Abstract:
BACKGROUND/OBJECTIVES:Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA). SUBJECTS/METHODS:Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used. Racial differences in total 25(OH)D trajectories (n = 343 women) were tested using an interaction term between blood draw gestational week and race in linear mixed-effects models. Linear regression and linear mixed-effects models estimated the adjusted associations between total 25(OH)D concentration with neonatal anthropometry and body composition (n = 252 with DXA) including interactions with infant sex and serum calcium. RESULTS:Total 25(OH)D concentration increased with gestational age, but its trajectory over pregnancy did not differ between African-American and Caucasian women. Deficient maternal vitamin D (25(OH)D concentration <20 ng/ml) was associated with lower neonatal total bone mineral density (β -0.009 g/cm2; 95% CI -0.016, -0.002). Among male newborns, deficiency was also associated with lower lean mass (-217 g; -391, -43) and birthweight (-308 g; -540, -76). Deficient maternal vitamin D was also associated with lower ponderal index (β -2.3 kg/m3; 95% CI -4.0, -0.5) among those in the lowest calcium tertile. CONCLUSION:Vitamin D deficiency during pregnancy is associated with lower bone density and smaller size at birth in certain subgroups suggesting its importance in fetal development.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Boghossian NS,Koo W,Liu A,Mumford SL,Tsai MY,Yeung EHdoi
10.1038/s41430-018-0212-0subject
Has Abstractpub_date
2019-03-01 00:00:00pages
424-431issue
3eissn
0954-3007issn
1476-5640pii
10.1038/s41430-018-0212-0journal_volume
73pub_type
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