Abstract:
BACKGROUND/OBJECTIVES:The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, which group fatty acids into naturally occurring patterns. We aimed to prospectively investigate associations between adipose tissue fatty acid patterns and long-term risk of total breast cancer and breast cancer subtypes characterised by oestrogen and progesterone receptor status (ER and PR). SUBJECTS/METHODS:This case-cohort study was based on data from the Danish cohort Diet, Cancer and Health. At baseline, a fat biopsy and information on lifestyle and reproductive factors were collected. From the 31 original fatty acids measured, patterns of fatty acids were identified using the treelet transform. During a median follow-up of 5.3 years, 474 breast cancer cases were identified. Hazard ratios and 95% confidence intervals of risk of total breast cancer and of subtypes according to quintiles of factor score were determined by weighted Cox proportional hazards regression. RESULTS:After adjustment for potential confounders, factor scores for the seven patterns identified by the treelet transform were not associated with risk of total breast cancer, nor with risk of ER+, ER-, PR+ or PR- tumours. CONCLUSIONS:No clear associations between the patterns of fatty acids at baseline and long-term risk of total breast cancer or ER+, ER-, PR+ or PR- tumours were observed.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Schmidt JA,Gorst-Rasmussen A,Nyström PW,Christensen JH,Schmidt EB,Dethlefsen C,Tjønneland A,Overvad K,Dahm CCdoi
10.1038/ejcn.2014.28subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1088-94issue
10eissn
0954-3007issn
1476-5640pii
ejcn201428journal_volume
68pub_type
杂志文章abstract:BACKGROUND/OBJECTIVES:It is not known if diets lower in greenhouse gas (GHG) emissions are also healthier. We evaluated the population health implications of changing to more sustainable diets in the UK, France, Finland, Italy and Sweden. SUBJECTS/METHODS:We developed a life table model to simulate mortality and morbi...
journal_title:European journal of clinical nutrition
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abstract::Dialysis patients are at increased risk for muscle wasting, and time efficient screening tests are required for to allow for early detection. Creatinine kinetics have been advocated to estimate lean body mass (LBM) in peritoneal dialysis (PD) patients, and can be readily calculated in clinical practice from peritoneal...
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doi:10.1038/s41430-017-0072-z
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abstract:OBJECTIVE:To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN:A randomized, double blind, placebo-controlled clinical trial. SETTING:Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS:Twenty-five healthy elderly volun...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600938
更新日期:2000-03-01 00:00:00
abstract::Aging is the major risk factor for the development of human neurodegenerative maladies such as Alzheimer's, Huntington's and Parkinson's diseases (PDs) and prion disorders, all of which stem from toxic protein aggregation. All of these diseases are correlated with cognitive decline. Cognitive Decline is a dynamic stat...
journal_title:European journal of clinical nutrition
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更新日期:2014-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2012.103
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To evaluate in 14 healthy volunteers the gastrointestinal tolerance to an indigestible bulking sweetener containing fructo-oligosaccharides (FOS). DESIGN:In order to mimic their usual pattern of consumption, FOS were ingested throughout the day either occasionally (once a week, first period) or regularly (ev...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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abstract:OBJECTIVE:To describe the perceptions of a healthy diet across Europe and to explore the socio-cultural factors that influence these perceptions. DESIGN:A cross-sectional study in which quota-controlled, nationally-representative samples of approximately 1000 adults from each country completed a face-to-face interview...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet can affect the acid-base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 chronic kidney diseas...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0689-1
更新日期:2020-08-01 00:00:00
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journal_title:European journal of clinical nutrition
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doi:10.1038/sj.ejcn.1600919
更新日期:2000-02-01 00:00:00
abstract::Two 8-h primed continuous infusions of L-[1-13C] leucine were used to determine fractional synthesis rates of albumin and non-albumin plasma protein in post-absorptive Type I diabetic patients during insulin infusion and its withdrawal. Fractional protein synthetic rates were calculated from the rate of incorporation ...
journal_title:European journal of clinical nutrition
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doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:The purpose of the present study was to compare the nutrient intake and the nutritional status between German middle-class alcohol consumers and non-drinkers. DESIGN:Cross-sectional study using patients with different stages of alcoholic liver disease (ALD) and healthy volunteers. SETTING:Southern Germany. ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601557
更新日期:2003-03-01 00:00:00
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journal_title:European journal of clinical nutrition
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doi:
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVE:To assess the long-term effect of dietary advice on diet and mortality after a randomised trial of men with a recent history of myocardial infarction. DESIGN:Questionnaire survey and mortality follow-up after a trial of dietary advice. SETTING:Twenty-one hospitals in south Wales and south-west England. SUB...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-06-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2005-05-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.21
更新日期:2011-06-01 00:00:00
abstract::The present study was conducted to test the efficacy of fibre supplementation for hypercholesterolaemia in subjects from the desert Nomads. Ten males (53 +/- 8 years of age) participated in this study which consisted of three phases: baseline-1 period (2 weeks) in which subjects were on their normal, habitual dietary ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::This study examined whether the association of household income with fresh fruit and vegetable consumption varies by the level of education. Data were derived from mail surveys carried out during 2000-2002 among 40- to 60-year-old employees of the City of Helsinki (n=8960, response rate 67%). Education was categorized...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.155
更新日期:2010-03-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
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doi:10.1038/sj.ejcn.1601260
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journal_title:European journal of clinical nutrition
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doi:10.1038/s41430-018-0212-0
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To assess the carotenoid status in young type I diabetic patients and its relationship to the glycaemic control of the disease. DESIGN:A follow-up study. SETTING:Hospital Universitario Puerta de Hierro, Health Area VI of Madrid (Spain). SUBJECTS:Forty-seven type I diabetic patients, followed for 2.5 years....
journal_title:European journal of clinical nutrition
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doi:10.1038/sj.ejcn.1602411
更新日期:2006-08-01 00:00:00
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更新日期:2018-03-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of dosage on the metabolic response to vegetables added to a mixed lunch meal, and to relate the amounts to the tripartite plate model. Carrots were chosen as an example, and the carrots were blanched, frozen and boiled to include possible effects of processing and cooking. The effects ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-06-01 00:00:00
abstract::Despite many methodological difficulties, studies evaluating the relationship between being small for gestational age (SGA) at birth and various measures of adverse neurologic outcome generally show significant associations. Nevertheless, cerebral palsy is rarely found in SGA infants. Minimal neurologic dysfunction is...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:The acute phase response (APR) influences indicators of iron status. A recent WHO/CDC consultation recommended concurrent measurement of alpha-1-acid-glycoprotein (AGP) in surveys to control for the APR, and aid in interpreting iron status. They proposed further exploratory analyses using AGP. We examined wh...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2008.33
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To describe the intake of vitamins thiamine (B1), riboflavin (B2), B6 (pyridoxine), B12 (cobalamine) and C (ascorbic acid) and their food sources among 27 centres in 10 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. METHODS:Between 1995 and 2000, 36...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.78
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602790
更新日期:2008-05-01 00:00:00