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Moderate consumption of beer, red wine and spirits has counteracting effects on plasma antioxidants in middle-aged men.

Abstract：

OBJECTIVE:To evaluate the in vivo effects of moderate consumption of red wine, beer and spirits on antioxidants, antioxidant enzymes and antioxidant capacity. DESIGN:Randomized, diet-controlled, cross-over study. SUBJECTS:Twelve apparently healthy, non-smoking middle-aged men were included; 11 of them completed the study. INTERVENTIONS:Each subject consumed four glasses of red wine, beer, spirits and water (negative control) with evening dinner during four successive periods of 3 weeks, daily at the Institute. The total diet was supplied to the subjects and had essential the same composition during these 12 weeks. RESULTS:Neither the enzyme activities of serum glutathion peroxidase, erythrocyte glutathion reductase and superoxide dismutase nor the plasma concentrations of alpha- and gamma-tocopherol, lutein, zeaxantin, beta-cryptoxanthin, lycopene and alpha-carotene were affected. Plasma beta-carotene concentrations were decreased after 3 weeks' consumption of red wine, beer and spirits (40 g alcohol/day) as compared to consumption of water, by 15% (P=0.0005), 11% (P=0.010) and 13% (P=0.003), respectively. Also, plasma ascorbic acid was decreased after beer (15%, P=0.004) and spirits (12%, P=0.030), but not after wine consumption. Serum uric acid concentrations were increased after consumption of beer (15%, P<0.0001), spirits (8%, P=0.008) and red wine (9%, P=0.003). The overall serum antioxidant capacity, assessed as Trolox equivalent antioxidant capacity (TEAC), was similar for all treatments. CONCLUSIONS:Moderate consumption of red wine, beer and spirits has counteracting effects on plasma antioxidant components, resulting in no significant effect on overall antioxidant status. The effects on antioxidant parameters are largely independent of the type of alcoholic beverage, and probably irrelevant to chronic disease risk. SPONSORSHIP:Dutch Foundation for Alcohol Research (SAR).

journal_name

Eur J Clin Nutr

journal_title

European journal of clinical nutrition

authors

van der Gaag MS,van den Berg R,van den Berg H,Schaafsma G,Hendriks HF

doi

10.1038/sj.ejcn.1601061

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

586-91

issue

eissn

0954-3007

issn

1476-5640

journal_volume

pub_type

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Moderate consumption of beer, red wine and spirits has counteracting effects on plasma antioxidants in middle-aged men.