Abstract:
OBJECTIVES:To study the association between content in adipose tissue of very long-chain n-3 fatty acids, trans fatty acids, linoleic acid and alpha-linolenic acid and risk of a first myocardial infarction. DESIGN AND SUBJECTS:A case-control design among 100 patients and 98 population controls both men and postmenopausal women, age 45-75 y. Adipose tissue fatty acids were determined by gas-liquid chromatography. Intake data were obtained through interview using a validated food frequency questionnaire. RESULTS:Dietary intake and adipose tissue content of the fatty acids studied correlated significantly. Adipose tissue contents of eicosapentaenoic acid (20:5n-3), docosapentaenoic acid (22:5n-3) and docosahexaenoic acid (22:6n-3) were significantly lower while those of trans fatty acids, linoleic and alpha-linolenic acid were significantly higher in patients than in controls. Age and sex adjusted odds ratios (OR) were significantly reduced with increasing quintiles of very long-chain n-3 fatty acids, thus the OR in the fifth compared to the first quintile was 0.23 (95% CI 0.08-0.70). After further adjustment for waist-to-hip ratio, smoking, family history of CHD and content of trans fatty acids, the OR in the highest quintile was 0.17 (95% CI 0.04-0.76) and the P for trend 0. 016. Age and sex adjusted OR was increased in the fifth compared to the first quintile of trans fatty acids (OR 2.81, 95% CI 1.16-6.84), linoleic acid (OR 2.10, 95% CI 0.87-5.07) and alpha-linolenic acid (OR 1.96, 95% CI 0.83-4.61), and P for trend was 0.002, 0.005 and 0. 020, respectively. The trends remained significant after adjustment for waist-to-hip ratio, smoking, and family history of coronary heart disease. Trans fatty acids, linoleic acid and alpha-linolenic acid in adipose tissue were strongly correlated, indicating a common source, most likely margarine. When each of these fatty acid species were adjusted for the two others the trends were no longer significant. CONCLUSION:Intake of very long-chain n-3 fatty acids as reflected in adipose tissue content is inversely associated with risk of myocardial infarction. Trans fatty acids, linoleic and alpha-linolenic acid were intercorrelated and associated with increased risk. It is suggested that the increased risk may be connected to trans fatty acids or to some other factor associated with margarine consumption. European Journal of Clinical Nutrition 54, 618-625.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Pedersen JI,Ringstad J,Almendingen K,Haugen TS,Stensvold I,Thelle DSdoi
10.1038/sj.ejcn.1601064subject
Has Abstractpub_date
2000-08-01 00:00:00pages
618-25issue
8eissn
0954-3007issn
1476-5640journal_volume
54pub_type
杂志文章abstract:OBJECTIVE:Research on the impact of maternal physical activity on pregnancy outcomes has often employed subjective measures of physical activity obtained by diary or questionnaire. This study investigates the feasibility of using accelerometry as an objective measure of physical activity of pregnant women compared with...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602329
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. DESIGN:In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Dat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601909
更新日期:2004-06-01 00:00:00
abstract::The development of atherosclerotic vascular disease is influenced by multiple factors present since early age. Abnormal lipid metabolism, a major cause of atherosclerosis, results from genetic predisposition and is influenced by a variety of exogenous conditions. This article reviews the published studies of serum cho...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To identify dietary patterns, and their socio-demographic and lifestyle correlates in a large sample of Greek adults, and assess their adherence to the traditional Mediterranean diet. DESIGN:Principal component (PC) analysis was used to identify dietary patterns among 28 034 participants of the Greek branch ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,多中心研究
doi:10.1038/sj.ejcn.1601699
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is unknown whether short sleep duration causatively contributes to weight gain. Studies investigating effects of partial sleep deprivation (PSD) on energy balance components report conflicting findings. Our objective was to conduct a systematic review and meta-analysis of human intervention stu...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,meta分析,评审
doi:10.1038/ejcn.2016.201
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Health education and regulatory measures may contribute to lower population salt intake. Therefore, we aimed to describe knowledge and behaviors related to salt intake in Mozambique. SUBJECTS/METHODS:A cross-sectional evaluation of a representative sample of the population aged 15-64 years (n = 3...
journal_title:European journal of clinical nutrition
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doi:10.1038/s41430-018-0125-y
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abstract::Postprandial thermogenesis was assessed by indirect calorimetry in 32 Gambian women classified into three groups as follows: 12 non-pregnant non-lactating and 10 lactating women studied during the dry season and 10 lactating women studied during the rainy season. The test meal consisted of a typical Gambian breakfast ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The study was designed to evaluate the vitamin D status in women of different physiological status of two socio-economic groups in Bangladesh. DESIGN:A cross-sectional study, using serum 25-hydroxyvitamin D (25-OHD), calcium, phosphorus and alkaline phosphatase activity. SETTING:Two regions of Bangladesh. T...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601284
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.63
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. DESIGN:Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-11-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Maternal dietary patterns were associated with embryonic growth and congenital anomalies. We aim to evaluate associations between early first trimester maternal dietary patterns and embryonic morphological development among pregnancies with non-malformed outcome. SUBJECTS/METHODS:A total of 228 s...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-018-0161-7
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:InBody-770 and SECA mBCA 515 are multifrequency bioelectrical impedance analysis (BIA) devices, which are commonly used in the clinic to assess fat-free mass (FFM) and body fat (BF). However, the accuracy between devices in clinical settings, across different body mass index (BMI) groups remains unclear. ME...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-00839-5
更新日期:2021-01-22 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章
doi:10.1038/sj.ejcn.1602865
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Diet quality indices are increasingly used in nutrition epidemiology as dietary exposures in relation to health outcomes. However, literature on the long-term stability of these indices is limited. We aimed to assess the stability of the validated Framingham Nutritional Risk Score (FNRS) and its c...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.167
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To assess if alcohol drinking is a risk factor for small for gestational age (SGA) birth. METHODS:Case-control study. Cases were 555 women (mean age 31 years, range 16-43) who delivered SGA babies at the Clinica Luigi Mangiagalli and the Obstetric and Gynecology Clinic of the University of Verona. The contro...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602419
更新日期:2006-09-01 00:00:00
abstract::The effect of guar on the absorption of the calcium isotope 45Ca was measured in six normal subjects. Values for the delay before the initial rise of radioactivity in plasma (delta t) and the initial fractional absorption rate (alpha) were derived using a non-linear curve-fitting computer programme. Guar significantly...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS:A...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2012.173
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:Pregnant women in developing countries might be at risk of trace element deficiencies. These deficiencies could have deleterious effects on fetus. Therefore, serum trace elements were determined at delivery in Zairian mothers and their newborns. DESIGN:Prospective study. SETTING:Maternity ward of Kinshasa ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1994-05-01 00:00:00
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journal_title:European journal of clinical nutrition
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doi:10.1038/sj.ejcn.1602411
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pub_type: 杂志文章
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doi:
更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2002-08-01 00:00:00
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doi:10.1038/sj.ejcn.1602601
更新日期:2007-07-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Present study aims to longitudinally explore independent association of physical activity and sedentary behaviors with body weight. SUBJECTS/METHODS:This study included 15050 adults who have complete demographic and dietary data, leisure time physical activity (LTPA) and sedentary behavior evalua...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.262
更新日期:2017-03-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602221
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To study dietary lipid intake and plasma lipid profile of the Hong Kong Chinese population as part of a territory wide survey on cardiovascular risk factors. DESIGN:Randomised age and sex stratified survey. SUBJECTS:1010 subjects aged 25-74 y (500 men, 510 women). MEASUREMENTS:A food frequency method with ...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1600430
更新日期:1997-07-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/ejcn.2014.263
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:The effect of consumption of a wheat-flour bread-based low-fibre diet (7.8 g/day fibre; 1.0 portion) or the same diet in which the wheat bread was exchange for a bread based on oat bran with a high fibre content (31.9 g/day fibre; 1.0 portion) on the ileal excretion of amino acid residues and crude protein w...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-08-01 00:00:00