Abstract:
:More than a decade has passed since it was unintentionally discovered that grapefruit juice interacts with certain drugs. The coadministration of these drugs with grapefruit juice can markedly elevate drug bioavailability, and can alter pharmacokinetic and pharmacodynamic parameters of the drug. The predominant mechanism for this interaction is the inhibition of cytochrome P-450 3A4 in the small intestine, resulting in a significant reduction of drug presystemic metabolism. An additional mechanism is, presumably, the inhibition of P-glycoprotein, a transporter that carries drug from the enterocyte back to the gut lumen, resulting in a further increase in the fraction of drug absorbed. Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. A single exposure to one glass of the juice can usually produce the maximal magnitude of the interaction. The data available so far, concerning this interaction and its clinical implications, are reviewed in this article. It is likely that more information regarding this interaction will accumulate in the future, and awareness of such is necessary for achieving optimal drug therapy.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Dahan A,Altman Hdoi
10.1038/sj.ejcn.1601736subject
Has Abstractpub_date
2004-01-01 00:00:00pages
1-9issue
1eissn
0954-3007issn
1476-5640pii
1601736journal_volume
58pub_type
杂志文章,评审abstract:OBJECTIVE:[corrected] To study the existence of a graded relationship between the nutrient content of the diet and some measures of social position. DESIGN AND SETTING:The graded relationship hypothesis was verified by secondary analysis performed on two different nutrition surveys: the Quebec Nutrition Survey (QNS) a...
journal_title:European journal of clinical nutrition
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doi:10.1038/sj.ejcn.1601165
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To identify if the nutritional status and improvements in Vietnam during the 1990s applied equally to the key vulnerable population groups (poor, rural, and ethnic minority) as it did to the nonpoor-largely in the urban areas. DESIGN:This study used cross-sectional analyses in the context of inequalities occ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601761
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous small studies have shown either no difference or a lower risk of symptomatic gallstone disease in vegetarians than in non-vegetarians. This study examined the incidence of symptomatic gallstone disease in a cohort of British vegetarians and non-vegetarians, and investigated the associatio...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.252
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:In recent decades, changes in the diet of Brazilians have been characterized by increased consumption of high energy-dense foods, rich in fat and sugar. This study was aimed at assessing diet quality based on the intake of foods with high content of solid fat and added sugars (SoFAS). SUBJECTS/MET...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/s41430-020-0582-y
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abstract:OBJECTIVE:The effect of a diet rich in monounsaturated fatty acids (MUFA) on blood pressure, glycemic control, lipids and insulin sensitivity was evaluated in women with gestational diabetes mellitus. DESIGN AND METHODS:A randomized, unpaired diet intervention was performed in 27 women with gestational diabetes mellit...
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1601193
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:The objective of this study is to determine the relative validity of reported energy intake (EI) derived from multiple 24-h recalls against estimated energy expenditure (EE(est)). Basal metabolic rate (BMR) equations and physical activity factors were incorporated to calculate EE(est). SUBJECTS/ME...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2011.60
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:This study is aimed at investigating the influence of body size, body fat and sexual maturation on blood pressure (BP) in adolescents. DESIGN:A cross-sectional study. SETTING:A suburban student population of Southern Italy. SUBJECTS:One hundred ninety students attending the first and second year of a secon...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600731
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To examine the relationships between TNF-alpha, obesity, and insulin resistance among prepubescent children. DESIGN:Cross-sectional study. SETTING AND SUBJECTS:Data were collected from 112 nondiabetic Latino schoolchildren from public schools in three South Florida communities. Of the enrolled participants,...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601852
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:To describe the influence of maternal weight and weight gain, placental volume and the rate of placental growth in early pregnancy on fetal dimensions measured sonographically. DESIGN:In a prospective study, 712 women were recruited from the antenatal clinic of the University Hospital of the West Indies. Dat...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601909
更新日期:2004-06-01 00:00:00
abstract::Although calcium supplements are widely used in the treatment of osteoporosis their beneficial effect is not conclusively established. The biochemical effects of a calcium supplement (1 g/d) given for between 6 and 36 months were studied in 20 postmenopausal osteoporotic women who had normal calcium absorption. The me...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Previous studies have analysed impacts on average intakes. Agueably however intakes that are of real concern are those which are some distance away from the recommendations. Fiscal measures might have a limited impact on such diets, and as a result, on health. We measure the impact of a fiscal int...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2010.281
更新日期:2011-04-01 00:00:00
abstract::Bioelectrical impedance analysis is an extremely popular method for assessment of body composition. Despite its wide-spread use over the past thirty years, its accuracy and clinical value is still questioned. Most frequently, criticisms focus on its purported poor absolute accuracy and that different impedance analyse...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
doi:10.1038/s41430-018-0335-3
更新日期:2019-02-01 00:00:00
abstract::Adverse reaction to cow's milk and infant formulas are common during infancy. Cow's milk has more than 20 constituents proteins and in principle many are capable of giving rise to an IgE mediated response. The prevalence of cow's milk allergy is between 0.5-10% of the paediatric population (Frier & Kletter, 1970, Gerr...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:To determine the effect of iron supplementation on iron status and endurance capacity. DESIGN:Randomized, double-blind iron supplementation. SETTING:University of Missouri-Columbia and surrounding community. SUBJECTS:Twenty iron-deficient (serum ferritin, sFer<16 microg/l; serum transferrin receptor, sTfR>...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602479
更新日期:2007-01-01 00:00:00
abstract::Bias in diet reporting may be both random and non-random, and may be found with simpler as well as more advanced dietary instruments. A random bias will contribute to obscure relations between diet and disease. A systematic bias may obscure or aggravate such associations. Underreporting of non-protein energy has been ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602589
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:There is experimental evidence that riboflavin (vitamin B2) supplementation reduces oxidative damage and cerebral oedema following acute stroke. OBJECTIVE:To measure riboflavin levels in acute stroke before and after supplementation with this vitamin. DESIGN:Ninety-six acute ischaemic stroke patients had t...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,随机对照试验
doi:10.1038/sj.ejcn.1602666
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To compare the most commonly used equations to predict body fatness from skinfold thickness, in male and female adolescents, with dual-energy X-ray absorptiometry (DXA) as a reference method of fatness measurement. DESIGN:Cross-sectional nutrition survey. SETTING:General adolescent population from Zaragoza ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602226
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:In international surveys of food consumption and nutrient intake, it is essential that the dietary data are comparable when different databases and calculation programs are used. The aim of the present analysis was to examine the comparability of nutrient intake data calculated on the basis of ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601639
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important sit...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2009.32
更新日期:2009-10-01 00:00:00
abstract::A comparison of two methods: analytical and calculation on an estimation of dietary intakes of nitrate and nitrite from six different types of general hospital diets was studied. Studies were performed in the winter season of 1996-1997. It was found that the mean daily intake of nitrates was 85 mg per person in the an...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.66
更新日期:2013-06-01 00:00:00
abstract::Insulin resistance is common and is determined by physiological (aging, physical fitness), pathological (obesity) and genetic factors. The metabolic compensatory response to insulin resistance is hyperinsulinaemia, the primary purpose of which is to maintain normal glucose tolerance. The 'carnivore connection' postula...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Snacking has increased globally. We examine snacking patterns and common snack foods in Brazil. SUBJECTS/METHODS:Data from the first of two non-consecutive food diaries from 34,003 individuals (aged ≥ 10 years) in the first Brazillian nationally representative dietary survey (2008-2009) were used...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2013.60
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Recent studies suggest that subtle vitamin K depletion has far-reaching consequences. As this entity is not associated with prothrombin time elevation, it is important to determine whether alternate methods can help identify it. We investigated subtle vitamin K depletion in a hospital setting and determined w...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1600670
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels ...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1602398
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:We previously demonstrated that acute exposure to hypoxia (3 h at 3000 m) increased oxidative stress markers. Thus, by using the 'living high-training low' (LHTL) method, we further hypothesized that intermittent hypoxia associated with endurance training alters the prooxidant/antioxidant balance....
journal_title:European journal of clinical nutrition
pub_type: 临床试验,杂志文章
doi:10.1038/ejcn.2008.30
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Protein substitutes (PS) are an essential component in the dietary management of phenylketonuria (PKU). PS are available as phenylalanine-free amino-acid mixtures (AAM), glycomacropeptide-based PS (GMP) and large neutral amino acids (LNAA). There is a lack of information regarding their availabili...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/ejcn.2016.54
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:To assess the influence of a low-fat, low-energy diet on the intake of vitamins and minerals in patients with overweight and hyperlipidemia. SETTING:Outpatient clinic for hyperlipidemia treatment. SUBJECTS:A total of 134 subjects chosen from patients attending Outpatient Clinic of Metabolic Diseases. INTE...
journal_title:European journal of clinical nutrition
pub_type: 杂志文章
doi:10.1038/sj.ejcn.1601467
更新日期:2002-12-01 00:00:00