Abstract:
INTRODUCTION:In the UK, colorectal cancer is the fourth most common cancer and the second most common cause of cancer death. Surgery is the primary modality of treatment, but it is not without complications. Post-operative complications have been linked to preoperative of weight loss and loss of lean tissue, and also to obesity. Given sex differences in body composition, an examination of body composition and post-operative complications may provide valuable information. Therefore, the aim was to examine the relationship between male/female body composition and post-operative complications in patients with operable colorectal cancer. METHODS:Patients (n = 741) undergoing operation for colorectal cancer were examined. Preoperative CT scans were used to define the muscle mass and quality, visceral obesity, and subcutaneous adiposity. Post-operative complications, in particular, surgical site infection (SSI) and wound infection (WI) were considered as outcome measures. RESULTS:Male patients with greater subcutaneous adiposity had higher risk of SSI and WI (p < 0.01 and p ≤ 0.001, respectively). On multivariate analysis, Post-operative Glasgow Prognostic Score (poGPS) on Day 4 (OR 2.11, 95% CI 1.53-2.92, P = 0.001) laparoscopic surgery (OR 0.50, 95% CI 0.26-0.98, P = 0.044), and subcutaneous adiposity (OR 2.71, 95% CI 1.26-5.82, P = 0.011) remained significantly independently associated with overall SSI. Subcutaneous adiposity remained significantly independently associated with WI (OR 3.93, 95% CI 1.33-11.57, P = 0.013). In female patients, however, no significant association was found between any body composition measure and complications. CONCLUSION:This study showed that increased subcutaneous and visceral adiposity were associated with infective complications in male, but not female patients, after colorectal cancer surgery. Therefore, it is important that sex be taken into account when evaluating the potential impact of body composition on post-operative outcomes in patients undergoing surgery for colorectal cancer.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Almasaudi AS,Dolan RD,McSorley ST,Horgan PG,Edwards C,McMillan DCdoi
10.1038/s41430-019-0414-0subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1450-1457issue
11eissn
0954-3007issn
1476-5640pii
10.1038/s41430-019-0414-0journal_volume
73pub_type
杂志文章abstract:BACKGROUND:It is hypothesised that epigenetic mechanisms including DNA methylation may underlie the relationship between early-life nutrition and child cognitive outcomes. This study aimed to identify dietary patterns associated with the intake of one-carbon metabolism nutrients in children aged 2-3 years. METHODS:A v...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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abstract:OBJECTIVE:To assess the bioavailability of vitamins A and E administered parenterally with either water-soluble or lipid-soluble preparations. STUDY DESIGN:A water soluble preparation (MVI Pediatric) administered with a glucose-amino acid solution and a lipid soluble preparation (Vitalipid N Infant) infused with a lip...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To determine the origin of the poor digestibility of banana starch granules in the human small intestine. DESIGN:The subjects received the same experimental meal. SETTING:Nutrition Research Unit, Laënnec Hospital, CHU, Nantes. SUBJECTS:Six healthy young subjects. INTERVENTIONS:The digestion of raw green b...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:The content of n-3 (omega-3) polyunsaturated fatty acids in fat tissue is a valid indicator of their long-term consumption. We studied the stability of n-3 fatty acids in human subcutaneous fat microbiopsies after 6 and 11 y of storage. DESIGN:Microbiopsies were taken from a lump of human adipose tissue and...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601614
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the ability of designer eggs enriched in vitamin E, lutein, selenium (Se) and docosahexaenoic acid (DHA) to deliver micronutrients to the human in a palatable and visually acceptable form. DESIGN:Double-blind, placebo-controlled trial, two treatment groups balanced for sex and age. SETTING:Depar...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600939
更新日期:2000-04-01 00:00:00
abstract::A cross-sectional study of 58 infants (age range 2-53 weeks) was carried out in a rural area of northern Thailand. Total dietary intake (energy and protein from breastmilk and supplementary food) was measured directly during continuous observation over 48 h of randomly selected study subjects in their homes. Associati...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:We aimed to validate the simplified nutrient profiling system (SENS) algorithm based on its ability to rank foods across the four SENS classes in relation to overall nutritional quality of both observed diets and nutritionally optimized diets. SUBJECTS/METHODS:Foods and beverages from the French ...
journal_title:European journal of clinical nutrition
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doi:10.1038/s41430-018-0104-3
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Growth parameters during infancy and early childhood might predict adipokine levels later in life. This study investigates the association between peak growth velocities, body mass index (BMI) and age at adiposity rebound (AR), with leptin and adiponectin levels at age 10 years. SUBJECTS/METHODS:...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2013.213
更新日期:2014-01-01 00:00:00
abstract::While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body's long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, howeve...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2016.256
更新日期:2017-03-01 00:00:00
abstract::Cross-sectional data on growth outcome, upper-arm measurements and energy intake have been analysed according to the presence or absence of early feeding problems and poor appetite in 40 children (0.9-13 years) with congenital heart disease (CHD). At the time of study, refusal to eat or poor appetite was reported as a...
journal_title:European journal of clinical nutrition
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doi:
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The aims were to investigate the association of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with breastfeeding (BF) duration and BF pattern at 3 months of age. SUBJECTS/METHODS:This was a prospective cohort study of 4231 children who were enrolled at birth and w...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2015.232
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The study was designed to evaluate the vitamin D status in women of different physiological status of two socio-economic groups in Bangladesh. DESIGN:A cross-sectional study, using serum 25-hydroxyvitamin D (25-OHD), calcium, phosphorus and alkaline phosphatase activity. SETTING:Two regions of Bangladesh. T...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601284
更新日期:2002-01-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600775
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS:Case-control study. Cases were 555 women (mean age 31 years, range 16-43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The contro...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602419
更新日期:2006-09-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602211
更新日期:2005-09-01 00:00:00
abstract::The fundamental principles of energy physiology were used to evaluate the validity of reported energy intake (EI) in 37 published dietary studies of adults providing 68 subgroups when classified according to sex and dietary method. EI was expressed as a multiple of BMR estimated using the reported heights and weights ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00
abstract:OBJECTIVE:To investigate the association between total alcohol intake and intake of different types of alcoholic beverages in relation to the risk of basal cell (BCC) and squamous cell (SCC) carcinoma of the skin. DESIGN:Prospective cohort study. SETTING:Follow-up data from a community-based skin cancer study in Aust...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602717
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between selenium nutritional status and intermediates of human immunodeficiency virus (HIV)-1 transmission. DESIGN:Prospective cohort study. SETTING:A study clinic at Muhimbili National Hospital, Dar es Salaam, Tanzania. SUBJECTS:A total of 340 HIV-1-infected pregnant women with...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602567
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.20
更新日期:2016-09-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602669
更新日期:2007-09-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.127
更新日期:2012-01-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2016-08-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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abstract:BACKGROUND/OBJECTIVES:There have been few studies on the association of fruit and vegetable (FV) intake with cardiovascular disease (CVD) risk in Asian populations where both dietary habits and disease structure are different from western countries. No study in Asia has found its significant association with stroke. We...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.276
更新日期:2015-04-01 00:00:00
abstract::Pregnancy and the first two years of life are periods of rapid growth and yet the knowledge of requirements for protein and dietary indispensable amino acids is very limited. The development of carbon oxidation methods opens the way to studies that should fill these important gaps in knowledge. ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.297
更新日期:2014-03-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602636
更新日期:2007-10-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
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更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The EFCOSUM (European Food Consumption Survey Methods) Project aims at harmonizing food consumption surveys in European countries within the perspective of an overall Public Health Monitoring Programme. Harmonization implies the need for a common framework of procedures and tools, that are applicable and fea...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601431
更新日期:2002-05-01 00:00:00
abstract::The pharmacokinetics of vitamin C following a 500 mg oral tablet dose were compared in a group of fourteen healthy young women whose age was 26.0 +/- 2.8 years (mean +/- s.d.), and in a group of fourteen healthy elderly women aged 68.1 +/- 2.6 years. The body composition of each subject was assessed using several anth...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00