Retrograded high-amylose corn starch reduces cholic acid excretion from the small bowel in ileostomy subjects.

Abstract:

OBJECTIVE:To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. DESIGN:Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of two test-products--drum-dried ordinary corn starch and autoclaved retrograded HACS, providing 5 and 39 g RS/d, respectively--was given, in random order. Ileostomy effluents were collected for 24 h per day and analysed for wet weight, dry weight, energy, bile acids and nutrients. SETTINGS:In-patient study at the metabolic ward, Department of Clinical Nutrition, Sahlgrenska University Hospital, Göteborg. RESULTS:Consumption of retrograded HACS caused (1) a 42% lower mean excretion of cholic acid (P = 0.024); (2) a 42% lower mean wet weight concentration of bile acids (P < 0.001); (3) a 70% increased excretion of dry weight (P = 0.001); and (4) a 41% increased excretion of energy (P= 0.036) compared with consumption of drum-dried ordinary corn starch. CONCLUSION:The reduced ileal excretion and concentration of cholic acid would be protective regarding colon cancer risk in addition to the increased fermentation substrate provided by RS and other energy-yielding components.

journal_name

Eur J Clin Nutr

authors

Langkilde AM,Ekwall H,Björck I,Asp NG,Andersson H

doi

10.1038/sj.ejcn.1600648

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

790-5

issue

11

eissn

0954-3007

issn

1476-5640

journal_volume

52

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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