Abstract：
OBJECTIVE:To test the effect of supplementation of diet with ascorbic acid, selenium, alpha-tocopherol and beta-carotene on the oxidation resistance of very low (VLDL) + low density lipoprotein (LDL). DESIGN:A randomized placebo-controlled double-masked clinical trial. SETTING:In healthy men aged 30-58 years smoking regularly 15-40 cigarettes/day. SUBJECTS:Forty subjects recruited from the general population, who all completed the study. INTERVENTION:400 mg of slow release ascorbic acid, 100 micrograms of organic selenium, 200 mg of D-alpha-tocopheryl acetate and 30 mg of beta-carotene daily or placebo, 20 men in each group for 3 months. MAIN OUTCOME MEASURES:The oxidation resistance of VLDL + LDL measured by inducing oxidation with copper chloride and, separately, with a combination of haemin and H2O2. RESULTS:In plasma, alpha-tocopherol increased by 72%, beta-carotene by 209%, ascorbate by 45% and selenium by 20% in the supplemented men. The lag time to oxidation increased by 27% [95% confidence interval (CI) 18-35%, P < 0.001] after copper and by 29% (95% CI 12-46%, P = 0.002) after haemin plus H2O2 in the supplemented group as compared to the placebo group by t-tests. The respective net changes in the maximal oxidation velocity were a reduction of 10% (95% CI 1-21%, P = 0.037) after copper and a reduction of 15% (95% CI-1 to 30%, P = 0.070) after haemin and H2O2. CONCLUSIONS:These findings provide further confirmation for the notion that the supplementation of diet with antioxidative vitamins and selenium increases the oxidation resistance of atherogenic lipoproteins in human plasma.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Nyyssönen K,Porkkala E,Salonen R,Korpela H,Salonen JTsubject
Has Abstractpub_date
1994-09-01 00:00:00pages
633-42issue
9eissn
0954-3007issn
1476-5640journal_volume
48pub_type
临床试验,杂志文章,随机对照试验abstract：:Green tea is commonly consumed in China, Japan, and Korea and certain parts of North Africa and is gaining popularity in other parts of the world. The aim of this review was to objectively evaluate the existing evidence related to green tea consumption and various health outcomes, especially cancer, cardiovascular dis...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/s41430-020-00710-7
更新日期：2020-08-20 00:00:00
abstract：BACKGROUND/OBJECTIVES:Several diets, e.g., those low in fruits/vegetables, high in sodium, and red/processed meat, have been related to a higher stroke risk. We investigated stroke mortality associated with a priori diet-quality indices in the Multiethnic Cohort study. SUBJECTS/METHODS:Based on 172,043 observations in...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0103-4
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:In spite of several studies relating dietary patterns to breast cancer risk, evidence so far remains inconsistent. This study aimed to investigate associations of dietary patterns derived with three different methods with breast cancer risk. SUBJECTS/METHODS:The Mediterranean Diet Score (MDS), pr...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2014.135
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of dosage on the metabolic response to vegetables added to a mixed lunch meal, and to relate the amounts to the tripartite plate model. Carrots were chosen as an example, and the carrots were blanched, frozen and boiled to include possible effects of processing and cooking. The effects ...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVE:To study the effect of meal composition on pancreatic polypeptide release during modified sham feeding. DESIGN:In random order and on separate occasions, isocaloric, isothermic, isoosmotic, homogenized meals (1050 kJ; 250 kcal) either rich in fat (walnuts; 64 g fat, 7 g protein, 15 g starch per 100 g), prote...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-08-01 00:00:00
abstract：:To study the role of diet, 197 patients of essential hypertension were randomized to either experimental diet (group A, 97 cases) or normal diet (group B, 100 cases) with diuretics given to both the groups. The age varied between 25 and 65 years and 154 were males. The study diet included a significantly higher conten...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-04-01 00:00:00
abstract：BACKGROUND:Mediterranean diets are felt to be healthful diets linked with reduced mortality from diet-related noncommunicable diseases. OBJECTIVE:To examine trends in diet, activity, obesity and diet-related noncommunicable diseases for Spain and compare these with other European countries, particularly those from the...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601414
更新日期：2002-10-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence of low body weight in Beijing pubertal girls and to establish the cut-off for body mass index (BMI) for underweight for Chinese pubertal girls. DESIGN:Cross-sectional study. SETTING:Three socioeconomic areas (rural, suburban and urban) in Beijing, China. SUBJECTS:Random sample...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601599
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:A possible role for vitamin D deficiency in contributing to the winter increase in cardiovascular disease mortality was investigated by testing the effect of vitamin D supplementation on blood pressure and other cardiovascular risk factors during winter. DESIGN:Randomised double-blind trial of vitamin D supp...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:Older people are becoming an increasingly important proportion of the populations of developing countries, yet little information exists on their nutritional status or social conditions. OBJECTIVE:To assess the nutritional status of older people in rural Malawi. DESIGN:Cross-sectional study. SETTING:Lilon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600617
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:To validate bio-electric impedance spectroscopy (BIS) by comparison with other methods for determination of body water compartments in stable subjects with an ileostomy and no or minor small bowel resection for inflammatory bowel disease (IBD). SUBJECTS:Twenty-one subjects were included, age range 36-65 y (f...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601378
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600994
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:To determine whether diet supplementation with arabinoxylan-rich (AX)-fibre from wheat improves glycaemic control in Type II diabetes. DESIGN:Randomized, crossover intervention trial. SETTING:Monash Medical Centre. SUBJECTS:A total of 15 subjects with Type II diabetes. INTERVENTIONS:Over two 5-week period...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601857
更新日期：2004-04-01 00:00:00
abstract：:Bioelectrical impedance analysis is an extremely popular method for assessment of body composition. Despite its wide-spread use over the past thirty years, its accuracy and clinical value is still questioned. Most frequently, criticisms focus on its purported poor absolute accuracy and that different impedance analyse...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/s41430-018-0335-3
更新日期：2019-02-01 00:00:00
abstract：:Traditional methods for estimating total body fat rely on the assumption that body fat distribution and bone mineral content are constant. However, in patients undergoing renal transplantation rapid changes in body composition occur, with variations in fat distribution and bone mineral content. In order to determine t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:The purpose of this paper is to assess the food habits of the Spanish population and the composition of the fat consumed. The national food survey data have been used. This survey was carried out during one week in a representative sample of households by means of recorded weighing or the household measures method. Th...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVE:The study was conducted to assess the relative validity of a 170-item semiquantitative food frequency questionnaire (SFFQ) adapted for use in the elderly. DESIGN AND SUBJECTS:The study was carried out in a sample of 80 men and women aged 55-75 y participating in a community based prospective cohort study in ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600611
更新日期：1998-08-01 00:00:00
abstract：:Nuclear receptors for retinoids were discovered in 1987 and appeared to belong to the superfamily of steroid/thyroid hormone receptors characterized by a common structure in which the different functions (trans-activation, DNA binding and ligand binding) are present in discrete modular domains in the protein. Retinoid...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To conduct an analysis of associations between eating behaviours and weight status in 2-year-old children. SUBJECTS/METHODS:Data were collected prospectively in the maternal-infant dyad Cork BASELINE Birth Cohort Study. The weight status of children aged 2 years (n=1189) was assigned using the In...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2015.130
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Additional strategies should be applied to optimize hospital food services, in order to increase the number of patients with adequate protein intake at mealtimes. Therefore, we aim to specify the differences in protein intake per mealtime between the traditional three meals a day food service (TMS...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0288-6
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:We set up a baseline data on urinary iodine excretion from a nationwide representative sample of rural schoolchildren before instituting iodine supplementation. DESIGN:Stratified multistage cluster sampling in three different strata: lowlands, foothills and mountainous areas. Early morning urine samples were...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600562
更新日期：1998-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective study on the prevalence of these disorders in a large cohort of 318 female patients with AN...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.115
更新日期：2016-11-01 00:00:00
abstract：:An oat bran concentrate was prepared by removing non-fibre components by cold-water wet-milling, resulting in a 2- to 3-fold concentration of soluble fibre, with beta-D-glucan as its main component. The concentrate was baked in bread which was consumed for 8 weeks by free-living men with mild to moderate hypercholeste...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1992-09-01 00:00:00
abstract：:The diet of many athletes is inadequate due to overly restrictive habits and an obsession with losing weight in order to maintain a particular level of body weight. Many female athletes, particularly those who participate in sports that emphasize leanness (gymnastics, distance running, diving, figure skating and class...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601483
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Despite the worldwide scientific and media attention, the actual fructose consumption in many non-US populations is not clear. The aim of this study was to estimate the fructose consumption and its main food sources in a representative sample of the general Dutch population. SUBJECTS/METHODS:In a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.267
更新日期：2015-04-01 00:00:00
abstract：OBJECTIVE:To measure the relative effects of each of four phytosterol ester-enriched low-fat foods (bread, breakfast cereal, milk and yoghurt) on serum lipids, plasma phytosterols and carotenoids. DESIGN:: Three research centres undertook a randomised, incomplete crossover, single-blind study consisting of four treatm...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.ejcn.1601837
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:We wished to determine the contributing causes of goitre among pregnant women in rural Bangladesh to provide baseline data before instituting iodine supplementation. DESIGN:All pregnant women in a subdistrict of Modhupur, Bangladesh were assessed for goitre size and were asked to give blood and urine samples...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：OBJECTIVES:Pizza eating has been favourably related to the risk of cardiovascular disease, but the data are limited. To evaluate the potential role of pizza consumption on the risk of acute myocardial infarction (AMI), we considered data from an Italian study. DESIGN:We conducted a hospital-based case-control study on...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601997
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To compare the efficacy of single versus multiple doses of plant sterols on circulating lipid level and cholesterol trafficking. SUBJECTS/METHODS:A randomized, placebo-controlled, three-phase (6 days/phase) crossover, supervised feeding trial was conducted in 19 subjects. Subjects were provided (...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2008.36
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:There is a lack of detailed data on fish consumption in European children and adolescents. We therefore investigated fish consumption patterns, portion sizes and estimated intakes of long-chain n-3 polyunsaturated fatty acids (PUFA; eicosapentaenoic acid, docosahexaenoic acid). SUBJECTS/METHODS:F...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.40
更新日期：2009-09-01 00:00:00
