ATAC-king the complexity of SAGA during evolution.

abstract：:Here we show that the cell cycle defects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibitor of Cyclin E/cyclin-dependent kinase 2 (CycE/cdk2). The different properties of cells lacking dE2F1/dE2F2 and dE2F1/DAP lead to the surprising observation that dE2F2-mediated repres...

journal_title：Genes & development

authors： Frolov MV,Stevaux O,Moon NS,Dimova D,Kwon EJ,Morris EJ,Dyson NJ

更新日期：2003-03-15 00:00:00

abstract：:The abundance of retinoic acid (RA) is determined by the balance between its synthesis by retinaldehyde dehydrogenase (RALDH) and its degradation by CYP26. In particular, the dynamic expression of three CYP26 genes controls the regional level of RA within the body. Pregastrulation mouse embryos express CYP26 but not R...

journal_title：Genes & development

authors： Uehara M,Yashiro K,Takaoka K,Yamamoto M,Hamada H

更新日期：2009-07-15 00:00:00

abstract：:In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the EGF domain of Vn was...

journal_title：Genes & development

authors： Schnepp B,Donaldson T,Grumbling G,Ostrowski S,Schweitzer R,Shilo BZ,Simcox A

更新日期：1998-04-01 00:00:00

abstract：:Dosage compensation is a process required to balance the expression of X-linked genes between males and females. In Drosophila this is achieved by targeting the dosage compensation complex or the male-specific lethal (MSL) complex to the male X chromosome. In order to study the mechanism of targeting, we have studied ...

journal_title：Genes & development

authors： Kind J,Akhtar A

更新日期：2007-08-15 00:00:00

abstract：:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutat...

journal_title：Genes & development

authors： Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono D

更新日期：2019-01-01 00:00:00

abstract：:We describe the developmental effects of the expression of a normal and mutated Drosophila ras gene ras2 in transgenic Drosophila. A Gly14----Val14 mutant (Gly14 in ras2 is equivalent to Gly12 in mammalian ras proteins) was constructed in ras2 by site-directed mutagenesis. Inducible constructs of ras2 and ras2Val14 we...

journal_title：Genes & development

authors： Bishop JG 3rd,Corces VG

更新日期：1988-05-01 00:00:00

abstract：:The LIM motif defines a double zinc finger structure found in proteins involved in cell fate determination and growth control. LIM proteins, which include LIM homeo domain, LIM kinase, focal adhesion, and LIM-only proteins, usually contain two or more LIM motifs clustered at their amino- or carboxy-terminal end. At pr...

journal_title：Genes & development

authors： Arber S,Caroni P

更新日期：1996-02-01 00:00:00

abstract：:Here we demonstrate that RNF4, a highly conserved small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, plays a critical role in the response of mammalian cells to DNA damage. Human cells in which RNF4 expression was ablated by siRNA or chicken DT40 cells with a homozygous deletion of the RNF4 gene displa...

journal_title：Genes & development

authors： Yin Y,Seifert A,Chua JS,Maure JF,Golebiowski F,Hay RT

更新日期：2012-06-01 00:00:00

abstract：:DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in...

journal_title：Genes & development

authors： Tovy A,Spiro A,McCarthy R,Shipony Z,Aylon Y,Allton K,Ainbinder E,Furth N,Tanay A,Barton M,Oren M

更新日期：2017-05-15 00:00:00

abstract：:The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crystal structure of the DR6...

journal_title：Genes & development

authors： Xu K,Olsen O,Tzvetkova-Robev D,Tessier-Lavigne M,Nikolov DB

更新日期：2015-04-15 00:00:00

abstract：:Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence to show if or how the p53 pathway functions during organogenesis. Here we present evidence to show that the zebrafish d...

journal_title：Genes & development

authors： Chen J,Ruan H,Ng SM,Gao C,Soo HM,Wu W,Zhang Z,Wen Z,Lane DP,Peng J

更新日期：2005-12-01 00:00:00

abstract：:A novel system to study early hematopoietic development is described. This report documents the in vitro capacity of murine embryonic stem (ES) cells to differentiate into hematopoietic precursors of most, if not all, of the colony-forming cells found in normal bone marrow. This system is used to correlate the genetic...

journal_title：Genes & development

authors： Schmitt RM,Bruyns E,Snodgrass HR

更新日期：1991-05-01 00:00:00

abstract：:The Ultrabithorax (Ubx) gene of Drosophila melanogaster encodes a family of UBX proteins that are thought to specify the developmental fates of segments in the posterior thorax and anterior abdomen by controlling the expression of a set of target genes. UBX proteins bind DNA in vitro, and they activate or repress diff...

journal_title：Genes & development

authors： Johnson FB,Krasnow MA

更新日期：1990-06-01 00:00:00

abstract：:TFIID is a multisubunit protein containing the TATA box-binding polypeptide (TBP) and associated factors (TFIID-TAFs) required for activated transcription by RNA polymerase II. TBPs from different eukaryotes contain a highly conserved carboxy-terminal domain and very divergent amino-terminal domains. Earlier studies p...

journal_title：Genes & development

authors： Zhou Q,Boyer TG,Berk AJ

更新日期：1993-02-01 00:00:00

abstract：:The balance between proliferation and differentiation of muscle stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle growth and repair. We demonstrate here that the transcriptional regulator Hes1 controls the balance between proliferation and differentiation of activated musc...

journal_title：Genes & development

authors： Lahmann I,Bröhl D,Zyrianova T,Isomura A,Czajkowski MT,Kapoor V,Griger J,Ruffault PL,Mademtzoglou D,Zammit PS,Wunderlich T,Spuler S,Kühn R,Preibisch S,Wolf J,Kageyama R,Birchmeier C

更新日期：2019-05-01 00:00:00

abstract：:The embryonic lethal abnormal visual system (ELAV) is a gene-specific regulator of alternative pre-mRNA processing in neurons of Drosophila. Here we define a functional in vivo binding site for ELAV in neurons through the development of a reporter gene system in transgenic animals in combination with in vitro binding ...

journal_title：Genes & development

authors： Soller M,White K

更新日期：2003-10-15 00:00:00

abstract：:The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate the transcription of gene products that control intracellular cholesterol homeostasis through catabolism and transport. In this report, we...

journal_title：Genes & development

authors： Repa JJ,Liang G,Ou J,Bashmakov Y,Lobaccaro JM,Shimomura I,Shan B,Brown MS,Goldstein JL,Mangelsdorf DJ

更新日期：2000-11-15 00:00:00

abstract：:We have identified protein kinase C-zeta (PKC-zeta) as a novel suppressor of neoplastic transformation caused by the v-raf oncogene. PKC-zeta overexpression drastically retards proliferation, abolishes anchorage-independent growth, and reverts the morphological transformation of v-raf-transformed NIH-3T3 cells. The mo...

journal_title：Genes & development

authors： Kieser A,Seitz T,Adler HS,Coffer P,Kremmer E,Crespo P,Gutkind JS,Henderson DW,Mushinski JF,Kolch W,Mischak H

更新日期：1996-06-15 00:00:00

abstract：:The repression of the maternally inherited Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR). Here we document that point mutations of the nucleotides in physical contact with CTCF within the en...

journal_title：Genes & development

authors： Pant V,Mariano P,Kanduri C,Mattsson A,Lobanenkov V,Heuchel R,Ohlsson R

更新日期：2003-03-01 00:00:00

abstract：:Pax3 is a key transcription factor implicated in development and human disease. To dissect the role of Pax3 in myogenesis and establish whether it is a repressor or activator, we generated loss- and gain-of-function alleles by targeting an nLacZ reporter and a sequence encoding the oncogenic fusion protein PAX3-FKHR i...

journal_title：Genes & development

authors： Relaix F,Polimeni M,Rocancourt D,Ponzetto C,Schäfer BW,Buckingham M

更新日期：2003-12-01 00:00:00

abstract：:Serotonin is a bioamine regulating bone mass accrual differently depending on its site of synthesis. It decreases accrual when synthesized in the gut, and increases it when synthesized in the brain. The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteobla...

journal_title：Genes & development

authors： Oury F,Yadav VK,Wang Y,Zhou B,Liu XS,Guo XE,Tecott LH,Schutz G,Means AR,Karsenty G

更新日期：2010-10-15 00:00:00

abstract：:Noncoding RNA regulators have been implicated in almost all imaginable cellular processes. Here we review how regulatory small RNAs such as Spot42, SgrS, GlmY, and GlmZ and a cis-encoded ribozyme in glmS mRNA control sugar metabolism. Besides discussing the physiological implications, we show how the study of these mo...

journal_title：Genes & development

authors： Görke B,Vogel J

更新日期：2008-11-01 00:00:00

abstract：:In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...

journal_title：Genes & development

authors： Kim S,Meyer R,Chuong H,Dawson DS

更新日期：2013-10-01 00:00:00

abstract：:Although the transporter-like protein Patched (Ptc) is genetically implicated in reception of the extracellular Hedgehog (Hh) protein signal, a clear definition of the Hh receptor is complicated by the existence of additional Hh-binding proteins and, in Drosophila, by the lack of physical evidence for direct binding o...

journal_title：Genes & development

authors： Zheng X,Mann RK,Sever N,Beachy PA

更新日期：2010-01-01 00:00:00

abstract：:Different RNA species are exported from the nucleus by distinct mechanisms. Among the different RNAs, mRNAs and major spliceosomal U snRNAs share several structural similarities, yet they are exported by distinct factors. We previously showed that U1 snRNAs behaved like an mRNA in nuclear export if various approximate...

journal_title：Genes & development

authors： Masuyama K,Taniguchi I,Kataoka N,Ohno M

更新日期：2004-09-01 00:00:00

abstract：:Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

journal_title：Genes & development

authors： Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

更新日期：2016-08-01 00:00:00

abstract：:The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β cells produce and secrete insulin in response to physiological cues like glucose, and these hallmark functions impro...

journal_title：Genes & development

authors： Bevacqua RJ,Lam JY,Peiris H,Whitener RL,Kim S,Gu X,Friedlander MSH,Kim SK

更新日期：2021-01-14 00:00:00

abstract：:While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of mi...

journal_title：Genes & development

authors： Elbarbary RA,Miyoshi K,Hedaya O,Myers JR,Maquat LE

更新日期：2017-07-15 00:00:00

abstract：:Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. In this issue of Genes & Development, Tovy and colleagues (pp. 959-972) report that, in naïve mo...

journal_title：Genes & development

authors： Laptenko O,Prives C

更新日期：2017-05-15 00:00:00

abstract：:The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair f...

journal_title：Genes & development

authors： Coulombe PA,Caterina MJ

更新日期：2013-06-15 00:00:00