Abstract:
OBJECTIVES:To determine the content of glutamine in major food proteins. SUBJECTS/METHODS:We used a validated 131-food item food frequency questionnaire (FFQ) to identify the foods that contributed the most to protein intake among 70,356 women in the Nurses' Health Study (NHS, 1984). The content of glutamine and other amino acids in foods was calculated based on protein fractions generated from gene sequencing methods (Swiss Institute of Bioinformatics) and compared with data from conventional (USDA) and modified biochemical (Khun) methods. Pearson correlation coefficients were used to compare the participants' dietary intakes of amino acids by sequencing and USDA methods. RESULTS:The glutamine content varied from 0.01 to to 9.49 g/100 g of food and contributed from 1 to to 33% of total protein for all FFQ foods with protein. When comparing the sequencing and Kuhn's methods, the proportion of glutamine in meat was 4.8 vs 4.4%. Among NHS participants, mean glutamine intake was 6.84 (s.d.=2.19) g/day and correlation coefficients for amino acid between intakes assessed by sequencing and USDA methods ranged from 0.94 to 0.99 for absolute intake, -0.08 to 0.90 after adjusting for 100 g of protein, and 0.88 to 0.99 after adjusting for 1000 kcal. The between-person coefficient of variation of energy-adjusted intake of glutamine was 16%. CONCLUSIONS:These data suggest that (1) glutamine content can be estimated from gene sequencing methods and (2) there is a reasonably wide variation in energy-adjusted glutamine intake, allowing for exploration of glutamine consumption and disease.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Lenders CM,Liu S,Wilmore DW,Sampson L,Dougherty LW,Spiegelman D,Willett WCdoi
10.1038/ejcn.2009.110subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1433-9issue
12eissn
0954-3007issn
1476-5640pii
ejcn2009110journal_volume
63pub_type
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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doi:
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pub_type: 杂志文章,评审
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
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更新日期:2020-08-19 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2016-08-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:1999-06-01 00:00:00