Abstract：
BACKGROUND/OBJECTIVES:To clarify the association of serum docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) levels with cognitive decline over 10 years. SUBJECTS/METHODS:This study was part of the National Institute for Longevity Sciences - Longitudinal Study of Aging, and was conducted with 232 male and 198 female Japanese community-dwelling subjects aged 60-79 years in the second wave (2000-2002). Cognitive function was assessed with the Mini-Mental State Examination (MMSE) in both the second and seventh (2010-2012) waves. Fasting venous blood samples were collected in the morning, and serum DHA and EPA levels were measured. Multiple logistic regression analysis was performed among participants with an MMSE score ≥ 24 in the second wave (n=430) to estimate the odds ratio (OR) and 95% confidence interval (CI) for MMSE score ≤ 23 or MMSE score decline ≥ 4 10 years later. These estimates were based on baseline tertiles of serum DHA or EPA levels, and controlled for age, sex, education, MMSE score at baseline, alcohol consumption, current smoking, body mass index and disease history. RESULTS:Fifteen (3.5%) subjects whose MMSE score was ≤ 23 and 36 (8.3%) subjects whose MMSE score declined to ≥ 4 showed cognitive decline. Multivariate-adjusted OR (95% CI) for the lowest through highest tertiles of serum DHA to MMSE score ≤ 23 or decline ≥ 4 were 1.00 (reference), 0.11 (0.02-0.58) and 0.17 (0.04-0.74), or 1.00 (reference), 0.22 (0.08-0.61) and 0.31 (0.12-0.75), respectively (P for trend=0.01 or 0.04). Serum EPA was not associated with cognitive decline. CONCLUSIONS:The study gives some indication that a moderately high level of serum DHA might prevent cognitive decline among community-dwelling elderly Japanese individuals.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Otsuka R,Tange C,Nishita Y,Kato Y,Imai T,Ando F,Shimokata Hdoi
10.1038/ejcn.2013.264subject
Has Abstractpub_date
2014-04-01 00:00:00pages
503-9issue
4eissn
0954-3007issn
1476-5640pii
ejcn2013264journal_volume
68pub_type
杂志文章abstract：BACKGROUND/OBJECTIVES:The risk factors for metabolic syndrome may differ between Western and Asian countries due to their distinct dietary cultures. However, few studies have directly compared macronutrient intake and its association with the risk of metabolic syndrome in the US and Korean adults using national survey ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-017-0031-8
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To assess the usefulness of fat-free mass (FFM) as an index of total body protein (TBPr) status in continuous ambulatory peritoneal dialysis (CAPD) patients. DESIGN:TBPr was measured by in vivo neutron activation analysis (IVNAA) and expressed as a standardised protein index (PI). FFM was estimated by dual e...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
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abstract：:Maintaining a good nutritional status is important for immune health and for managing metabolic comorbidities in adults with HIV infection. Little is known about the dietary habits of adults living with HIV infection in the United Kingdom. The aims of this study were to characterise their dietary intakes, and to ident...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.109
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:The aims of the study were: (i) to determine iodine status of schoolchildren living in northeast Italy; (ii) to assess dietary habits and iodine status and (iii) to investigate the level of knowledge concerning iodine sufficiency and ways to ameliorate iodine status. METHODS:One thousand three hundred seven...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.44
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abstract：:Glycaemic variability challenges the accuracy and use of the glycaemic index (GI). The purpose of the current study was to determine the role of mastication on GI. Using a randomized, controlled, crossover, non-blind design, 15 healthy young subjects returned on 5 separate days for three glucose and two rice test sess...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2013.231
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abstract：BACKGROUND/OBJECTIVES:Globally, fruit and vegetable intakes are well below recommendations despite ample evidence to link insufficient intake with increased risk of overweight and obesity. Intakes of fruits and vegetables in the general population differ between males and females, and although there is growing evidence...
journal_title：European journal of clinical nutrition
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abstract：BACKGROUND AND OBJECTIVE:Malnutrition is a common and underrecognized clinical problem among aged institutionalized patients. The aim of this study was to investigate how well nurses recognize malnutrition in elderly patients in long-term care hospitals in Helsinki. SUBJECTS AND METHODS:In this descriptive, cross-sect...
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pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602916
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abstract：OBJECTIVE:To study dietary lipid intake and plasma lipid profile of the Hong Kong Chinese population as part of a territory wide survey on cardiovascular risk factors. DESIGN:Randomised age and sex stratified survey. SUBJECTS:1010 subjects aged 25-74 y (500 men, 510 women). MEASUREMENTS:A food frequency method with ...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1600430
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602717
更新日期：2008-02-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602143
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1038/ejcn.2017.55
更新日期：2017-09-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600795
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2012.202
更新日期：2013-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41430-017-0070-1
更新日期：2018-11-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-0638-z
更新日期：2020-08-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:The importance of processing conditions, product thickness and effect of egg addition for the glycaemic and hormonal responses to pasta was studied. Healthy subjects were given test meals with an equivalent amount of available carbohydrate from extruded high-temperature dried spaghetti and three varieties of fresh rol...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600986
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doi：10.1038/sj.ejcn.1601342
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journal_title：European journal of clinical nutrition
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
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更新日期：2008-01-01 00:00:00
abstract：:In this issue we would like to thank all those listed below for taking the time to review for the European Journal of Clinical Nutrition in 2019-your generosity is much appreciated and we hope your association with the journal continues in the future. ...
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doi：10.1038/s41430-020-0589-4
更新日期：2020-03-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601651
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:The EURRECA (EURopean micronutrient RECommendations Aligned) Network of Excellence collated current micronutrient recommendations. A user-friendly tool, Nutri-RecQuest, was developed to allow access to the collated data and to create a database source for use in other nutritional software tools. METHODS:Rec...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.60
更新日期：2010-06-01 00:00:00
abstract：:Food composition tables were studied from nine European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC): Denmark, France, Germany, Greece, Great Britain, Italy, The Netherlands, Spain and Sweden. They were compared from the point view of availability, definition, anal...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600677
更新日期：1999-01-01 00:00:00
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journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.127
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To define the cellular basis for immune enhancement by a probiotic lactic acid bacteria strain (Bifidobacterium lactis HN019); and to determine whether immune enhancement can be optimized by delivery in oligosaccharide-enriched low-fat milk. DESIGN:A double-blind, three-stage before-and-after intervention tr...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601093
更新日期：2000-11-01 00:00:00
abstract：OBJECTIVE:This study examined the prevalence of obesity and hypertension and associated behavioral risk factors in adult men and women in Uzbekistan. The study also examined the association between obesity and hypertension. METHOD:The analysis used data from the 2002 Uzbekistan Health Examination Survey, which include...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602465
更新日期：2006-12-01 00:00:00
abstract：:It has been hypothesized that the increased risk of obesity among African Americans may be partially explained by low energy expenditure (EE) and impaired fat oxidation. Twelve White adults without obesity were pair-matched by age, sex and body mass index (BMI) to a sample of 12 African Americans. Resting EE (REE), 24...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0202-2
更新日期：2018-06-01 00:00:00
