Abstract:
BACKGROUND/OBJECTIVES:Youth with type 1 diabetes (T1DM) are at substantially increased risk for adverse vascular outcomes, but little is known about the influence of dietary behavior on cardiovascular disease (CVD) risk profile. We aimed to identify dietary intake patterns associated with CVD risk factors and evaluate their impact on arterial stiffness (AS) measures collected thereafter in a cohort of youth with T1DM. SUBJECTS/METHODS:Baseline diet data from a food frequency questionnaire and CVD risk factors (triglycerides, low density lipoprotein-cholesterol, systolic blood pressure, hemoglobin A1c, C-reactive protein and waist circumference) were available for 1153 youth aged ⩾10 years with T1DM from the SEARCH for Diabetes in Youth Study. A dietary intake pattern was identified using 33 food groups as predictors and six CVD risk factors as responses in reduced rank regression (RRR) analysis. Associations of this RRR-derived dietary pattern with AS measures (augmentation index (AIx75), n=229; pulse wave velocity, n=237; and brachial distensibility, n=228) were then assessed using linear regression. RESULTS:The RRR-derived pattern was characterized by high intakes of sugar-sweetened beverages (SSB) and diet soda, eggs, potatoes and high-fat meats and low intakes of sweets/desserts and low-fat dairy; major contributors were SSB and diet soda. This pattern captured the largest variability in adverse CVD risk profile and was subsequently associated with AIx75 (β=0.47; P<0.01). The mean difference in AIx75 concentration between the highest and the lowest dietary pattern quartiles was 4.3% in fully adjusted model. CONCLUSIONS:Intervention strategies to reduce consumption of unhealthy foods and beverages among youth with T1DM may significantly improve CVD risk profile and ultimately reduce the risk for AS.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Lamichhane AP,Liese AD,Urbina EM,Crandell JL,Jaacks LM,Dabelea D,Black MH,Merchant AT,Mayer-Davis EJdoi
10.1038/ejcn.2014.96subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1327-33issue
12eissn
0954-3007issn
1476-5640pii
ejcn201496journal_volume
68pub_type
杂志文章,多中心研究abstract::Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trial...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous small studies have shown either no difference or a lower risk of symptomatic gallstone disease in vegetarians than in non-vegetarians. This study examined the incidence of symptomatic gallstone disease in a cohort of British vegetarians and non-vegetarians, and investigated the associatio...
journal_title:European journal of clinical nutrition
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.146
更新日期:2017-03-01 00:00:00
abstract::Ingested protein is made available to the body following digestion and absorption as amino acids and contributes to the body's demand for amino acids for protein synthesis and other metabolic pathways. As the pattern of amino acids required for metabolism is substantially different from that ingested, extensive metabo...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/sj.ejcn.1600743
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abstract::As part of the Euronut SENECA study, food consumption has been assessed in 1217 men and 1241 women, born between 1913 and 1918 and living in 18 towns in 12 European countries. The method used was a standardized modified dietary history, including a 3-day estimated record and a food frequency list based on local food p...
journal_title:European journal of clinical nutrition
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更新日期:1991-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:A major goal of the European Food Information Resource (EuroFIR) Network of Excellence is to provide tools to overcome existing differences among member states and parties with respect to documentation and interchange of food composition data. Establishment of a common CEN (Comité Européen de Norm...
journal_title:European journal of clinical nutrition
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abstract:OBJECTIVE:To evaluate the bifidogenic efficacy of two inulin doses in healthy human adults. DESIGN:A double-blind, placebo-controlled, crossover human study. SETTING:Food Microbial Sciences Unit, The University of Reading, Reading, UK. SUBJECTS:Thirty healthy volunteers, 15 men, 15 women (age range 19-35). INTERVEN...
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更新日期:2007-10-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
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更新日期:2019-07-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2015-12-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-04-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602239
更新日期:2005-10-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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更新日期:2009-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2005-11-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2004-11-01 00:00:00
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更新日期:2006-08-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2017-04-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-11-01 00:00:00
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journal_title:European journal of clinical nutrition
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更新日期:2019-01-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-07-01 00:00:00
abstract::The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
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更新日期:2007-03-01 00:00:00