Abstract：
OBJECTIVE:To investigate the relationship between the common cold and vitamin C supplementation. DESIGN:A double-blind, 5-year randomized controlled trial. SETTING:A village in Akita prefecture, one of the regions in Japan with the highest mortality from gastric cancer. SUBJECTS:Participants in annual screening programs for circulatory diseases conducted under the National Health and Welfare Services Law for the Aged, and diagnosed as having atrophic gastritis. Of the 439 eligible subjects, 144 and 161 were assigned to receive 50 or 500 mg of vitamin C, respectively, after protocol amendment. During the supplementation phase, 61 dropped out, and 244 completed the trial. INTERVENTION:Daily vitamin C supplementation of 50 mg (low-dose group) or 500 mg (high-dose group). RESULTS:Total number of common colds (per 1000 person-months) was 21.3 and 17.1 for the low- and high-dose groups, respectively. After adjustment for several factors, the relative risks (95% confidence interval (CI)) of suffering from a common cold three or more times during the survey period was 0.34 (0.12-0.97) for the high-dose group. No apparent reduction was seen for the severity and duration of the common cold. CONCLUSION:A randomized, controlled 5-year trial suggests that vitamin C supplementation significantly reduces the frequency of the common cold but had no apparent effect on the duration or severity of the common cold. However, considering several limitations due to protocol amendment, the findings should be interpreted with caution.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Sasazuki S,Sasaki S,Tsubono Y,Okubo S,Hayashi M,Tsugane Sdoi
10.1038/sj.ejcn.1602261subject
Has Abstractpub_date
2006-01-01 00:00:00pages
9-17issue
1eissn
0954-3007issn
1476-5640pii
1602261journal_volume
60pub_type
杂志文章,随机对照试验abstract：BACKGROUND/OBJECTIVES:Longitudinal studies investigating dietary patterns (DPs) and their association with childhood overweight/obesity are lacking in Europe. We identified DPs and investigated their association with overweight/obesity and changes in body mass index (BMI) in a cohort of European children. SUBJECTS/MET...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2013.145
更新日期：2013-10-01 00:00:00
abstract：:The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：OBJECTIVE:To examine the effects of vitamin C supplementation on the concentration of oxidation markers, in particular, circulating oxidized LDL (OxLDL) and on endothelial activation markers. DESIGN:Randomized double-blind, placebo-controlled crossover trial. SETTING:Belgian population of the city of Leuven. SUBJECT...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601990
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602790
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency (VDD) affects the health and wellbeing of millions worldwide. In high latitude countries such as the United Kingdom (UK), severe complications disproportionally affect ethnic minority groups. OBJECTIVE:To develop a decision-analytic model to estimate the cost effectiveness of population...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-019-0486-x
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Present study aims to longitudinally explore independent association of physical activity and sedentary behaviors with body weight. SUBJECTS/METHODS:This study included 15050 adults who have complete demographic and dietary data, leisure time physical activity (LTPA) and sedentary behavior evalua...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.262
更新日期：2017-03-01 00:00:00
abstract：:A cross-sectional study of 58 infants (age range 2-53 weeks) was carried out in a rural area of northern Thailand. Total dietary intake (energy and protein from breastmilk and supplementary food) was measured directly during continuous observation over 48 h of randomly selected study subjects in their homes. Associati...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Current lifestyles and the choice and availability of foods may influence the eating patterns of children. The aim of this study was to investigate the meal and snacking patterns of school-aged children in Scotland. METHODS:A sub-sample of 156 children (5-17 years) from the national Survey of Sugar Intake a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.87
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To assess the usefulness of fat-free mass (FFM) as an index of total body protein (TBPr) status in continuous ambulatory peritoneal dialysis (CAPD) patients. DESIGN:TBPr was measured by in vivo neutron activation analysis (IVNAA) and expressed as a standardised protein index (PI). FFM was estimated by dual e...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The purpose of this paper is to assess the food habits of the Spanish population and the composition of the fat consumed. The national food survey data have been used. This survey was carried out during one week in a representative sample of households by means of recorded weighing or the household measures method. Th...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The fundamental principles of energy physiology were used to evaluate the validity of reported energy intake (EI) in 37 published dietary studies of adults providing 68 subgroups when classified according to sex and dietary method. EI was expressed as a multiple of BMR estimated using the reported heights and weights ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Low birth weight (LBW), defined as the body weight at birth of less than 2500 g, is a major public health problem in Bangladesh, where 37% of the babies are born with LBW. The objective of this study is to see the impact of nutrition education on growth of LBW babies with early initiation and excl...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2011.182
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:To investigate the possible differential role of refined and whole grain cereals on the risk of upper digestive and respiratory tract neoplasms. DESIGN:Hospital-based case-control study. SETTING:University Hospital of Lausanne, Switzerland. SUBJECTS:A total of 156 incident cases of cancers of the oral cavi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601043
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Fiber-rich diets have been proposed to lower circulating levels of inflammatory makers. Our objective was to investigate cross-sectional relationships between fiber intake and plasma fibrinogen. SUBJECTS/METHODS:We examined the relationship between plasma fibrinogen and dietary fiber in 20,960 me...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.194
更新日期：2012-04-01 00:00:00
abstract：OBJECTIVE:To identify if the nutritional status and improvements in Vietnam during the 1990s applied equally to the key vulnerable population groups (poor, rural, and ethnic minority) as it did to the nonpoor-largely in the urban areas. DESIGN:This study used cross-sectional analyses in the context of inequalities occ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601761
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Food labels may have an important function in communicating nutrition information and have considerable potential to influence food choice and dietary behaviour. OBJECTIVES:To assess the validity and reliability of a short (self-complete) questionnaire designed to measure consumers' use and understanding of...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.126
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:The aims of the study were: (i) to determine iodine status of schoolchildren living in northeast Italy; (ii) to assess dietary habits and iodine status and (iii) to investigate the level of knowledge concerning iodine sufficiency and ways to ameliorate iodine status. METHODS:One thousand three hundred seven...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.44
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Several factors affect the mental performance of children. The importance that parents attribute to food-related determinants, compared with genetic, socio-economic and school environment, was investigated. SUBJECTS/METHODS:Parents of school children (aged 4-11) were recruited through state prima...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.214
更新日期：2014-01-01 00:00:00
abstract：:Alcohol-induced hypoglycaemia is a well-known phenomenon in insulin-treated diabetic subjects. Less attention has been paid to the impact of alcohol on blood glucose and insulin responses in non-insulin dependent diabetic subjects. The aim of this study was to investigate the acute metabolic effects of different alcoh...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:This study examined the prevalence of obesity and hypertension and associated behavioral risk factors in adult men and women in Uzbekistan. The study also examined the association between obesity and hypertension. METHOD:The analysis used data from the 2002 Uzbekistan Health Examination Survey, which include...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602465
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVES:A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. DESIGN:A prospective...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602412
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVE:To calculate intra-cluster and intra-household design effects and intra-class correlation coefficients for dietary nutrients obtained from a 24 h record-assisted recall. DESIGN:Children were recruited using clustered probability sampling. Randomly selected starting-point addresses were obtained with probabil...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602618
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to analyse the intake of coeliac disease (CD) inducing, gluten containing cereals (wheat, rye, barley and oats) in Estonian infants diet and compare these results with neighbouring countries with different CD incidence rate. DESIGN:Study group consisted of 32 healthy full term infan...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600511
更新日期：1998-02-01 00:00:00
abstract：OBJECTIVE:To study the effect of meal composition on pancreatic polypeptide release during modified sham feeding. DESIGN:In random order and on separate occasions, isocaloric, isothermic, isoosmotic, homogenized meals (1050 kJ; 250 kcal) either rich in fat (walnuts; 64 g fat, 7 g protein, 15 g starch per 100 g), prote...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:To ascertain whether body mass index (BMI) cutoffs calculated according to age and pubertal stage are superior to BMI cutoffs calculated on the basis of age alone at correctly identifying children and adolescents with high levels of adiposity. DESIGN:Cross-sectional study. SETTING:Dunedin, a university city...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601608
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVE:These two studies compared the subjective assessment of how filling a snack type would be, with actual consumption of that type of snack at a snack meal. DESIGN:Four snack types: savory high-fat, savory high-carbohydrate, sweet high-carbohydrate, each comprising of five food items, were used. Study 1 consist...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:There is increasing evidence to support that a high-protein diet may promote weight loss and prevent weight (re)gain better than a low-protein diet, and that the effect is due to higher diet-induced thermogenesis (DIT) and increased satiety. However, data on the effect of different types of protei...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2011.221
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The term 'beer belly' expresses the common belief that beer consumption is a major determinant of waist circumference (WC). We studied the gender-specific associations between beer consumption and WC (partially in relation to body weight and hip circumference (HC) change). PARTICIPANTS/METHODS:Wi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.39
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the role of the C677T-MTHFR (methylenetetrahydrofolate reductase)-polymorphism (CC, CT and TT) for vascular complications in liver transplant recipients. DESIGN:Retrospective study. SETTING:Hepatology-Transplantation-Unit, Johann Wolfgang Goethe-University, Frankfurt am...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602699
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Fall accidents may reduce an individual's quality of life and ability to perform the activities of daily life, and may delay recovery from illness. Consequently, medical institutions need to take measures to prevent falls. There are various risk factors for falls, including advanced age, illness a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.195
更新日期：2015-02-01 00:00:00
