Abstract：
OBJECTIVE:To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN:A randomized, double blind, placebo-controlled clinical trial. SETTING:Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS:Twenty-five healthy elderly volunteers (median age 69 y; range 60-83 y). INTERVENTIONS:Twelve control subjects consumed 180 ml low-fat/low-lactose milk twice daily for a period of 6 weeks; 13 test subjects consumed milk supplemented with 1.5x1011 colony-forming units of B. lactis twice daily. Indices of natural immunity, including interferon production, phagocytic capacity and phagocyte-mediated bactericidal activity, were determined via peripheral blood at 0, 3, 6 and 12 weeks post-trial commencement. RESULTS:Subjects who consumed milk containing B. lactis for 6 weeks produced significantly enhanced levels of interferon-alpha, upon stimulation of their peripheral blood mononuclear cells in culture, in comparison to the placebo control group who received milk alone. There were also significant increases in polymorphonuclear cell phagocytic capacity among test group subjects, following consumption of milk supplemented with B. lactis, while individuals who consumed B. lactis-supplemented milk or milk alone showed enhanced phagocyte-mediated bactericidal activity. CONCLUSIONS:The results demonstrate that dietary consumption of B. lactis HN019 can enhance natural immunity in healthy elderly subjects, and that a relatively short-term dietary regime (6 weeks) is sufficient to impart measurable improvements in immunity that may offer significant health benefits to consumers. SPONSORS:Financial support for this project was provided by the New Zealand Dairy Board.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Arunachalam K,Gill HS,Chandra RKdoi
10.1038/sj.ejcn.1600938subject
Has Abstractpub_date
2000-03-01 00:00:00pages
263-7issue
3eissn
0954-3007issn
1476-5640journal_volume
54pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:A constellation of reactive oxygen species (ROS) capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. The consequences of this leads to enhanced oxidative stress and lower antioxidant status. Enzymatic antioxidants provi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602221
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised polyunsaturated fatty acids such as alpha-linolenic acid with a diet rich in saturated fatty acids on the degree of lipid peroxidation in the human body. DESIGN:A randomised cross-over study. SUBJECTS A...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601246
更新日期：2001-11-01 00:00:00
abstract：:In this issue we would like to thank all those listed below for taking the time to review for the European Journal of Clinical Nutrition in 2019-your generosity is much appreciated and we hope your association with the journal continues in the future. ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-0589-4
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The cardiovascular benefit of increasing fruit and vegetable (F&V) intake following diagnosis of diabetes remains unknown. We aimed to describe how quantity and variety of F&V intake, and plasma vitamin C, change after diagnosis of type 2 diabetes and examine whether these changes are associated w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.180
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human volunteers. DESIGN:Double-blind, randomised, placebo-controlled intervention trial. SUBJECTS AND INTERVENTION:A total of 55 healthy volunteers (n=20 males, n=35 fe...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602132
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVES:To investigate side by side the effects on serum lipoproteins and postprandial glucose and insulin concentrations of beverages enriched with 5 or 10 g of beta-glucans from oats or barley. DESIGN AND SETTING:An 8-week single blind, controlled study with five parallel groups carried out at two centres under i...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602240
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies. SUBJECTS AND METHODS:Twenty-six women born between 1940 and 1950 were recruited ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602811
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:To assess the long-term effect of dietary advice on diet and mortality after a randomised trial of men with a recent history of myocardial infarction. DESIGN:Questionnaire survey and mortality follow-up after a trial of dietary advice. SETTING:Twenty-one hospitals in south Wales and south-west England. SUB...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601342
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Optimal obesity indices in predicting cardio-metabolic risk are less studied in Asian. We evaluated optimal waist-to-height ratio (WHtR) for predicting hypertension, dyslipidemia and diabetes in Han and Uygur populations in Xinjiang, a northwest part of China. SUBJECTS/METHODS:This study involved...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2015.25
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:The study was conducted to assess the relative validity of a 170-item semiquantitative food frequency questionnaire (SFFQ) adapted for use in the elderly. DESIGN AND SUBJECTS:The study was carried out in a sample of 80 men and women aged 55-75 y participating in a community based prospective cohort study in ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600611
更新日期：1998-08-01 00:00:00
abstract：:Insulin resistance is common and is determined by physiological (aging, physical fitness), pathological (obesity) and genetic factors. The metabolic compensatory response to insulin resistance is hyperinsulinaemia, the primary purpose of which is to maintain normal glucose tolerance. The 'carnivore connection' postula...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601351
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:It was determined whether a combination of Lactobacillus acidophilus (L. acidophilus) 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 (B. lactis 420) affect the faecal microbiota as well as immunological parameters and blood lipids in healthy adults. DESIGN:A placebo-controlled, double-blinded, rando...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602761
更新日期：2008-05-01 00:00:00
abstract：OBJECTIVE:Dietary counseling and intervention based on application of conventional criteria have been ineffective in preventing the progressive weight loss associated with HIV infection. The aim of the study was to compare the progression of clinical and nutritional indicators during nutritional supplementation with or...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601276
更新日期：2001-12-01 00:00:00
abstract：OBJECTIVE:To examine the effects of vitamin C supplementation on the concentration of oxidation markers, in particular, circulating oxidized LDL (OxLDL) and on endothelial activation markers. DESIGN:Randomized double-blind, placebo-controlled crossover trial. SETTING:Belgian population of the city of Leuven. SUBJECT...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601990
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Longitudinal studies investigating dietary patterns (DPs) and their association with childhood overweight/obesity are lacking in Europe. We identified DPs and investigated their association with overweight/obesity and changes in body mass index (BMI) in a cohort of European children. SUBJECTS/MET...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2013.145
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:Application of a HPLC (high performance liquid chromatography) method, using cyanide derivatisation, to the determination of plasma pyridoxal-5-phosphate (PLP) concentrations as an indicator of vitamin B6 adequacy. SETTING:The study was performed at the Institute of Food Research, Norwich, UK. Blood samples...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600775
更新日期：1999-06-01 00:00:00
abstract：:The success of the Human Genome Project and the spectacular development of broad genomics tools have catalyzed a new era in both medicine and nutrition. The terms pharmacogenomics and nutrigenomics are relatively new. Both have grown out of their genetic forbears as large-scale genomics technologies have been develope...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1602590
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To describe dietary carbohydrate intakes and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS:Between 1995 and 2000, 36 034 subjects, aged between 35-74 years, were administered a standardized, 24-h die...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.74
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To compare the efficacy of single versus multiple doses of plant sterols on circulating lipid level and cholesterol trafficking. SUBJECTS/METHODS:A randomized, placebo-controlled, three-phase (6 days/phase) crossover, supervised feeding trial was conducted in 19 subjects. Subjects were provided (...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2008.36
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:To estimate the intake of ruminant trans fatty acids (TFA) in the Danish population aged 1-80 years. DESIGN:Descriptive study. SUBJECTS:A sex- and age-stratified random sample drawn from the Danish Civil Registration System. A total of 3098 participants (51% female) aged 1-80 years were included. The partic...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602316
更新日期：2006-03-01 00:00:00
abstract：:The diet of many athletes is inadequate due to overly restrictive habits and an obsession with losing weight in order to maintain a particular level of body weight. Many female athletes, particularly those who participate in sports that emphasize leanness (gymnastics, distance running, diving, figure skating and class...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601483
更新日期：2002-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate two interventions (one reward-based and one exposure-based) for increasing children's acceptance of an unfamiliar vegetable compared with a no-treatment control. It was predicted that the exposure condition would increase liking for, and consumption of, the vegetable rela...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601541
更新日期：2003-02-01 00:00:00
abstract：:Both high and low vitamin D statuses have been associated with lower memory function. Apolipoprotein E (APOE) ɛ4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations. This report aims to examine if the presence of APOE ɛ4 alleles contributes to the relationship...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.201
更新日期：2015-04-01 00:00:00
abstract：:Energy density of foods, as opposed to their sugar or fat content, is said to be a key determinant of energy intakes. Recent laboratory studies have shown that, under ad lib conditions, subjects consume a constant weight or volume of food, so that their energy intakes depend on the energy density of the diet. Because ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600879
更新日期：1999-10-01 00:00:00
abstract：:This study was conducted to follow up healthy subjects from a previous study (Warwick & Williams, 1987) in which favourable dietary changes were achieved during 1 week immediately after dietary advice but were accompanied by reduced energy intakes and weight loss. Twenty-one subjects (8m, 13f; 57 per cent of the origi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVE:There are still controversies as to the potential beneficial effects of milk and fermented milk products on the level of lipoproteins. The objective of the present investigation was to test the effect of a moderate daily intake of a new fermented milk product, which was based on a bacterial culture obtained f...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. DESIGN:A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioecon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.99
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Hypertension affects about 30% of adults worldwide. Garlic has blood pressure-lowering properties and the mechanism of action is biologically plausible. Our trial assessed the effect, dose-response, tolerability and acceptability of different doses of aged garlic extract as an adjunct treatment to...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2012.178
更新日期：2013-01-01 00:00:00
abstract：:Ingested protein is made available to the body following digestion and absorption as amino acids and contributes to the body's demand for amino acids for protein synthesis and other metabolic pathways. As the pattern of amino acids required for metabolism is substantially different from that ingested, extensive metabo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600743
更新日期：1999-04-01 00:00:00
abstract：:Thirty-four healthy non-smoking subjects (20 men and 14 women) were given 25 ml cod liver oil (CLO) daily as dietary supplement for 8 weeks in a controlled cross-over study. Prior to intervention, women had significantly higher serum total (P < 0.05) and high density lipoprotein (HDL) (P < 0.001) cholesterol values, h...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-02-01 00:00:00
