Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women.

Abstract:

BACKGROUND/OBJECTIVE:To investigate the effect of soy protein containing isoflavones on homocysteine (Hcy), C-reactive protein (CRP), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1). SUBJECT/METHODS:In a randomized crossover design, 34 postmenopausal women consumed soy protein isolate (26+/-5 g protein containing 44+/-8 mg isoflavones per day) or milk protein isolate (26+/-5 g protein per day) for 6 weeks each. Fasting blood samples were collected at the end of each diet period and end points analyzed by enzyme-linked immunosorbent assay. RESULTS:Concentrations of Hcy, CRP, sE-selectin, sVCAM-1 and sICAM-1 were not different between soy and milk diet treatments. Results did not differ by equol production status or by baseline lipid concentration. Adjustment for intake of folate and methionine did not alter the Hcy results. CONCLUSIONS:These data suggest that decreasing vascular inflammation and Hcy concentration are not likely mechanisms by which soy consumption reduces coronary heart disease risk.

journal_name

Eur J Clin Nutr

authors

Greany KA,Nettleton JA,Wangen KE,Thomas W,Kurzer MS

doi

10.1038/sj.ejcn.1602885

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1419-25

issue

12

eissn

0954-3007

issn

1476-5640

pii

1602885

journal_volume

62

pub_type

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