Abstract:
:Insulin resistance is a condition of gluco-metabolic sufferance that may hesitate in the further development of type 2 diabetes and cardiovascular disease. The development of insulin resistance is mostly associated with the accumulation of excessive fat in the body. The epidemic impact of obesity in the youngest promoted an increase of the prevalence of insulin resistance also in children and adolescents. Increased fat accumulation in the peri-visceral area of the abdomen, occurring preferably at and after puberty, and in the liver, as non-alcoholic fatty liver disease, plays a role in the process. After puberty, males are at higher risk than females to develop insulin resistance. Also ethnicity contributes to sensitivity of children to develop insulin resistance, where Hispanics, South-Asians, and Indians are at higher risk than Whites and Blacks.In spite of the research progress in the field, several questions on the relationship between body composition and insulin resistance are still unanswered. Multiomics approach, combined with nutrition as well as imaging techniques might contribute to unravel the role of body composition on insulin resistance.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Maffeis C,Morandi Adoi
10.1038/s41430-018-0239-2subject
Has Abstractpub_date
2018-09-01 00:00:00pages
1239-1245issue
9eissn
0954-3007issn
1476-5640pii
10.1038/s41430-018-0239-2journal_volume
72pub_type
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2013-09-01 00:00:00
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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journal_title:European journal of clinical nutrition
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doi:10.1038/sj.ejcn.1602845
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2010.76
更新日期:2010-08-01 00:00:00
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602553
更新日期:2007-04-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2011.98
更新日期:2011-09-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
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更新日期:1988-11-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2013-05-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1994-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00