Abstract:
OBJECTIVE:To study the association between dietary and serum antioxidant vitamins and carotenoids and risk for colorectal cancer in male smokers. DESIGN:A prospective cohort study within a randomised, double-blind, placebo-controlled trial testing supplementation with alpha-tocopherol (50 mg/day), beta-carotene (20 mg/day) or both in preventing cancer. SUBJECTS AND METHODS:Participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with complete dietary data and serum samples available from baseline. These included 26,951 middle-aged male smokers among whom 184 colorectal cancer cases were diagnosed during 8 y of follow-up. Relative risks were calculated with Cox proportional hazards models adjusting for trial supplementation, age, body mass index, serum cholesterol, cigarettes smoked per day and physical activity. RESULTS:There was no significant association between dietary vitamin C or E, alpha-or gamma-tocopherol, retinol, alpha- or beta-carotene, lycopene or lutein+zeaxanthin and risk for colorectal cancer. Serum alpha-tocopherol, beta-carotene or retinol was also not associated with the risk, neither did the season when baseline blood was drawn modify the relationship between serum beta-carotene and colorectal cancer risk. CONCLUSIONS:Our data support the results from previous studies in which no association between dietary antioxidant vitamins and carotenoids and risk for colorectal cancer has been observed. Likewise, no association between baseline serum antioxidant concentrations and colorectal cancer risk was evident. SPONSORSHIP:The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study was supported by a contract with the US National Cancer Institute (N01-CN-45165).
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Malila N,Virtamo J,Virtanen M,Pietinen P,Albanes D,Teppo Ldoi
10.1038/sj.ejcn.1601366subject
Has Abstractpub_date
2002-07-01 00:00:00pages
615-21issue
7eissn
0954-3007issn
1476-5640journal_volume
56pub_type
临床试验,杂志文章,随机对照试验abstract::The application of molecular biology and genetics in the field of cholesterol and lipoprotein metabolism has resulted in a tremendous expansion of knowledge during the past decade. In this short review, the normal metabolism of lipoproteins is first discussed briefly, and several clinically important examples of genet...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::The purpose of this study was to investigate the relationship between dietary antioxidant intake and the risk of subarachnoid hemorrhage (SAH) in a case-control study. An antioxidant intake score was calculated for individual values for each food group (soy products, green yellow-vegetables, fruits, boiled rice and te...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602669
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Several diets, e.g., those low in fruits/vegetables, high in sodium, and red/processed meat, have been related to a higher stroke risk. We investigated stroke mortality associated with a priori diet-quality indices in the Multiethnic Cohort study. SUBJECTS/METHODS:Based on 172,043 observations in...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0103-4
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status. DESIGN:Randomized, controlled, community-based intervention trial. SETTING:Low...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602682
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The hallmark of cystic fibrosis (CF) is chronic lung inflammation. The severity of lung disease is closely correlated with immunoglobulin G (IgG) levels. Beyond its contribution to the bone health, the importance of vitamin D has not been fully recognized owing to the lack of human studies providi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/ejcn.2010.194
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:We have measured urea kinetics in normal adult men and women of different body composition to determine whether adiposity is associated with differences in the rate of urea production or endogenous urea hydrolysis. DESIGN:Urea kinetics were determined from the excretion of [15N15N]urea in urine over a period...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600373
更新日期:1997-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of fatty liver and alanine aminotransferase (ALT) elevation in obese Japanese women and to clarify the factors contributing to fatty change and ALT elevation in the cohort. DESIGN:Cross-sectional and population-based study. SUBJECTS:From 4366 women who received their annual healt...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601956
更新日期:2004-09-01 00:00:00
abstract::A cross-sectional study of children in West Kalimantan, Indonesia, was conducted to examine the relationship between malnutrition history, child IQ, school attendance, socioeconomic status, parental education and parental IQ. In unadjusted analyses, severely stunted children had significantly lower IQ scores than mild...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602103
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To assess the genetic and nongenetic correlates of circulating measures of vitamins K and D status in a community-based sample of men and women. SUBJECTS/METHODS:A cross-sectional study of 1762 participants of the Framingham Offspring Study (919 women; mean age 59 years). Vitamin K status was measured as pla...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602959
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To know the prevalence of malnutrition and to validate a nutritional screening protocol (SP) in patients hospitalised in Hospitals representative of inpatients admitted for acute illnesses in Galicia. DESIGN:Cross-sectional study of 376 randomised patients (189 female, 210 > or =65 y old) from 12 public hosp...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602157
更新日期:2005-08-01 00:00:00
abstract::Both high and low vitamin D statuses have been associated with lower memory function. Apolipoprotein E (APOE) ɛ4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations. This report aims to examine if the presence of APOE ɛ4 alleles contributes to the relationship...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2014.201
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:We investigated the effects of mineral water fortified with folic acid, vitamins B(6), B(12), D and calcium on folate concentrations in serum and erythrocytes, serum vitamin B(12) and plasma homocysteine concentrations in free-living subjects. In addition, we investigated the bioavailability of calcium added ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601795
更新日期:2004-02-01 00:00:00
abstract::The importance of processing conditions, product thickness and effect of egg addition for the glycaemic and hormonal responses to pasta was studied. Healthy subjects were given test meals with an equivalent amount of available carbohydrate from extruded high-temperature dried spaghetti and three varieties of fresh rol...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVES:To compare validation of reported dietary intakes from weighed records against urinary nitrogen excretion and energy expenditure measured by DLW, and to examine the utility of the Goldberg cut-off for EI:BMR in the identification of under-reporters. DESIGN:Energy (EI) and nitrogen (protein) intake (NI) were...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600425
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:The overall objective of the European Food Consumption Validation (EFCOVAL) Project was to further develop and validate a trans-European food consumption method to be used for the evaluation of the intake of foods, nutrients and potentially hazardous chemicals within the European population. SUBJ...
journal_title:European journal of clinical nutrition
pub_type: 社论
doi:10.1038/ejcn.2011.82
更新日期:2011-07-01 00:00:00
abstract::This paper evaluates the safety for humans with regard to consumption of protein hydrolysates and fractions thereof, including bioactive peptides. The available literature on the safety of protein, protein hydrolysates, fractions thereof and free amino acids on relevant food legislation is reviewed and evaluated. A ne...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/ejcn.2009.56
更新日期:2009-10-01 00:00:00
abstract::Changes in plasma insulin and glucose concentrations before and after feeding were measured in six female subjects (post-obese) who had regained a normal body mass after a history of severe obesity (mean weight loss, 37.1 +/- 2.6 kg). The responses of the post-obese group were compared with a group of weight- and age-...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To explore whether mothers' lifetime experiences with their own weight status and related cognitive and affective factors influence child feeding behavior. SUBJECTS/METHODS:Overweight mothers (N = 221) of 4-5 year olds recalled their weight at four time points, and were grouped into weight histor...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-017-0071-0
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Sarcopenia and sarcopenic obesity (SO) are geriatric syndromes leading to physical disability, poor quality of life and death. The aim of this study was to investigate the prevalence of sarcopenia and SO in nursing homes in Turkey and to define local disparities for diagnosing sarcopenia and SO. ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/ejcn.2014.15
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVE:To investigate the separate and combined effect of wine-drinking and other alcoholic beverages on esophageal cancer, in a high wine-consuming population. DESIGN:Combined analysis of two hospital-based case-control studies. SETTING:Major teaching and general hospitals in the greater Milan area and in the pro...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601113
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN:A randomized, double blind, placebo-controlled clinical trial. SETTING:Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS:Twenty-five healthy elderly volun...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600938
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. DESIGN:A prospective...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602412
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:This study investigated whether postprandial metabolic responses to bread could be lowered by substituting high amylose maize starch for a part of the flour. DESIGN AND SUBJECTS:Eight healthy subjects consumed test meals of equivalent nutritional composition based on white wheat bread, bread rich in amylose ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600718
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the age-related decrease in resting energy expenditure (REE) is explained by variations in body composition. DESIGN:In Study 1, adult subjects (20-70 years) from the Quebec Family Study were classified into five different age groups. Body composition was measured by hydrodensitometry to ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602262
更新日期:2006-01-01 00:00:00
abstract::The validity of [15N]glycine and [13C]leucine as tracers for investigating albumin fractional synthetic rate (FSR) has been explored by simultaneous infusion of both amino acids into 5 normal female subjects. Albumin FSR, calculated from the urinary [15N]urea plateau value and the incorporation of arginine into albumi...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. Prospective cohort studies that reported relative risks (RR) with 95%...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析
doi:10.1038/ejcn.2012.5
更新日期:2012-03-01 00:00:00
abstract::Maintaining a good nutritional status is important for immune health and for managing metabolic comorbidities in adults with HIV infection. Little is known about the dietary habits of adults living with HIV infection in the United Kingdom. The aims of this study were to characterise their dietary intakes, and to ident...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.109
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:The prevalence of overweight and obesity in Mexican schoolchildren has increased in the past three decades. Dietary pattern approaches to assess diet have been used to study the relation between nutrition and chronic conditions. OBJECTIVE:The objective of this study is to analyze the association between die...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0598-3
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:The EFCOSUM (European Food Consumption Survey Methods) Project aims at harmonizing food consumption surveys in European countries within the perspective of an overall Public Health Monitoring Programme. Harmonization implies the need for a common framework of procedures and tools, that are applicable and fea...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601431
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To characterize meal patterns in relation to obesity in Swedish women using a simple instrument describing meal frequency, meal types and temporal distribution. DESIGN:Cross-sectional parallel group design. SUBJECTS:Eighty-three obese women from the Swedish Obese Subjects (SOS) study were compared with 94 r...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601387
更新日期:2002-08-01 00:00:00