Abstract：
OBJECTIVES:To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes. DESIGN, SETTING AND SUBJECTS:A total of 21,826 Finnish men and women who were 35-74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n=862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point. RESULTS:Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level > or = 75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level < or = 75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P=0.05) and in both sexes combined (P=0.02). CONCLUSIONS:Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Bidel S,Silventoinen K,Hu G,Lee DH,Kaprio J,Tuomilehto Jdoi
10.1038/sj.ejcn.1602712subject
Has Abstractpub_date
2008-02-01 00:00:00pages
178-85issue
2eissn
0954-3007issn
1476-5640pii
1602712journal_volume
62pub_type
杂志文章abstract：OBJECTIVE:A possible role for vitamin D deficiency in contributing to the winter increase in cardiovascular disease mortality was investigated by testing the effect of vitamin D supplementation on blood pressure and other cardiovascular risk factors during winter. DESIGN:Randomised double-blind trial of vitamin D supp...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess how the glycaemic potency (blood glucose (BG)-raising potential) of breakfast is associated with cognitive function (CF) in school children, taking into account important confounders, including iron status, underlying physiological adaptations and socio-economic status. M...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.96
更新日期：2010-09-01 00:00:00
abstract：:Over the past three decades, undernutrition in Thailand has drastically reduced by over seven times. However, since 1995 the number of patients afflicted with non-communicable diseases, such as diabetes mellitus, has rapidly increased, even among the young. Unhealthy life styles due to urbanization are a major reason ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2017.52
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Fish intake and the long-chain omega-3 polyunsaturated fatty acids (PUFAs) in fish have been suggested to lower the risk of cognitive decline. We assessed whether serum long-chain omega-3 PUFAs eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) are associated w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.59
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, wh...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.28
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:Prevention of cardiovascular diseases by paleolithic or hunter-gatherer diets has been discussed during recent years. METHODS:Our aim was to assess the effect of a paleolithic diet in a pilot study on healthy volunteers during 3 weeks. The intention was to include 20 subjects, of whom 14 fulfilled the study...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602790
更新日期：2008-05-01 00:00:00
abstract：:It has been suggested that energy requirements are either proportional to the BMR (FAO/WHO/UNU, 1985) or to body weight (WHO, 1973). The present analysis sought to distinguish between these two possibilities by determining whether, in rural Gambian women, energy expenditure was more nearly proportional to the BMR or t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:Docosahexaenoic acid (DHA, 22:6n-3), an essential omega 3 fatty acid, may protect against disorders of emotional regulation as well as cardiovascular disease. Animal studies demonstrate that dietary folate can increase tissue concentrations of DHA, although the literature, to date, includes no human studies e...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602321
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Maternal dietary patterns were associated with embryonic growth and congenital anomalies. We aim to evaluate associations between early first trimester maternal dietary patterns and embryonic morphological development among pregnancies with non-malformed outcome. SUBJECTS/METHODS:A total of 228 s...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0161-7
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To study the variation in selenoprotein P levels in serum among healthy subjects from 17 European regions representing nine countries. SUBJECTS:Survey of 414 37-70-year-old subjects (197/217 males/females) from 17 regions. RESULTS:The level of selenoprotein P varied significantly among regions and countries...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Growth parameters during infancy and early childhood might predict adipokine levels later in life. This study investigates the association between peak growth velocities, body mass index (BMI) and age at adiposity rebound (AR), with leptin and adiponectin levels at age 10 years. SUBJECTS/METHODS:...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2013.213
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The cardiovascular benefit of increasing fruit and vegetable (F&V) intake following diagnosis of diabetes remains unknown. We aimed to describe how quantity and variety of F&V intake, and plasma vitamin C, change after diagnosis of type 2 diabetes and examine whether these changes are associated w...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.180
更新日期：2017-01-01 00:00:00
abstract：:A food frequency questionnaire (FFQ) was designed and validated for use in an epidemiological survey measuring coronary heart disease risk factors in British children. The questionnaire asked about the frequency of children's consumption of 35 food items over the previous month and was completed by parents/guardians. ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of fatty liver and alanine aminotransferase (ALT) elevation in obese Japanese women and to clarify the factors contributing to fatty change and ALT elevation in the cohort. DESIGN:Cross-sectional and population-based study. SUBJECTS:From 4366 women who received their annual healt...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601956
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2012.63
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Diet can affect the acid-base status depending on the balance between the intake of acid-inducing foods and base-inducing foods. The purpose of this study was to estimate the dietary acid load and evaluate its association with serum bicarbonate in patients with stages 3 and 4 chronic kidney diseas...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-0689-1
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. DESIGN:A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioecon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2009.99
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the effects of long-term excessive iodine intake on blood lipids in adults. METHODS:Three counties from Dezhou city and Liaocheng city in the Shandong province of China were selected as survey locations. Three to five villages were selected from each county and then cate...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00773-6
更新日期：2020-10-11 00:00:00
abstract：:While putative feedback signals arising from adipose tissue are commonly assumed to provide the molecular links between the body's long-term energy requirements and energy intake, the available evidence suggests that the lean body or fat-free mass (FFM) also plays a role in the drive to eat. A distinction must, howeve...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.256
更新日期：2017-03-01 00:00:00
abstract：OBJECTIVE:To compare nutrition knowledge and food intake in 7-y-old intervention and control children in an atherosclerosis risk factor intervention trial after 6.5 y of nutrition counselling given to the parents. DESIGN, SUBJECTS AND METHODS:Intervention families in the Special Turku Coronary Risk Factor Intervention...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601153
更新日期：2001-04-01 00:00:00
abstract：:The aim of this study was to assess the relationship between obesity and vitamin D status cross-sectionally, the relationship between obesity and the incidence of hypovitaminosis D prospectively and inversely the relationship between vitamin D status and incidence of obesity in a population-based cohort study in Spain...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.48
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:To estimate the current burden of mortality attributable to excess weight in the European Union (EU). METHODS:Prevalence of overweight (body mass index, BMI 25-29.9 kg/m(2)) and obesity (BMI >or=30 kg/m(2)) were based on self-reported data from a survey with samples representative of the 15 EU Member States ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601538
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To investigate the impact of intensive lifestyle education on dietary practices, exercise and metabolic measurements in people with insulin-dependent diabetes mellitus (IDDM). DESIGN:Sixty-one volunteer subjects with IDDM were randomised to intensive (Group 1) or standard (Group 2) education programmes for s...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1600478
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To investigate the association between total alcohol intake and intake of different types of alcoholic beverages in relation to the risk of basal cell (BCC) and squamous cell (SCC) carcinoma of the skin. DESIGN:Prospective cohort study. SETTING:Follow-up data from a community-based skin cancer study in Aust...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602717
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:A constellation of reactive oxygen species (ROS) capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. The consequences of this leads to enhanced oxidative stress and lower antioxidant status. Enzymatic antioxidants provi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602221
更新日期：2005-10-01 00:00:00
abstract：OBJECTIVE:To study the relation between indicators of infection and Schistosoma mansoni and S. haematobium infection, and serum concentrations of zinc, ferritin and retinol. DESIGN:Cross-sectional. SETTING AND SUBJECTS:313 rural Zimbabwean schoolchildren (144 boys and 169 girls, 11-17 years). VARIABLES:S. mansoni an...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：:More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. The predominant mechan...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1601736
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study is to determine whether vitamin D status is associated with incident urinary incontinence (UI) among community-dwelling older adults. SUBJECTS/METHODS:The University of Alabama at Birmingham Study of Aging is a prospective cohort study of community-dwelling Medicare enrollee...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.20
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To describe drinking patterns among individuals who prefer drinking wine, beer or spirits. DESIGN:Cross-sectional study obtaining detailed information on intake of wine, beer and spirits and on frequency of alcohol intake. Adjustment for gender, age, smoking habits, educational attainment and body mass index...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600919
更新日期：2000-02-01 00:00:00
abstract：OBJECTIVE:This study investigated whether postprandial metabolic responses to bread could be lowered by substituting high amylose maize starch for a part of the flour. DESIGN AND SUBJECTS:Eight healthy subjects consumed test meals of equivalent nutritional composition based on white wheat bread, bread rich in amylose ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600718
更新日期：1999-05-01 00:00:00
