13 IBS patients and 13 control subjects. The patients received three sessions of individualized dietary guidance. Both the control subjects and the patients were scheduled for colonoscopies at baseline and again for the patients at 3-9 months after dietary guidance. Biopsy samples were taken from the colon and rectum and were immunostained for all types of large intestinal endocrine cells. The endocrine cells were quantified using computerized image analysis. RESULTS:The daily total consumption (mean±s.e.m. values) of fruits and vegetables rich in FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) decreased significantly from 16.2±5.3 g before receiving dietary guidance to 9.2±3.2 g after receiving dietary guidance (P=0.02). In the total colon, the densities of serotonin cells were 46.8±8.9, 10.5±2.1 and 22.6±3.2 cells/mm(2) in control subjects and in IBS patients before and after receiving dietary guidance, respectively (P=0.007); the corresponding densities of peptide YY cells were 11.6±1.8, 10.8±1.7 and 16.8±2.1 cells/mm(2), respectively (P=0.06). The cell densities for both serotonin and peptide YY did not change significantly in the rectum. The densities of somatostatin cells in the rectum were 13.5±3.0, 13.2±3.0, and 22.3±3.2 cells/mm(2) for control subjects and for IBS patients before and after receiving dietary guidance, respectively (P=0.01). CONCLUSIONS:The densities of the large intestinal endocrine cells tend to normalize following dietary guidance that may have contributed to the improvement of the patients with IBS symptoms.

journal_name

Eur J Clin Nutr

journal_title

European journal of clinical nutrition

authors

Mazzawi T,Hausken T,Gundersen D,El-Salhy M

doi

10.1038/ejcn.2015.191

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

175-81

issue

eissn

0954-3007

issn

1476-5640

pii

ejcn2015191

journal_volume

pub_type

杂志文章

在线工具

Dietary guidance normalizes large intestinal endocrine cell densities in patients with irritable bowel syndrome.