Abstract：
OBJECTIVE:Recent studies suggest that subtle vitamin K depletion has far-reaching consequences. As this entity is not associated with prothrombin time elevation, it is important to determine whether alternate methods can help identify it. We investigated subtle vitamin K depletion in a hospital setting and determined whether protein calorie malnutrition predicts its presence. DESIGN, SETTING, SUBJECTS:Using a high-pressure liquid chromatography (HPLC) assay of plasma phylloquinone and a food frequency questionnaire for phylloquinone intake, we examined the phylloquinone status of 27 hospitalized patients with normal coagulation parameters, no liver disease, and no recent warfarin use. We assessed protein-calorie nutritional status with Reilly's criteria and anthropometrics. RESULTS:51% of patients (95% CI = 31% to 70%) had evidence of subtle vitamin K depletion as defined by a subnormal plasma phylloquinone concentration. Patients whose phylloquinone intake was less than the Recommended Daily Allowance (RDA) over the preceding year had lower plasma phylloquinone concentrations when compared to other patients: median (range) 0.106 nmol/l (0.022-0.461) versus 0.301 nmol/l (0.067-3.928), respectively (P = 0.023). Plasma phylloquinone concentrations were no different, however, between well-nourished and malnourished patients: median (range) 0.245 nmol/l (0.022-0.522) versus 0.188 nmol/l (0.067-3.928), respectively (P=0.782). CONCLUSIONS:Subtle vitamin K depletion is common among hospitalized patients and protein-calorie malnutrition does not predict its presence.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Jatoi A,Lennon C,O'Brien M,Booth SL,Sadowski J,Mason JBdoi
10.1038/sj.ejcn.1600670subject
Has Abstractpub_date
1998-12-01 00:00:00pages
934-7issue
12eissn
0954-3007issn
1476-5640journal_volume
52pub_type
杂志文章abstract：OBJECTIVE:Assess longitudinal changes in height, body weight, triceps skinfold thickness and circumferences in elderly Europeans. DESIGN:Longitudinal study including baseline measurements taken in 1988/1989 which were repeated in 1993. SETTING:Baseline and follow-up data were collected in nine European research towns...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:Dietary counseling and intervention based on application of conventional criteria have been ineffective in preventing the progressive weight loss associated with HIV infection. The aim of the study was to compare the progression of clinical and nutritional indicators during nutritional supplementation with or...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601276
更新日期：2001-12-01 00:00:00
abstract：:Food composition tables were studied from nine European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC): Denmark, France, Germany, Greece, Great Britain, Italy, The Netherlands, Spain and Sweden. They were compared from the point view of availability, definition, anal...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600677
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:The aim was to examine the concordance of diet with the recommended cholesterol lowering diet in Coronary Heart Disease (CHD) patients receiving usual care. DESIGN:CHD patients were selected for a survey from hospital records at least six months after hospitalization. Four patient groups divided according to...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600549
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:A major goal of the European Food Information Resource (EuroFIR) Network of Excellence is to provide tools to overcome existing differences among member states and parties with respect to documentation and interchange of food composition data. Establishment of a common CEN (Comité Européen de Norm...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.210
更新日期：2010-11-01 00:00:00
abstract：:Efforts to combat nutrient deficiencies have centered on supplemental nutrient administration and addition of selected nutrients to the food chain in the form of food fortification. Over the past several decades, and as the association between diet and chronic diseases became apparent, supplementation and fortificatio...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601803
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To examine the coherence of estimated intakes of acrylamide (AA) from foods, with hemoglobin (Hb) AA adduct levels, an objective marker of environmental AA exposure. DESIGN:A cross-sectional study. SETTING:The Malmö Diet and Cancer study, a large population-based prospective cohort (n=28 098) in the south o...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602704
更新日期：2008-03-01 00:00:00
abstract：:The effect of mazindol given orally on gastric emptying of a radiolabelled solid meal was examined in 10 obese females. The patients underwent the measurement of gastric emptying twice: 2 mg mazindol was compared with placebo according to a double-blind study protocol. Mazindol significantly delayed gastric emptying (...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:There are positive associations between pulmonary function (PF) and fat-free mass as well as muscle strength. Contrarily, negative associations were found with indirect measures of visceral adipose tissue (VAT). We aimed to differentiate between associations of body composition and PF by assessing...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.146
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:This study evaluates the feasibility among preschoolers of the 2 × 24-h dietary recalls (24-HDRs) method combined with a food-recording booklet (FRB), using EPIC-Soft pc-program for the 24-HDR (the software developed to conduct 24-HDRs in the European Prospective Investigation into Cancer and Nutr...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.91
更新日期：2011-07-01 00:00:00
abstract：:Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trial...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,meta分析,评审
doi：10.1038/ejcn.2017.55
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Youth with type 1 diabetes (T1DM) are at substantially increased risk for adverse vascular outcomes, but little is known about the influence of dietary behavior on cardiovascular disease (CVD) risk profile. We aimed to identify dietary intake patterns associated with CVD risk factors and evaluate ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2014.96
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Improving dietary status is an important development objective, but monitoring of progress in this area can be too costly for many low-income countries. This paper demonstrates a simple, inexpensive technique for monitoring household diets in Mozambique. DESIGN:Secondary analysis of data from an intensive fi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601671
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To monitor the dietary intake of energy, macro- and micronutrients in asylum seeker children. DESIGN AND SETTING:Cross-sectional study in three asylum seeker centres in The Netherlands. SUBJECTS:Hundred and sixteen children 2-12 years old (86% of the study cohort) provided a dietary history. METHOD:The die...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602501
更新日期：2007-01-01 00:00:00
abstract：:The additional energy requirements of pregnancy are needed for increases in maternal (breast, uterus and adipose) and feto-placental tissue accrued during pregnancy as well as the additional running cost of pregnancy for example increased cardiac output. Based on prospective longitudinal studies, the additional energy...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600753
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:To provide a reference range for plasma total homocysteine (tHcy), an independent risk factor for vascular disease, and to explore relationships with nutritional indices for people aged 65 y and over, in the UK National Diet and Nutrition Survey (NDNS). DESIGN:The survey procedures described in the National...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600468
更新日期：1997-10-01 00:00:00
abstract：OBJECTIVE:Research on the impact of maternal physical activity on pregnancy outcomes has often employed subjective measures of physical activity obtained by diary or questionnaire. This study investigates the feasibility of using accelerometry as an objective measure of physical activity of pregnant women compared with...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602329
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To study the association between dietary and serum antioxidant vitamins and carotenoids and risk for colorectal cancer in male smokers. DESIGN:A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with alpha-tocopherol (50 mg/day), beta-carotene (20 mg...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601366
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Recent epidemiological data have shown that abdominal fat accumulation is associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This study aimed to investigate the association between visceral adiposity and coronary artery calcification (CAC) in CKD ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.66
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Vitamin B(12) (B(12)) deficiency is common in Indians and a major contributor to hyperhomocysteinemia, which may influence fetal growth, risk of type II diabetes and cardiovascular disease. The purpose of this paper was to study the effect of physiological doses of B(12) and folic acid on plasma t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2010.15
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between the common cold and vitamin C supplementation. DESIGN:A double-blind, 5-year randomized controlled trial. SETTING:A village in Akita prefecture, one of the regions in Japan with the highest mortality from gastric cancer. SUBJECTS:Participants in annual screening prog...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602261
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:To study the association between content in adipose tissue of very long-chain n-3 fatty acids, trans fatty acids, linoleic acid and alpha-linolenic acid and risk of a first myocardial infarction. DESIGN AND SUBJECTS:A case-control design among 100 patients and 98 population controls both men and postmenopau...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601064
更新日期：2000-08-01 00:00:00
abstract：:The present study tested the hypotheses that: (a) individual body composition estimates obtained with the Durnin-Womersley (D-W) equations have low validity in certain populations in developing countries; (b) there exists a poor relationship between the body mass index (BMI) and body composition estimates (fat mass (B...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Changes in lifestyle and increases in sedentary activities during recent decades have been shown to contribute to the prevalence of overweight in adolescents. OBJECTIVES:To determine the inter-individual variability and the day-to-day variations in daily energy expenditure (DEE) and activity pattern, and th...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601395
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Older people are becoming an increasingly important proportion of the populations of developing countries, yet little information exists on their nutritional status or social conditions. OBJECTIVE:To assess the nutritional status of older people in rural Malawi. DESIGN:Cross-sectional study. SETTING:Lilon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600617
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:The anthropometric measurement of mid-arm muscular area (MAMA) involves overestimation because of various assumptions, this overestimation being progressive with increasing adiposity. However, the effects of muscle atrophy and variation of the subcutaneous fat thickness have remained uncertain. OBJECTIVES:T...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.87
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVES:To identify the types and quantities of 'extra' foods, or energy-dense, nutrient-poor foods, consumed by Australian adults, and assess their contribution to total energy and nutrient intakes. SUBJECT/METHODS:We used 24-h recall data from 10 851 adults, aged 19 years and over, who participated in the nationa...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2008.51
更新日期：2009-07-01 00:00:00
abstract：:Skeletal growth and changes in body composition during growth present important variations; body mass index and lean body mass related to age show important gender differences. The process of ossification is developed in two different ways, endochondral and intramembraneous. The former is characterised by the formatio...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600976
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS:Case-control study. Cases were 555 women (mean age 31 years, range 16-43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The contro...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602419
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVES:Pregnant women in developing countries might be at risk of trace element deficiencies. These deficiencies could have deleterious effects on fetus. Therefore, serum trace elements were determined at delivery in Zairian mothers and their newborns. DESIGN:Prospective study. SETTING:Maternity ward of Kinshasa ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
