Abstract：
BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was to ascertain whether serum FAs predicts the risk of incident AD and dementia in a longitudinal population-based cohort. SUBJECTS/METHODS:Uppsala Longitudinal Study of Adult Men started in 1970. The proportions of FAs in serum cholesteryl esters were estimated in men (n=2009) who were 50 years old at baseline. During a 35 year follow-up time, 213 men had developed dementia, out of which 91 AD. The associations were analyzed with Cox proportional hazards and logistic regression; adjusted for age, education and vascular risk factors. RESULTS:Subjects with a higher proportion of saturated FAs had a decreased risk of AD in crude and multi-adjusted models (hazard ratio for 1-s.d. increase in palmitic acid 0.72; 95% confidence intervals: 0.59-0.89). These associations persisted even in the group of approximately 85-year-old survivors. n-3 FAs FAs were not associated with decreased risk of AD or dementia. CONCLUSIONS:In contrast to experimental studies, saturated FAs were inversely associated with risk of AD. No evidence of a protective effect of n-3 FAs against dementia was found. The results remained essentially unchanged if competing risk from mortality was taken into account.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Rönnemaa E,Zethelius B,Vessby B,Lannfelt L,Byberg L,Kilander Ldoi
10.1038/ejcn.2012.63subject
Has Abstractpub_date
2012-08-01 00:00:00pages
885-90issue
8eissn
0954-3007issn
1476-5640pii
ejcn201263journal_volume
66pub_type
杂志文章abstract：OBJECTIVE:To study the variation in selenoprotein P levels in serum among healthy subjects from 17 European regions representing nine countries. SUBJECTS:Survey of 414 37-70-year-old subjects (197/217 males/females) from 17 regions. RESULTS:The level of selenoprotein P varied significantly among regions and countries...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The paper reviews the evidence to date on the nutritional links with productivity and then goes on to provide results from a multi-country study on the effects of increasing body mass index (BMI) on productivity. The research relating nutritional status to work capacity is more consistent than the research linking nut...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVE:To assess the effects of supplementation with the carotenoids, beta-carotene or lycopene, at levels achievable within a diet rich in fruit and vegetables, on immune function in a group of free-living healthy elderly. DESIGN:A double-blind randomized placebo-controlled trial. T cell subsets and the expression...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601187
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0212-0
更新日期：2019-03-01 00:00:00
abstract：:As type 2 diabetes mellitus (DM2), obesity and sedentary lifestyles are increasing in developing countries, this observational study investigated the role of physical activity on DM2 in Jamaica. Anthropometry, body composition (by bioelectrical impedance analysis) and glucose tolerance status was assessed in 722 adult...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602011
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Infancy may be a sensitive period regarding effects of sodium intake on future blood pressure (BP). This has only been demonstrated in one randomized trial of low sodium formulae with follow-up in adolescence in one-third of participants. OBJECTIVE:To prospectively assess associations between sodium intake ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602837
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:We have investigated the influence of vitamin C diet supplementation on the antioxidant response and nitrite levels in lymphocytes and erythrocytes during diving apnea. SUBJECTS:Seven male professional apnea divers participated in a double blind crossover study. Divers were randomly assigned to either vitami...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602388
更新日期：2006-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Disruptions in redox balance lead to oxidative stress, a promoter of morbidity in critical illness. This study aimed to: (1) characterize the plasma and alveolar thiol/disulfide redox pools, (2) examine their associations with alveolar macrophage phagocytosis, and (3) determine the effect of high ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41430-017-0047-0
更新日期：2018-05-01 00:00:00
abstract：:The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2010.240
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Fish intake and the long-chain omega-3 polyunsaturated fatty acids (PUFAs) in fish have been suggested to lower the risk of cognitive decline. We assessed whether serum long-chain omega-3 PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) are associated w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.59
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The elderly constitute a population group with a high prevalence of non-communicable chronic diseases and high risk of malnutrition. The aim of this study was to identify factors associated to nutritional risk in free-living European elderly. SUBJECTS/METHODS:The sample included 644 European citi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.175
更新日期：2013-11-01 00:00:00
abstract：:Administration of doses of linoleic acid (LA) up to 36 g/d in humans raised blood levels of linoleic acid but not of its metabolites. This is probably because the conversion of LA to gamma-linolenic acid (GLA) is slow and rate-limiting. We have found that administration of relatively small amounts of GLA, up to 360 mg...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVES:To determine the content of glutamine in major food proteins. SUBJECTS/METHODS:We used a validated 131-food item food frequency questionnaire (FFQ) to identify the foods that contributed the most to protein intake among 70,356 women in the Nurses' Health Study (NHS, 1984). The content of glutamine and other...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.110
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To validate bio-electric impedance spectroscopy (BIS) by comparison with other methods for determination of body water compartments in stable subjects with an ileostomy and no or minor small bowel resection for inflammatory bowel disease (IBD). SUBJECTS:Twenty-one subjects were included, age range 36-65 y (f...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601378
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. DESIGN:Randomized, diet-controlled, cross-over study. SETTING:The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. SUBJECTS:Ten middle-aged men and 10 postmen...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601459
更新日期：2002-11-01 00:00:00
abstract：:Serum lipid levels are considered to be one of the main risk factors for cardiovascular diseases in middle-aged men and women. The significance, however, of serum lipid metabolism as a cardiovascular disease risk factor in the elderly has yet to be clarified. This paper focuses upon the serum lipid levels of groups of...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：OBJECTIVE:This paper examines whether diet had changed at platforms in the Norwegian sector of the North Sea between 1985 and 1993 and if this was caused by nutrition promotive activities, including the use of a health handbook (HHB). DESIGN:The report is based on two cross-sectional surveys, one in 1985 and one in 19...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of biochemical iron deficiency and identify factors associated with ferritin levels among 6-24-month-old urban South Island New Zealand children. DESIGN:Cross-sectional survey conducted from May 1998 to March 1999. SETTING:The cities of Christchurch, Dunedin and Invercargill. S...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601751
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Urinary and plasma indices are utilized to assess whole-body water balance in healthy adults, whereas the urine-to-plasma osmolality ratio (Uosm:Posm) rarely is. To explore the efficacy of Uosm:Posm as a hydration biomarker, diet records of 120 college women were analyzed (beverage water+food wate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.79
更新日期：2013-09-01 00:00:00
abstract：:The refeeding syndrome is a potentially fatal condition that affects multiple organ systems. It is the consequence of fluid and electrolyte shifts that may occur in a malnourished patient following the introduction of nutrition therapy. The most prominent characteristic is hypophosphataemia. Although hyperammonaemia i...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.244
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:InBody-770 and SECA mBCA 515 are multifrequency bioelectrical impedance analysis (BIA) devices, which are commonly used in the clinic to assess fat-free mass (FFM) and body fat (BF). However, the accuracy between devices in clinical settings, across different body mass index (BMI) groups remains unclear. ME...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00839-5
更新日期：2021-01-22 00:00:00
abstract：OBJECTIVES:To determine the resting metabolic rate in a sample of the Italian population, and to evaluate the validity of predictive equations for resting metabolic rate (RMR) from the literature in normal and obese subjects. DESIGN:Cross-sectional observational study. SETTINGS:Department of Human Physiology and Nutr...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601149
更新日期：2001-03-01 00:00:00
abstract：OBJECTIVE:To describe the availability of food items at primary and secondary schools in Belgium-Flanders and to examine the influence of school food policy (availability of food items, school food rules, nutrition education programmes) and aggregated school socioeconomical status (AGG SES) on the consumption of fruit,...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602068
更新日期：2005-02-01 00:00:00
abstract：:We previously detected that ~50% of kidney transplant patients (KTPs) present sarcopenia using the first European Working Group on Sarcopenia in Older People (EWGSOP1) consensus. Our aim was to evaluate the agreement between the sarcopenia diagnosis using EWGSOP1 and the new consensus (EWGSOP2) in KTPs. A cross-sectio...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-019-0535-5
更新日期：2020-07-01 00:00:00
abstract：:Impaired β-cell function and insufficient β-cell mass compensation are twin pathogenic features that underlie type 2 diabetes (T2D). Current therapeutic strategies continue to evolve to improve treatment outcomes in different ethnic populations and include approaches to counter insulin resistance and improve β-cell fu...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2017.13
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To examine the influence of intense sweetener consumption on nutrient intakes in insulin dependent diabetics compared to controls. DESIGN:Case-control food consumption survey. SETTING:Dietary data were collected from individuals in Ireland between 1998 and 1999. SUBJECTS:Diabetics were recruited through di...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601969
更新日期：2004-10-01 00:00:00
abstract：OBJECTIVE:Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602398
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To investigate whether supplementation with vitamin A together with iron of Indonesian pregnant women decreases morbidity and improves growth of their infants during the first year of life. DESIGN:Women from a rural area in West Java, Indonesia, were randomly assigned on an individual basis to double-blind s...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601318
更新日期：2002-04-01 00:00:00
abstract：:Nutrition affects the brain throughout life, with profound implications for cognitive decline and dementia. These effects are mediated by changes in expression of multiple genes, and responses to nutrition are in turn affected by individual genetic variability. An important layer of regulation is provided by the epige...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2014.173
更新日期：2014-11-01 00:00:00
abstract：:The success of the Human Genome Project and the spectacular development of broad genomics tools have catalyzed a new era in both medicine and nutrition. The terms pharmacogenomics and nutrigenomics are relatively new. Both have grown out of their genetic forbears as large-scale genomics technologies have been develope...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1602590
更新日期：2007-05-01 00:00:00
