Increase in oxidation resistance of atherogenic serum lipoproteins following antioxidant supplementation: a randomized double-blind placebo-controlled clinical trial.


OBJECTIVE:To test the effect of supplementation of diet with ascorbic acid, selenium, alpha-tocopherol and beta-carotene on the oxidation resistance of very low (VLDL) + low density lipoprotein (LDL). DESIGN:A randomized placebo-controlled double-masked clinical trial. SETTING:In healthy men aged 30-58 years smoking regularly 15-40 cigarettes/day. SUBJECTS:Forty subjects recruited from the general population, who all completed the study. INTERVENTION:400 mg of slow release ascorbic acid, 100 micrograms of organic selenium, 200 mg of D-alpha-tocopheryl acetate and 30 mg of beta-carotene daily or placebo, 20 men in each group for 3 months. MAIN OUTCOME MEASURES:The oxidation resistance of VLDL + LDL measured by inducing oxidation with copper chloride and, separately, with a combination of haemin and H2O2. RESULTS:In plasma, alpha-tocopherol increased by 72%, beta-carotene by 209%, ascorbate by 45% and selenium by 20% in the supplemented men. The lag time to oxidation increased by 27% [95% confidence interval (CI) 18-35%, P < 0.001] after copper and by 29% (95% CI 12-46%, P = 0.002) after haemin plus H2O2 in the supplemented group as compared to the placebo group by t-tests. The respective net changes in the maximal oxidation velocity were a reduction of 10% (95% CI 1-21%, P = 0.037) after copper and a reduction of 15% (95% CI-1 to 30%, P = 0.070) after haemin and H2O2. CONCLUSIONS:These findings provide further confirmation for the notion that the supplementation of diet with antioxidative vitamins and selenium increases the oxidation resistance of atherogenic lipoproteins in human plasma.


Eur J Clin Nutr


Nyyssönen K,Porkkala E,Salonen R,Korpela H,Salonen JT


Has Abstract


1994-09-01 00:00:00












  • Serum trace elements in Zairian mothers and their newborns.

    abstract:OBJECTIVES:Pregnant women in developing countries might be at risk of trace element deficiencies. These deficiencies could have deleterious effects on fetus. Therefore, serum trace elements were determined at delivery in Zairian mothers and their newborns. DESIGN:Prospective study. SETTING:Maternity ward of Kinshasa ...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Arnaud J,Preziosi P,Mashako L,Galan P,Nsibu C,Favier A,Kapongo C,Hercberg S

    更新日期:1994-05-01 00:00:00

  • The effect of dietary trans alpha-linolenic acid on plasma lipids and platelet fatty acid composition: the TransLinE study.

    abstract:OBJECTIVE:To collect (i) baseline data and (ii) execute a large multicentre study examining the effect of trans alpha-linolenic acid on its incorporation into plasma lipids and on risk factors for coronary heart disease. DESIGN:Male volunteers were recruited and the habitual diet assessed by a 4-d weighed record. Fatt...

    journal_title:European journal of clinical nutrition

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sébédio JL,Vermunt SH,Chardigny JM,Beaufrère B,Mensink RP,Armstrong RA,Christie WW,Niemelä J,Hénon G,Riemersma RA

    更新日期:2000-02-01 00:00:00

  • A study of protein turnover in preterm neonates using 15N enrichment of urinary ammonia.

    abstract::Hydrolysed yeast protein labelled with 15N was used to measure protein turnover, protein synthesis and protein breakdown in preterm infants. The yeast tracer was given as a bolus intragastric dose and protein turnover was determined from the 15N enrichment of urinary ammonia over known periods of about 12 h. Six boys ...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Stack T,Reeds P,Preston T,Hay S,Lloyd DJ,Aggett PJ

    更新日期:1990-03-01 00:00:00

  • The effect of acute fluid consumption on measures of impedance and percent body fat using leg-to-leg bioelectrical impedance analysis.

    abstract:OBJECTIVE:To examine the effect of acute fluid consumption on measures of impedance and percent body fat (%BF) using a common leg-to-leg bioelectrical impedance analyzer system. DESIGN:Cross-sectional design with treatment order determined using a counterbalanced assignment. SETTING:University laboratory. SUBJECTS:I...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,随机对照试验


    authors: Dixon CB,LoVallo SJ,Andreacci JL,Goss FL

    更新日期:2006-01-01 00:00:00

  • Variation of major neutral oligosaccharides levels in human colostrum.

    abstract:OBJECTIVES:Human colostrum is known to be important for the protection of infants against infection by pathogenic microorganisms. This protection is thought to be due, partially, to various neutral and acidic oligosaccharides that are present in colostrum and milk. However, the concentrations of each of the oligosaccha...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Asakuma S,Urashima T,Akahori M,Obayashi H,Nakamura T,Kimura K,Watanabe Y,Arai I,Sanai Y

    更新日期:2008-04-01 00:00:00

  • Energy metabolism and requirements in different ethnic groups.

    abstract::Some studies on energy metabolism of men and women in Third World countries suggested that their basal metabolic rate (BMR) is lower compared to BMRs of people in Northern European and American countries. It is, however, not clear whether this results from ethnic factors, climate or adaptation to, for instance, a low ...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: de Boer JO,van Es AJ,Voorrips LE,Blokstra F,Vogt JE

    更新日期:1988-12-01 00:00:00

  • Anthropometric reference data for elderly Swedes and its disease-related pattern.

    abstract:BACKGROUND/OBJECTIVES:Anthropometric measurement is a noninvasive and cost-efficient method for nutritional assessment. The study aims to present age- and gender-specific anthropometric reference data for Swedish elderly in relation to common medical conditions, and also formulate prediction equations for such anthropo...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Gavriilidou NN,Pihlsgård M,Elmståhl S

    更新日期:2015-09-01 00:00:00

  • n-3 fatty acids in human fat tissue aspirates are stable for up to 6 y.

    abstract:OBJECTIVES:The content of n-3 (omega-3) polyunsaturated fatty acids in fat tissue is a valid indicator of their long-term consumption. We studied the stability of n-3 fatty acids in human subcutaneous fat microbiopsies after 6 and 11 y of storage. DESIGN:Microbiopsies were taken from a lump of human adipose tissue and...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Katan MB,Harryvan JL,van de Bovenkamp P

    更新日期:2003-07-01 00:00:00

  • Complex interactions with infection and diet may explain seasonal growth responses to vitamin A in preschool aged Indonesian children.

    abstract:OBJECTIVE:To explore the potential contribution of respiratory infections and vitamin A intakes to the seasonal effect of vitamin A supplementation on child growth. METHODS:Data from a randomized double-blind placebo-controlled trial, in which a single high dose of vitamin A or placebo was given every 4 months to 1405...

    journal_title:European journal of clinical nutrition

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hadi H,Dibley MJ,West KP Jr

    更新日期:2004-07-01 00:00:00

  • Hyponatremia and hypokalemia as risk factors for falls.

    abstract:BACKGROUND/OBJECTIVES:Fall accidents may reduce an individual's quality of life and ability to perform the activities of daily life, and may delay recovery from illness. Consequently, medical institutions need to take measures to prevent falls. There are various risk factors for falls, including advanced age, illness a...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Tachi T,Yokoi T,Goto C,Umeda M,Noguchi Y,Yasuda M,Minamitani M,Mizui T,Tsuchiya T,Teramachi H

    更新日期:2015-02-01 00:00:00

  • Prospective study on milk products, calcium and cancers of the colon and rectum.

    abstract:OBJECTIVE:To study the relationship between consumption of milk and milk products, calcium, lactose and vitamin D and occurrence of colorectal cancers. DESIGN:Prospective cohort study. SUBJECTS:A total of 9959 men and women aged 15 y or older without history of cancer at baseline. During a 24 y follow-up, 72 new canc...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Järvinen R,Knekt P,Hakulinen T,Aromaa A

    更新日期:2001-11-01 00:00:00

  • Quantification of dietary intake in long-stay geriatric patients: do we need seven days observation?

    abstract::Nutrient intake was assessed for 15 long-stay elderly patients by 7-d weighed inventory. Analysis revealed neither significant day-to-day nor weekday/weekend variations for any studied nutrient except fibre. It would appear that acceptable indications of customary intake in this population can be achieved by measureme...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Barnes KE,Hodkinson HM

    更新日期:1988-06-01 00:00:00

  • Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial.

    abstract:BACKGROUND/OBJECTIVES:Hypertension affects about 30% of adults worldwide. Garlic has blood pressure-lowering properties and the mechanism of action is biologically plausible. Our trial assessed the effect, dose-response, tolerability and acceptability of different doses of aged garlic extract as an adjunct treatment to...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,随机对照试验


    authors: Ried K,Frank OR,Stocks NP

    更新日期:2013-01-01 00:00:00

  • Predictors of serum cobalamin and its association with homocysteine in community-dwelling older adults.

    abstract:BACKGROUND/OBJECTIVES:This study investigates the predictors of serum cobalamin concentrations in community-dwelling older adults and the relationship between serum cobalamin and plasma homocysteine. SUBJECTS/METHODS:Serum cobalamin and plasma homocysteine were measured by SimulTRAC-SNB radio assay and HPLC, respectiv...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Jungert A,Neuhäuser-Berthold M

    更新日期:2019-09-01 00:00:00

  • Variation in selenoprotein P concentration in serum from different European regions.

    abstract:OBJECTIVE:To study the variation in selenoprotein P levels in serum among healthy subjects from 17 European regions representing nine countries. SUBJECTS:Survey of 414 37-70-year-old subjects (197/217 males/females) from 17 regions. RESULTS:The level of selenoprotein P varied significantly among regions and countries...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Marchaluk E,Persson-Moschos M,Thorling EB,Akesson B

    更新日期:1995-01-01 00:00:00

  • Losses of vitamin A and E in parenteral nutrition suitable for premature infants.

    abstract:OBJECTIVE:To assess the bioavailability of vitamins A and E administered parenterally with either water-soluble or lipid-soluble preparations. STUDY DESIGN:A water soluble preparation (MVI Pediatric) administered with a glucose-amino acid solution and a lipid soluble preparation (Vitalipid N Infant) infused with a lip...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Haas C,Genzel-Boroviczény O,Koletzko B

    更新日期:2002-09-01 00:00:00

  • Five decades of trends in anemia in Israeli infants: implications for food fortification policy.

    abstract:OBJECTIVE:To describe the secular trends in the prevalence rates of iron-deficiency anemia (IDA) in infants in Israel, identify population group differences and assess the effectiveness of the 1985 Public Health directives on iron supplementation and avoidance of cow's milk in the first year of life. DESIGN:A systemat...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Kaluski DN,Leventhal A,Averbuch Y,Rishpon S,Cohen-Dar M,Habib S,Bellmaker I,Rubin L,Rachmiel S,Amitai Y,Palti H

    更新日期:2001-02-01 00:00:00

  • Design and characterization of dietary assessment in the German National Cohort.

    abstract:BACKGROUND/OBJECTIVES:The aim of the study was to describe a novel dietary assessment strategy based on two instruments complemented by information from an external population applied to estimate usual food intake in the large-scale multicenter German National Cohort (GNC). As proof of concept, we applied the assessmen...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Knüppel S,Clemens M,Conrad J,Gastell S,Michels KB,Leitzmann M,Krist L,Pischon T,Krause G,Ahrens W,Ebert N,Jöckel KH,Kluttig A,Obi N,Kaaks R,Lieb W,Schipf S,Brenner H,Heuer T,Harttig U,Linseisen J,Nöthlings U,B

    更新日期:2019-11-01 00:00:00

  • Body mass index: a measure of the nutritional status in Indian populations.

    abstract::Anthropometric data available through National Nutrition Monitoring Bureau surveys/studies conducted by the National Institute for Nutrition were analysed to study body mass index (BMI:kg/m2) profiles of adults and relate them to various parameters such as the nutritional status of preschool children, socio-economic s...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,评审


    authors: Naidu AN,Rao NP

    更新日期:1994-11-01 00:00:00

  • Effect of a high monounsaturated fatty acid diet on blood pressure and glucose metabolism in women with gestational diabetes mellitus.

    abstract:OBJECTIVE:The effect of a diet rich in monounsaturated fatty acids (MUFA) on blood pressure, glycemic control, lipids and insulin sensitivity was evaluated in women with gestational diabetes mellitus. DESIGN AND METHODS:A randomized, unpaired diet intervention was performed in 27 women with gestational diabetes mellit...

    journal_title:European journal of clinical nutrition

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lauszus FF,Rasmussen OW,Henriksen JE,Klebe JG,Jensen L,Lauszus KS,Hermansen K

    更新日期:2001-06-01 00:00:00

  • Poor complementary feeding practices and high anaemia prevalence among infants and young children in rural central and western China.

    abstract:BACKGROUND/OBJECTIVES:Infant and young child feeding (IYCF) has not been documented in central and western China, where anaemia is prevalent. To support policy advocacy, we assessed IYCF and anaemia there using standardized methods. SUBJECTS/METHODS:A community-based, cross-sectional survey of 2244 children aged 6-23 ...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Hipgrave DB,Fu X,Zhou H,Jin Y,Wang X,Chang S,Scherpbier RW,Wang Y,Guo S

    更新日期:2014-08-01 00:00:00

  • Intra-abdominal and subcutaneous abdominal fat as predictors of cardiometabolic risk in a sample of Mexican children.

    abstract:BACKGROUND/OBJECTIVE:Few studies in Latin American paediatric populations have differentiated fat deposits in specific areas, such as intra-abdominal fat (IAF) and subcutaneous abdominal fat (SAF). Research in diverse populations is needed, as patterns of fat accumulation vary by ethnicity. The aim of this study was to...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: González-Álvarez C,Ramos-Ibáñez N,Azprioz-Leehan J,Ortiz-Hernández L

    更新日期:2017-09-01 00:00:00

  • Bone status measured by quantitative ultrasound: a comparison with DXA in Thai children.

    abstract:BACKGROUND/OBJECTIVES:Quantitative ultrasound (QUS) is used to measure bone quality and is known to be safe, radiation free and relatively inexpensive compared with dual-energy X-ray absorptiometry (DXA) that is considered the gold standard for bone status assessments. However, there is no consensus regarding the valid...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Srichan W,Thasanasuwan W,Kijboonchoo K,Rojroongwasinkul N,Wimonpeerapattana W,Khouw I,Deurenberg P

    更新日期:2016-08-01 00:00:00

  • Predictive equations for basal metabolic rates of Indian males.

    abstract::The article deals with the generation of a prediction equation for basal metabolic rate (BMR) of well-nourished Indian males, from prospective measurements on 121 males, using a single validated technique. The equation related BMR to simple measures such as weight (WT) and age, and was given by: BMR (kJ/d) = 48.7 * WT...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,评审


    authors: Soares MJ,Francis DG,Shetty PS

    更新日期:1993-06-01 00:00:00

  • Correlates of regular fish consumption in French elderly community dwellers: data from the Three-City study.

    abstract:OBJECTIVE:Several studies have found an inverse association between fish consumption and risk of dementia. The objective of this study was to describe the characteristics of older fish consumers, in order to identify potential confounders in this relationship. DESIGN:Cross-sectional analysis of the baseline data of a ...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,多中心研究


    authors: Barberger-Gateau P,Jutand MA,Letenneur L,Larrieu S,Tavernier B,Berr C,3C Study Group.

    更新日期:2005-07-01 00:00:00

  • Variation in measures of urea kinetics over four years in a single adult.

    abstract::Urea kinetics was measured in a single woman on five occasions over four years by the prime/intermittent oral-dose method with [15N15N]-urea. On a nitrogen intake of 231 +/- 24 mg/kg/day, urea production was 198 +/- 22 mg/kg/day, with the urinary excretion of urea being 143 +/- 25 mg/kg/day. Urea hydrolysis and salvag...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Hibbert JM,Jackson AA

    更新日期:1991-07-01 00:00:00

  • Weight and height growth of malnourished school-age children during re-feeding. Three historic studies published shortly after World War I.

    abstract:BACKGROUND:In view of the ongoing debate on "chronic malnutrition" and the concept of "stunting" as "a better measure than underweight of the cumulative effects of undernutrition and infection (WHO)", we translate, briefly comment and re-publish three seminal historic papers on catch-up growth following re-feeding afte...

    journal_title:European journal of clinical nutrition

    pub_type: 历史文章,杂志文章,评审


    authors: Hermanussen M,Bilogub M,Lindl AC,Harper D,Mansukoski L,Scheffler C

    更新日期:2018-12-01 00:00:00

  • Comparative studies on Asian and Caucasian children. 2: Nutrition, feeding practices and health.

    abstract::The growth of children whose parents originated from the Indian subcontinent (Asians) and of indigenous, white children in Rochdale (Caucasians) has been related to dietary intake which was estimated by 3-day weighed intakes during a longitudinal study at 3, 6, 9, 12 and 24 months of age. The use of human milk vis-à-v...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Warrington S,Storey DM

    更新日期:1988-01-01 00:00:00

  • Glycaemic, uricaemic and blood pressure response to beverages with partial fructose replacement of sucrose.

    abstract:BACKGROUND/OBJECTIVES:The European Food Safety Authority approved a health claim (ID558) relating to lowered postprandial glycaemia when fructose replaces 30% of sucrose in foods and beverages. We assessed the effects of partial replacement of sucrose with fructose on serum glucose, uric acid and blood pressure. SUBJE...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章,随机对照试验


    authors: Rodrigues N,Peng M,Oey I,Venn BJ

    更新日期:2018-12-01 00:00:00

  • Relevance of non-nutritional calories in mechanically ventilated critically ill patients.

    abstract:BACKGROUND/OBJECTIVES:Overfeeding in critically ill patients is associated with many complications. Propofol, dextrose infusion and citrate dialysis provide non-nutritional calories (NNCs), potentially causing overfeeding. The relevance of NNCs for total caloric intake has not been systematically studied. SUBJECTS/MET...

    journal_title:European journal of clinical nutrition

    pub_type: 杂志文章


    authors: Bousie E,van Blokland D,Lammers HJ,van Zanten AR

    更新日期:2016-12-01 00:00:00